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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.

Title: Postdoc NIH

Description:
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT, BETHESDA, MD AND SURROUNDING AREA

Position Description:
The research group of Dr. Anirban Banerjee at the National Institutes of Health (NIH) is seeking candidates for postdoctoral fellows . The broad interests of the lab are in membrane protein structure and function. We combine structural techniques such as macromolecular crystallography and cryo EM with biophysical and biochemical methods such as reconstitution based assays, high resolution light microscopy and small molecule screening to investigate the structural bases of the mechanisms of a number of membrane proteins.

The lab has state-of-the-art equipment and facilities. We have dedicated periodic access to the 22-ID beamline at the APS, for crystallographers at the NIH, as well as access to 23-ID and 24-ID beam lines at the APS. Our laboratory is part of the Cell Biology and Neurobiology Branch in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). We also have an affiliation to the National Institute of Neurological Disorders and Stroke (NINDS).

Qualifications:
The candidates should hold a Ph. D. degree, be author of at least one first author publication and have a strong background in biochemistry or structural biology. Experience with basic molecular biology, protein expression, purification and biochemical characterization are required. Prior experience in membrane protein biochemistry or mammalian expression system for protein purification will be added advantages.

It is absolutely essential the candidate is motivated and prepared to put in the best efforts for fruition of the project goals. We are a small, friendly lab and ability to work as part of a cohesive group is important.

To Apply:
Interested candidates can send an e-mail to anirban.banerjee@nih.gov with a CV and a summary of previous research experience and future interests.
The NIH is dedicated to building a diverse community in its training and employment programs.


[Post Date: February 15, 2019]

Title: Scientist Rottapharm Biotech Srl, Trieste, Italy

Description:
Rottapharm Biotech Srl is looking for a Protein Scientist to join the Biotherapeutics Discovery group.

The successful candidate, as part of a small team of interdisciplinary scientists, will play an integral role generating therapeutic candidates from the company discovery programs and demonstrate a good understanding of technologies required for developing proprietary biotherapeutics.

The application should be addressed to:
Dr. Michela Visintin (enclosing up-to-date curriculum vitae) Area Science Park, SS.14 km 163, Ed.Q1, 34149 Trieste- ITALY
E-mail: michela.visintin@rottapharmbiotech.com

POST TITLE: Scientist in Protein Biochemistry
JOB LOCATION: Area Science Park, ss.14 km 163, Ed.Q1, Basovizza- TRIESTE, Italy
DATE POSTED: 01/02/2019
UNPOSTING DATE: ongoing
JOB LEVEL: experienced
JOB TIPE: contract
Position Overview:
Rottapharm Biotech Srl is looking for a Protein Scientist to join the Biotherapeutics Discovery group. The successful candidate, as part of a small team of interdisciplinary scientists, will play an integral role generating therapeutic candidates from the company discovery programs and demonstrate a good understanding of technologies required for developing proprietary biotherapeutics.
We are looking for candidates who are fully independent and competent in the following skill sets:
• Molecular Biology (DNA manipulation techniques and use of VNTI and/or other DNA analysis software).
• Protein Expression in E. Coli and Mammalian cell systems.
• Protein Purification (Affinity, Ion Exchange, Hydrophobic Interaction Chromatography, Size Exclusion Chromatography, Analytical SEC, UV-Vis spectroscopy, protein refolding techniques and extensive working knowledge of AKTA purification platforms and associated software).
• Protein Analysis (SDS-PAGE, IEF, FPLC, HPLC, IP, DSF, ELISA, Western blotting).
• Molecular Modeling and Structure-based Analysis of proteins. Application of computational strategies to guide the design of biotherapeutics with improved biological properties and developability characteristics. o Collaborate with protein engineers and other scientists to support structure- and property-based design of therapeutic proteins and antibodies.
o Apply computational tools for predicting liabilities and biophysical properties that impact in vivo pharmacokinetics and manufacturability.
o Apply sequence analysis, structure modeling, and molecular dynamics approaches to analyse and predict biophysical properties and other structure-property relationships.


Responsibilities
• You will lead a small group of protein scientists
• You will be responsible for expressing and purifying high-quality recombinant protein reagents to support Rottapharm Biotech’s drug discovery platforms for a variety of therapeutic projects.
• You will use your excellent practical skills, communication and team working abilities to drive innovative projects forward from the laboratory.
• You will keep up to date with literature and public databases (PDB, NCBI) and demonstrate scientific knowledge in the design and execution of value-adding experiments.
• You will be responsible for clearly presenting work and engaging in discussion in a variety of cross-functional and external collaborator meetings.
• You will also be responsible for ensuring that lab processes run smoothly within the group.

Basic Qualifications
• Doctorate degree with more than 4 years of post-doctoral scientific experience.
• Proficiency with Microsoft Office applications and instrument specific software.
• Must possess a strong work ethic, attention to detail, and excellent problem-solving skills.
• Excellent communication skills (Italian and English).
• Strong project leadership and resource management skills.
• Demonstrated experience in the evaluation of engineered proteins through biochemical and biophysical analysis.
• Proficient in Structure-based analysis of proteins.
• Knowledge of state-of-the-art protein biochemistry techniques.
• A highly motivated individual with a proven ability to deliver to tight timelines.
• A team player, with good organisational, communication, record keeping and inter-personal skills.
• Possess an inquisitive and inventive nature and a passion for discovering innovative new drugs for patients suffering with serious disease.

Preferred Qualifications
• Ph.D. degree with a focus on Protein Biochemistry or related area.
• Ph.D. and postdoc from a leading institution or biotechnology company.
• Experience in working with monoclonal antibody and recombinant proteins is preferred, with demonstrated expertise in upstream and/or downstream process development and analytical expertise is a bonus.
• Proven track record of academic accomplishments (i.e., peer-reviewed publications and/or patents).
• Hands on experience with Biacore/Octet or microITC instruments is highly desired.


[Post Date: February 14, 2019]

Title: Postdoc MPX Lab ITQB NOVA
Website: http://mx.itqb.unl.pt/

Description:
We have a job opening for a PhD researcher (contract up to 3 years) to work in a multidisciplinary project at the interface of Structural Biology, Biochemistry and Microbiology.

Very briefly, the project aims at the structural and functional characterization of mycobacterial membrane enzymes involved in the biosynthesis of cell wall components using a combined approach of X-ray Crystallography and Cryo-Electron Microscopy. It will also involve activity assays to provide insights into the reaction mechanism of these glycosyltransferases, synthesis of chemical compounds that may inhibit these enzymes, virtual screens, docking and molecular simulations.

The project is developed in close collaboration with Filippo Mancia, Columbia University (New York, USA).

To learn more about this project send an email to Margarida Archer (archer@itqb.unl.pt).


[Post Date: February 14, 2019]

Title: Postdoc Brown University, USA
Website: https://www.deaconesculab.com/

Description:
The Deaconescu Lab at Brown University has one opening for a postdoctoral researcher. The laboratory's interests lie primarily in stress responses, with particular emphasis on responses to DNA damage and the mechanochemistry of DNA-based motors. We utilize a combination of biochemical, biophysical and structural techniques. (e.g. X-ray crystallography, small-angle X-ray scattering, transmission electron microscopy). For examples of work, please see Vemu et al. Science (2018), Le TT et al. Cell (2018), Deaconescu et al. Photochemistry and Photobiology (2017), Kutter et al. JMB (2016), Szyk et al, Cell (2014), Deaconescu et al., PNAS (2012), Szyk et al., NSMB (2012) and Deaconescu et al., TIBS (2013).

A successful candidate should have an established track-record of publications in peer-reviewed journals; solid experience with protein biochemistry (including their purification from E.coli/yeast expression, functional characterization and assay development). Prior knowledge of crystallography and/or single-particle electron microscopy is highly desirable. Crystals/data at various stages of the structure determination process are available for immediate work. Must be highly motivated and work independently as well as in a team. Excellent spoken and written English are required. New Ph.D. graduates are encouraged to apply.

Interested candidates should send a CV, one page research experience summary and contact information for three references to alexandra_deaconescu@brown.edu. Salary and starting date are negotiable. Please write Postdoctoral Candidate in the e-mail subject header. Brown University, an Ivy League school, is located less than one hour away by train from Boston.


[Post Date: February 13, 2019]

Title: Postdoc Texas Tech University

Description:
A staff position is open for a protein crystallographer at a postdoctoral research associate level in Guan Lab at Department of Cell Physiology and Molecular Biophysics of Texas Tech University Health Sciences Center, TX. The Lab is working on multiple projects on bacterial/human nutrient transporters using X-ray crystallography, thermodynamics, EPR, and other biochemical/biophysical techniques.

The laboratory seeks a motivated individual with a strong knowledge and expertise in protein structure determination by X-ray crystallography. Salary is competitive based on experience. For more details see:

http://www.ttuhsc.edu/medicine/cell-physiology-molecular-biophysics/faculty/guan

https://www.ttuhsc.edu/centers-institutes/membrane-protein-research

Interested applicants should submit their CV and contact information for three references along with a cover letter through our website (http://www.texastech.edu/careers/staff-positions.php) with the requisition ID of 14651BR. TTUHSC is an EEO/AA employer.


[Post Date: February 12, 2019]

Title: Postdoc Cornell University

Description:
Postdoctoral Associate Position at Cornell University in Biomolecular Small-Angle X-ray Scattering and X-ray Crystallography

One or two postdoctoral positions are available in small-angle x-ray scattering and x-ray crystallography of biomolecules in the group of Prof. Robert Thorne in the Physics Department at Cornell University (www.lassp.cornell.edu/Thorne/). The focus of the work will be on developing and applying new experimental, analysis, and modeling methods for high-throughput cryogenic temperature SAXS and for high-throughput variable temperature crystallography. The work may involve protein expression and purification, X-ray data collection (at CHESS, APS, or NSLS), laboratory-based experiments, analysis method development, and modeling, as well as CAD design, microfabrication, and hardware fabrication and assembly, depending upon the skills and interests of the successful applicant(s) Applicants should have a Ph.D. in Biophysics, Physics, Chemistry, Biochemistry or related fields. Relevant areas of experience include bioSAXS data collection, analysis and modeling; X-ray crystallography and crystallographic refinement; protein expression, purification, and crystallization; and laboratory apparatus design, machining, and assembly; and microfabrication.
The initial Postdoctoral Associate appointment will be for one year, with the expectation for renewal for at least one additional year. Start dates are flexible, and can be as early as March 2019.

Application material should be submitted to ret6@cornell.edu. Complete applications will include a brief cover letter, a CV, a detailed summary of research experience and interests, and three letters of recommendation. Recommendation letters, if not initially provided, will be requested after application screening.

Diversity and Inclusion are a part of Cornell University’s heritage. The College of Arts and Sciences at Cornell embrace diversity and seek candidates who will create a climate that attracts students and faculty of all races, nationalities, and genders. We strongly encourage women and underrepresented minorities to apply. Cornell University is a recognized EEO/AA employer and educator, valuing AA/EEO, Protected Veterans, and Individuals with Disabilities.


[Post Date: February 10, 2019]

Title: Technical Staff Position PPSCF EPFL Switzerland
Website: https://recruiting.epfl.ch/Vacancies/833/Description/2

Description:
The Protein Production and Structure Core Facility has a new open position for a technical staff (CDI, 80-100%, location EPFL Lausanne Switzerland). The main duties will be to advise, assist and follow-up X-ray crystallisation projects for various users; as well as to produce and purify recombinant proteins from a variety of hosts. Apply at the above link.



[Post Date: February 06, 2019]

Title: Postdoc University of Kent

Description:
Come and work on talin mechanobiology!

Exciting new project in collaboration between the Goult Lab (University of Kent) and the Brown lab (University of Cambridge). We have 2 BBSRC funded postdoc positions looking at harnessing protein unfolding and aggregation in mechanotransduction .

One position is for a structural biologist/biochemist with expertise in NMR or X-Ray at the University of Kent.

https://www.jobs.ac.uk/job/BPR871/postdoctoral-research-associate

and a second position at the University of Cambridge with Prof Nick Brown using drosophila genetics

https://www.jobs.ac.uk/job/BPS697/research-assistant-associate-harnessing-protein-unfolding-and-aggregation-in-mechanotransduction

For more information on talins role as a mechanosensitive signalling hub see our recent perspective article: http://jcb.rupress.org/content/217/11/3776/tab-article-info


[Post Date: February 05, 2019]

Title: Positions at ICR, London, UK
Website: https://www.icr.ac.uk/

Description:
The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. We provided the first convincing evidence that DNA damage is the basic cause of cancer, laying the foundation for the now universally accepted idea that cancer is a genetic disease. Today, The Institute of Cancer Research (ICR) leads the world at isolating cancer-related genes and discovering new targeted drugs for personalised cancer treatment.

The Cancer Research UK Cancer Therapeutics Unit (CTU), within the Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around 160 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. The CTU’s exciting goal is to discover high quality small molecule drug candidates and to progress these to clinical trial. All the scientific disciplines are in place to make this possible, including assay development and screening, medicinal chemistry, biology, structural biology, metabolism and clinical specialists.

Two postdoctoral positions in Structural Biology (ID 642) and a Higher Scientific Officer position in protein production, assay development and biophysics (ID 645) are available in Dr Rob van Montfort’s Hit Discovery and Structural Design (HDSD) Team within the CTU.

The postdoctoral researchers in structural biology will be involved in X-ray crystallography, fragment-based screening and structure-based drug design and will be responsible for protein expression, purification, crystallisation, structure determination and structural analysis of protein-ligand complexes from one of the CTU’s drug discovery programmes. The successful candidates will also be part of the Division of Structural Biology, in which the crystallographers in Dr van Montfort’s team are embedded, and will have access to state of the art crystallisation facilities, an in-house X-ray source and excellent access to synchrotrons. The successful candidate will interact closely with the biology, computational chemistry and medicinal chemistry teams at the CTU, and will therefore be expected to work across the two sites in Chelsea, London and Sutton, Surrey. Applicants must have a PhD in a biological or physical science, and experience in macromolecular crystallography (to include protein biochemistry, protein crystallisation, & protein crystallography). Experience in molecular biology, protein expression in insect cells, structure-based drug design, and/or biophysics will be an advantage. The starting salary for the positions will be in the range £31,023 to £39,473 p.a. inclusive (based on previous post-doctoral experience). One position is funded for one year and one is funded for two years. Applicants will automatically be considered for both positions. Informal enquiries can be made via email to rob.vanmontfort@icr.ac.uk or yann-vai.lebihan@icr.ac.uk.

The higher scientific Officer protein production, assay development and biophysics will be involved in establishing the expression, purification and characterisation of one of our early stage drug targets, using contemporary expression systems and purification methods available within the HDSD team. The postholder will be based in Sutton. In addition, the post-holder is expected to characterise ligand and inhibitor binding to the recombinant proteins using biochemical assays and biophysical methods such as Thermal-shift assays, surface plasmon resonance (SPR), isothermal titration calorimetry (ITC) and ligand-based NMR methods. The successful candidate will be an integral member of a multidisciplinary project team and will interact closely with the biologists, computational chemists, medicinal chemists and structural biologists. Applicants must have a BSc in a biochemistry or related biological subject and in depth technical laboratory experience in protein expression and purification methodologies. Expertise in insect cell expression, assay development and/or knowledge of protein NMR methods would be advantageous. The starting salary for the position will be in the range of £33,285 to £37,359 p.a. inclusive (based on previous experience) and the post is offered on a fixed term contract of 1 year. Informal enquiries to rosemary.burke@icr.ac.uk or rob.vanmontfort@icr.ac.uk

Please DO NOT send your application to Dr van Montfort, Dr Burke or Dr Le Bihan. Applications will only be considered if made via the e-recruitment system on our website www.icr.ac.uk.


[Post Date: February 04, 2019]

Title: Assistant Professor University of Saskatchewan
Website: https://medicine.usask.ca/profiles/biochemistry-microbiology-immunology/index.php

Description:
Assistant Professor
Tenure-Track Positions
Department of Biochemistry, Microbiology and Immunology
College of Medicine, University of Saskatchewan

The Department of Biochemistry, Microbiology and Immunology (BMI) at the University of Saskatchewan invites applications for two tenure-track positions at the level of Assistant Professor. We are searching for individuals with exceptional promise to develop a vibrant, externally funded research program in any area of biochemistry, microbiology or immunology. The successful candidate will also show a strong commitment to undergraduate and graduate teaching.

The department has several areas of research strength encompassing structural, genetic, cellular and molecular biological and biochemical investigator-led programs focused on viral and bacterial pathogenesis, cancer biology, immunology and various aspects of metabolism, offering many opportunities for interdisciplinary collaboration. Specific research areas of BMI faculty can be viewed here: (https://medicine.usask.ca/profiles/biochemistry-microbiology-immunology/index.php). The department benefits from having the Canadian Light Source situated on our campus, and the department has strong affiliations with the Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac) and the Saskatchewan Cancer Agency.

The University of Saskatchewan’s main campus is situated on Treaty 6 Territory and the Homeland of the Métis. The University of Saskatchewan is located in Saskatoon, SK, a city with a diverse and thriving economic base, a vibrant arts community and a full range of leisure opportunities. The University has a reputation for excellence in teaching, research and scholarly activities and offers a full range of undergraduate, graduate, and professional programs to a student population of over 24,000.

Qualifications
Applicants must have a PhD degree and post-doctoral experience in a biomedical discipline and a demonstrated ability to conduct original, innovative research. The ideal candidate will have excellent interpersonal and communication skills, and show an interest in fostering collaborations with faculty members in the department and elsewhere on campus.

The salary band for Assistant Professor is $93,293 to $112,109. This position includes a comprehensive benefits package which includes a dental, health and extended vision care plan, pension plan, life insurance (compulsory and voluntary), academic long term disability, sick leave, travel insurance, death benefits, an employee assistance program, a professional expense allowance, and a flexible health and wellness spending program.

The University of Saskatchewan is committed to diversity, inclusion, and equity in the workplace, and encourages applications from members of the four designated equity groups (women, members of a visible minority, Indigenous persons, and persons with disabilities). Applicants are also encouraged to self-identify as a member of one of the equity groups listed above in their cover letter.

Interested candidates must submit via email a cover letter, a detailed curriculum vitae, a brief statement of research interests and 5-year research plan (max. 3 pages), a teaching statement (1 page), and contact information for three references. In the cover letter, applicants should clearly state their citizenship or immigration status. The complete application package should be sent to:
Dr. Bill Roesler
Professor and Head
Department of Biochemistry, Microbiology, and Immunology
107 Wiggins Road, Rm 2D01
Saskatoon, SK Canada S7N 5E5
Telephone: (306) 966-4375
Email: Shannon.degagne@usask.ca

Review of applications will begin February 2019; however, applications will be accepted and evaluated until the position is filled. The anticipated start date is July 1, 2019.

The University of Saskatchewan is strongly committed to a diverse and inclusive workplace that empowers all employees to reach their full potential. All members of the university community share a responsibility for developing and maintaining an environment in which differences are valued and inclusiveness is practiced. The university welcomes applications from those who will contribute to the diversity of our community. All qualified candidates are encouraged to apply, but Canadian citizens and permanent residents will be given priority.


[Post Date: February 01, 2019]

Title: Postdoc Yale School of Medicine

Description:
The Lee Lab in the Department of Pharmacology, at the Yale School of Medicine, has an immediate opening for a highly motivated Postdoctoral Associate to investigate the molecular mechanism of endocrine fibroblast growth factor (FGF) signaling. Endocrine FGFs, which include, FGF15/19, FGF21, and FGF23, activate signaling via FGF receptors and require binding to the Klotho family of surface receptors; FGF23 signaling requires alpha-Klotho, while FGF15/19 and FGF21 signaling requires beta-Klotho. The research in our laboratory is focused on the structural elucidation, biophysical, and biochemical analyses of complexes involved in endocrine FGF signaling.

Applicants should have a PhD in biochemistry, biophysics, or a related field and should have extensive experience in recombinant protein production (E.coli and mammalian cells) and structural biology techniques (X-ray crystallography or cryo-EM), as well as excellent written and oral communication skills. Experience with mammalian cell culture and quantitative biophysical analyses are also desirable.

Interested candidates should send a current CV, a statement of research interests, and the names and contact information of three references to Sangwon Lee (s.lee@yale.edu).

Yale University is an Affirmative Action/Equal Opportunity Employer and welcomes applications from women, members of minority groups, persons with disabilities and protected veterans.


[Post Date: January 29, 2019]

Title: Postdoc Fudan University of Shanghai

Description:
The Multiscale Research Institute for Complex Systems (MRICS) at Fudan University is located at the Zhangjiang Campus of Fudan University and is supported by the Shanghai High-peak Program. MRICS is strongly committed to the development of novel and effective multi-scale imaging technology that spans microscopic molecular structures all the way to macroscopic medical imaging, with the aim to provide unprecedented spatial and temporal insights into the structures and functions of living beings at all levels (molecules, cells, tissues, organs and even whole organisms). MRICS is equipped with a state-of-the-art cryo-EM facility that includes FEI Titan Krios equipped with Volta phase plate, Glacios, Talos and Aquilos. It is also located next to Shanghai Synchrotron Radiation Facility for X-ray crystallography.

Our team includes Nobel laureate and international leading interdisciplinary experts.
We are now open to recruit a number of postdoctoral fellows with trainings in various scientific fields. These include but are not limited to:

1.Structural biology (X-ray crystallography and cryo-electron microscopy
including single-particle and tomography);

2.Biochemistry or protein chemistry (no structural biology background is
required);

3.Genetics, epigenetics or cell biology (experience in cell or tissue
imaging is preferred);

4.Computational biology (the development of large-scale molecular dynamics
simulation algorithms, algorithmic development related to electron microscopy
imaging techniques, and the application of artificial intelligence in biology.
We particularly welcome applicants with Ph.D. degree in theoretical physics,
computational physics or condensed matter physics);

5.Development of experimental animal disease models (experience in experimental animal research is preferred).

Other criteria:
1) Recent Ph.D. graduates
(within three years of graduation) from a well-known university or research institute anywhere in the world;

2) Fluent in English;

3) Published high-level research articles in the past three years.

Compensation:
1) We offer internationally competitive annual salary, the level will be determined according to the applicant's experience and qualification;

2) We will assist in applying for low-rent housing in Shanghai and provide certain housing subsidies;

3) We have ample opportunities to collaborate with renown laboratories worldwide;

4) We provide support for applying for funding opportunities whenever applicable.

For interested applicants,please submit postdoctoral application packages including resumes, concise research interest statements, representative publications, phone numbers and email addresses of three academic referees to: Miss Lingyue Guo ( Email: lyguo@fudan.edu.cn).

We look forward to your joining of our first-class team!


[Post Date: January 23, 2019]

Title: Postdoc NREL
Website: https://nrel.wd5.myworkdayjobs.com/en-US/NREL/job/Golden-CO/Postdoctoral-Researcher---Biophysics-and-Structural-Biology_R4213

Description:
Postdoctoral Researcher - Biophysics and Structural Biology

Job Summary
The National Renewable Energy Laboratory (NREL) is a leader in the U.S. Department of Energy’s effort to secure an energy future that is both environmentally and economically sustainable. With locations in Golden, Boulder and Washington D.C., NREL is the primary laboratory for research, development and deployment of renewable energy technologies in the United States. The NREL mission is to develop renewable energy and energy efficient technologies and practices, advance related science and engineering, and transfer knowledge and innovation to address the nation’s energy and environmental goals.

The Biosciences Center at NREL has an opening for a full time postdoctoral researcher in Biophysics and Structural Biology to study metabolic and biomass degrading enzymes and macromolecular complexes involved in biomass deconstruction as well as the production of biochemicals/biopolymers. The project will involve the determination of the structures and dynamics of enzymes and enzyme complexes using cryo-EM, neutron/X-ray scattering, or NMR potentially in combination with X-ray crystallography and molecular modeling. These structures will be used in subsequent molecular modeling studies and the successful candidate will work very closely with a team of computational scientists.

Additionally, the successful candidate will be tasked with building interfaces to better analyze experimental data from these techniques (especially for cryo-EM) using classification methodologies, and incorporating results from molecular models for single particle reconstruction of more complex and heterogeneous enzyme preparations. The successful candidate will be part of a multidisciplinary team of researchers working on several projects related to biomass deconstruction and the production of biochemicals/biopolymers.

Desired Qualifications:
• Ph.D. in Biophysics, Structural Biology or a closely related field
• Demonstrating experience in the structural determination of macromolecular assemblies using cryo-electron microscopy
• Additional experience with X-ray/neutron scattering or single-molecule biophysics is required
• Demonstrated experience in the characterization of protein-protein complexes using a variety of biophysical methods (ITC, AUC, DLS, SPR, or NMR)
• Proficiency in Linux and familiar with at least one scripting language (such as Perl or Python)
• Strong written and oral communication skills, as well as the ability to work independently and pre-pare scientific manuscripts are required
• Job duties include disseminate knowledge through publications in technical journals and presentations at conferences, symposia, and review meetings. The ideal candidate would also provide reports on technical work and input to technical publications and presentations

Required Education, Experience, and Skills
Must be a recent PhD graduate within the last three years.


[Post Date: January 22, 2019]

Title: Postdoc INRA - Université Paris-Saclay

Description:
Post-doctoral position in Structural Biology - INRA - Université Paris-Saclay
A post-doctoral position funded by an ERC project is available at the ChemSyBio laboratory near Paris (INRA, Université Paris-Saclay, Micalis, Jouy-en-Josas). We are seeking for a highly motivated post-doctoral fellow with a proven experience in structural biology.

The candidate should have a PhD in protein Biochemistry and/or Structural biology. Experience in protein purification and molecular biology is expected. Skills in various protein expression systems and physico-chemical techniques would be an asset.

The successful candidates will join the team headed by Dr Olivier Berteau on a highly competitive research topic related to the mechanistic investigation of a novel family of enzymes. The project aims at studying structural aspects of metallo-enzymes involved in key biological transformations in bacteria.

Recent publications from our team include:
• Parent A. et al. 2018 J Am Chem Soc. ; 140(7):2469-2477.
• Benjdia A et al. 2017 Nature Chemistry ; 9(7):698-707
• Parent A. et al. 2016 J Am Chem Soc.; 138(48):15515-15518
• Benjdia A. et al.2016 Chem Commun.; 52(37):6249-52
• Benjdia A. et al. 2015 Nat Commun; 6:8377.

Access to state-of-the-art research facilities will be provided. The position is offered for a renewable one year period. The salary will be commensurate with experience.

Applications (including CV, description of your research activity indicating your relevant skills and a list of three references) should be sent to Dr Alhosna Benjdia (alhosna.benjdia@inra.fr) and Dr Olivier Berteau (Olivier.Berteau@inra.fr).


[Post Date: January 22, 2019]

Title: Postdoc IINS, CNRS, University of Bordeaux, France
Website: http://www.iins.u-bordeaux.fr/JOB-OPENINGS-302

Description:
Postdoctoral position available in a newly established research team at the Interdisciplinary Institute for NeuroScience (IINS), CNRS / University of Bordeaux, France, to study the structure and function of novel neuronal ligand-receptor complexes. The position is fully funded for up to 3 years. The candidate must hold a PhD degree, have less than two years of post-doctoral experience, and have a solid background in molecular biology, biochemistry and/or structural biology.

Further information and details can be found at the link.

Interested candidates may contact me directly jonathan.elegheert@u-bordeaux.fr for all inquiries; please include a CV describing your research activities and relevant skills, as well as contact details for 2-3 referees.


[Post Date: January 22, 2019]

Title: Postdoc UCSF
Website: http://www.msg.ucsf.edu/stroud/index.htm

Description:
A post-doctoral position is available in the laboratory of Prof. Robert Stroud at the mission bay campus of the University of California San Francisco (UCSF). (http://www.msg.ucsf.edu/stroud/index.htm). Research is focused on the mechanisms of transmembrane processes, and particularly in this position in HIV accessory proteins and regulatory complexes (https://harc.ucsf.edu/), and in mycobacterium Tuberculosis and the structures of molecular complexes using Cryo Electron Microscopy, X-ray diffraction as inroads to defining function, assembly of complexes. This also involves expression and purification of membrane proteins often in complex with other proteins, use of detergents, and nanodiscs. Experience in any of these areas is an advantage. First rate facilities are available in a highly cooperative environment. NRSA postdoctoral stipend levels+benefits. If interested please send a brief cover letter, CV and contact information for three persons who might provide references to stroud@msg.ucsf.edu




[Post Date: January 22, 2019]

Title: Postdoc Research Associate
Website: https://www.imperial.ac.uk/jobs/description/MED00834/research-associate/

Description:
Reference: MED00834

Job Title: Research Associate

Section/Division/Department: Structural Biology / Experimental Medicine / Medicine

Salary: £37,904 – £45,547 per annum

Campus: South Kensington
We wish to recruit two Research Associates to work in the research group of Professor Dale Wigley (http://www.imperial.ac.uk/people/d.wigley), in the Section of Structural Biology, Department of Medicine, at Imperial College London’s South Kensington Campus. The successful candidates will join a multi-disciplinary team of international researchers investigating the structures and mechanisms of chromatin modifying complexes in human DNA damage repair and cancer. We combine structural biology techniques with biochemistry to understand molecular mechanisms for DNA repair that prevent cancer in humans. The successful candidates will have proven expertise in either or both of these areas.
You must hold a PhD, or equivalent, in biochemistry, enzymology or structural biology and have a demonstrated track record in conducting high quality original research. Knowledge at postgraduate level in structural biology (crystallography or electron microscopy) and/or biochemistry is essential and experience in expression/purification of multi-protein complexes in insect or human cells is desirable.

This is a full-time, fixed-term post for five years. Appointments will be made at the start of the salary scale.

To apply, please visit https://www.imperial.ac.uk/jobs/description/MED00834/research-associate/

Closing date: 24th February 2019

Imperial Expectations guide the behaviour of all our staff.

Should you have any queries please contact:
Professor Dale Wigley – d.wigley@imperial.ac.uk

Should you have any queries regarding the application process, please contact:
hr-dom@imperial.ac.uk

Committed to equality and valuing diversity, we are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and are working in partnership with GIRES to promote respect for trans people.

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/


[Post Date: January 22, 2019]

Title: Postdoc Masaryk University

Description:
We are seeking a highly motivated scientist for EU-funded postdoctoral position in protein structural biology for an experimental team at Loschmidt Laboratories, Masaryk University, Brno, Czech Republic (https://loschmidt.chemi.muni.cz/peg/).

JOB DESCRIPTION:
Perform protein expression, purification and biophysical characterization.
Design and perform protein crystallization experiments.
Collect X-ray diffraction data and determine protein-ligand complex structures.
Adopt emerging structural techniques (nanocrystallography and cryo-EM).
Work in an inspiring and highly collaborative environment.
Opportunities for further training, competitive salary, and benefits package.

PROFILE OF CANDIDATE:
Ph.D. in structural biology, molecular biology, biochemistry or biophysics.
Experience with protein expression and purification.
Previous experience with protein structural techniques (crystallography or cryo-EM).
Experience with biophysical and biochemical protein characterization.
Willingness to learn new techniques (time-resolved crystallography or cryo-EM).
Ability to develop new concepts, goal-oriented and problem-solving skills.
Good proficiency in English.

APPLICATIONS:
Curriculum Vitae and motivation letter
Two letters of recommendation
Send your application to Jitka Sedlackova at jitkasedlackova@mail.muni.cz

SELECTED PAPERS:
J. Am. Chem. Soc. 140: 17999, 2018 ACS Catalysis 8: 9420, 2018 J. Am. Chem. Soc. 137: 4988, 2015 ACS Catalysis 6: 7597, 2016
Chem. Rev. 113: 5871, 2013 Curr. Opin. Chem. Biol. 19: 8, 2014
Angewandte Chemie 52: 1959, 2013 Nature Chem. Biol. 10: 428, 2014


[Post Date: January 22, 2019]

Title: NCI Chief of Structural Biology

Description:
The NCI intramural is currently recruiting for a Chief of Structural Biology in the NCI Center for Cancer Research (CCR). This is a newly created position that reflects NCI’s strong and long-term commitment and support of structural biology and molecular biophysics. The incoming Chief will be the intellectual and administrative leader of the NCI intramural structural biology/biophysics research program and the NCI structural biology/biophysics community. Located on the NCI campus in Frederick, MD, the new Chief of Structural Biology will ultimately oversee a department of about 10 research groups, comprising around 100 scientists and trainees, currently housed in the Structural Biophysics Laboratory and the Macromolecular Crystallography Laboratory. In this new role, the incumbent will have the opportunity to determine the direction of the NCI structural biology/biophysics research program through several new hires over the next few years.

The Chief’s research program will be fully supported by generous, stable funds providing unmatched intellectual freedom and encouraging innovative, creative research in the intramural program. The Chief will also have access to extensive structural biology/biophysics infrastructure in the NCI intramural program including a state of the art cryo-EM facility, NMR, X-ray, XFEL, SAXS and computational resources. In addition, the position offers unmatched opportunities for interaction and collaboration with a large number of world-class biomedical and clinical researchers in the NIH intramural program.

The successful candidate will have a strong track record in any field of structural biology or molecular biophysics, as well as a vision for the development of a multi-PI research program in structural biology/biophysics. Administrative experience is desirable.

Further information about the this position and instructions for applying can be found at https://irp-positions.nih.gov/apply/index.cgi?pid=2c58652186abe9c3 .


[Post Date: January 22, 2019]

Title: Postdoc CUHK(SZ)

Description:
Two to three postdoctoral positions are currently available in the laboratory of Dr. Goran Stjepanovic (https://www.stjepanoviclab.org/) at the School of Life and Health Sciences (LHS) and Kobilka Institute of Innovative Drug Discovery (KIIDD), the Chinese University of Hong Kong-Shenzhen CUHK(SZ).

Our research interests is to understand the structural and mechanistic basis of autophagosomal and autolysosomal membrane formation and dynamics using a combination of state-of-the-art structural and biochemical/biophysical techniques. The available subprojects are highly interdisciplinary and range from proteomics approaches to the study of macromolecular complexes using cryo-electron microscopy.

KIIDD is equipped with a state-of-the-art cryo-EM facility that includes two FEI Titan Krios equipped with K3 and Falcon III direct detector, Gatan Energy Filter and Volta Phase Plate as well as high performance computing resources.

The candidates with expertise in biochemistry, structural biology or a related discipline, who are interested in interdisciplinary research are encouraged to apply. Hands-on experience in protein expression and purification, as well as functional analysis using biochemical and biophysical techniques, are prerequisites. Experience in membrane protein biochemistry, fluorescence microscopy, mass spectrometry, and/or cryo-EM is an advantage. Good writing skills and fluency in English are required.

If you are interested in this position, please contact Dr. Stjepanovic directly by sending a cover letter describing your interests in our laboratory and projects as well as your CV and a list of two individuals as references to goranstjepanovic@cuhk.edu.cn


[Post Date: January 21, 2019]

Title: Postdoc University of Toronto

Description:
A postdoctoral position is immediately available in my lab at the Structural Genomics Consortium at the University of Toronto. My lab aims to characterize protein-protein, protein-DNA and protein-RNA complexes by X-ray crystallography in combination with other biochemical and biophysical techniques. More details about our research can be found at the http://www.sgc.utoronto.ca/Chromatin or https://www.thesgc.org/node/12166.

Applicants should have a Ph.D. in structural biology, biochemistry, or molecular/cell biology with 0-3 years postdoctoral research experience. Interested candidates are invited to send their CV with 3 references to Dr. Jinrong Min by email: jr.min@utoronto.ca.


[Post Date: January 21, 2019]

Title: Postdoc Center for Structural Biology, VIB
Website: https://vibvzw.jobsoid.com/j/16843/postdoctoral-researcher-in-structural-biology-for-the-study-of-redox-sensitive-proteins

Description:
Postdoctoral researcher in structural biology for the
study of redox sensitive proteins

Position: A postdoctoral research position is immediately available for structurefunction
studies of proteins involved in redox metabolite signaling. Successful
candidates will join the exciting research environment of the Messens VIBlaboratory
at the Center for Structural Biology in Brussels, Belgium. The
Messens laboratory is recognized as a world leader in the redox field, and the
lab provides an outstanding position in protein biochemistry and structural
biology, in a highly dynamic and team-oriented research group. In this cuttingedge
research environment, you will tackle essential biological problems in
metabolite signaling.

Mission of the lab: We decipher how cells sense redox metabolites and
transduce stimuli into downstream biological effects. Knowledge of the
mechanisms by which sensors and transducers function are invaluable in
understanding how redox homeostasis pathways can be engineered with the
ultimate goal of improving oxidative stress resistance in plants and to identify
therapeutic targets in diseases such as diabetes and cancer, which have been
associated with aberrant redox signaling.

Your role in the lab: You will be involved in a project that exploits prokaryotic
proteins for the de novo design of biosensors with a fluorescent read-out for
both in vitro studies and live imaging of cellular metabolic changes. Further,
your expertise will be needed for the structural and functional analysis of plant
H2O2-sensing proteins to explore how organelle communication functions at the
molecular level.

Requirements: Applicants should have obtained a PhD in the last 5 years
within the field of structural biology and should have hands-on expertise with
protein purification, protein crystallization, diffraction data collection at
synchrotron beamlines, and solving protein crystal structures. Fluency in
English is a must. Experience with biophysical techniques is a plus, but not
required.

Please include a cover letter discussing your interests in our laboratory and
projects as well as your CV and a list of 3 individuals as references when
applying to Jobsoid (https://vibvzw.jobsoid.com/j/16843/postdoctoralresearcher-
in-structural-biology-for-the-study-of-redox-sensitive-proteins).


[Post Date: January 18, 2019]

Title: Structural Biologist for Malaria
Website: https://www.wehi.edu.au/postdoctoral-fellow-tham-laboratory

Description:
An opportunity exists for a Postdoctoral Fellow to join the Infection and Immunity Division at the Walter and Eliza Hall Institute to study the molecular events that occur during malaria parasite entry into human red blood cells and to decipher the structure of invasion complexes.

This is a postdoctoral position for a researcher with structural biology experience. The position is available for 3 years in the first instance. Salary range ranging from AUD $86,472 - $92,817 and is dependent on qualifications and experience.

Application deadline is February 22nd 2019. To apply, please follow the link above. For additional questions, please contact A/Prof. Wai-Hong Tham at tham@wehi.edu.au. To learn more about our lab: https://www.wehi.edu.au/people/wai-hong-tham


[Post Date: January 18, 2019]

Title: Postdoc Umeå University
Website: https://barandunlab.org/

Description:
Postdoctoral position in structural biology to study infection related processes

Research group

Our research group is located at the University of Umeå and affiliated with the Molecular Infection Medicine Institute Sweden (MIMS) and Science for Life Laboratory (SciLifeLab). We are using a combination of in vivo assays, biochemistry and cryo-electron microscopy to study macromolecular complexes of specialized pathogenic organisms (prokaryotes and eukaryotes). We aim to provide a molecular basis of key mechanisms in the infection process and uncover unique structural determinants that could serve as novel targets for antibiotics.

Requirements

We are seeking an independent researcher with experience in genome manipulation using CRISPR/Cas9 who would like to apply state-of-the-art techniques in cryo-electron microscopy to study infection related processes in a pathogenic organism. The project involves establishing genomic manipulation tools, reconstitution of a unique infection mechanism in heterologous expression systems and structural studies using cryo-electron tomography and single particle analysis.

Highly motivated candidates who would like to work in a young and dynamic team are encouraged to apply. A background in molecular biology, genome manipulation (CRISPR/Cas9) and biochemistry is required and experience with C. elegans and structural biology a plus. Please contact me with a CV, short letter of motivation and contact information for at least 2 reference persons.

Contact information

Jonas Barandun
jonas.barandun@umu.se


[Post Date: January 15, 2019]
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