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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.

Title: Postdoc University of Alberta

Description:
A postdoctoral fellowship appointment is available in the Lemieux lab in the Department of Biochemistry, Faculty of Medicine and Dentistry at the University of Alberta. The successful applicant will conduct research on membrane embedded enzymes. This work will be conducted with a strong multidisciplinary team at the University of Alberta and abroad (our lab is part of an International Research Training Group with labs in Germany). This position is available January 2019. The Lemieux lab is part of the Membrane Protein Disease Research Group that, besides fostering a strong network of labs working on membrane proteins, provides professional development career skills classes.

· The candidate should have a Ph.D. in biochemistry, molecular biology, or similar field.
· Experience in protein purification, membrane protein purification, X-ray crystallography, and/or cryoEM is desired.
· Experience with mass spectrometry, microscale thermophoresis, SPR, and thermal shift assays would be an added benefit.

The successful candidate should be able to conduct research independently, analyze and interpret data, and write journal articles, as well as should be able to work in a large research group and assist/mentor graduate students. The PDF candidate will be expected to apply and obtain fellowships.

To Apply:
Send your CV, research statement, and list of three referees to: joanne.lemieux@ualberta.ca


[Post Date: December 04, 2018]

Title: Structural Biologist Brown University
Website: https://www.deaconesculab.com/

Description:
Structural Biologist Position at at Brown University, USA

The Deaconescu Lab at Brown University has one opening for a structural biologist. The laboratory's interests lie primarily in stress responses, with particular emphasis on responses to DNA damage and the mechanochemistry of DNA-based motors. We utilize a combination of biochemical, biophysical and structural techniques. (e.g. X-ray crystallography, small-angle X-ray scattering, transmission electron microscopy). For examples of work, please see Vemu et al. Science (2018), Le TT et al. Cell (2018), Deaconescu et al. Photochemistry and Photobiology (2017), Kutter et al. JMB (2016), Szyk et al, Cell (2014), Deaconescu et al., PNAS (2012), Szyk et al., NSMB (2012) and Deaconescu et al., TIBS (2013).

A successful candidate should have an established track-record of publications in peer-reviewed journals. Solid experience with protein biochemistry (including their purification from E.coli/yeast expression, functional characterization and assay development) is desirable. Prior knowledge of crystallography and/or single-particle electron microscopy is essential. Crystals/data at various stages of the structure determination process are available for immediate work. Responsibilities include crystal freezing, data collection and processing, obtaining and interpreting maps (X-ray or cryo-EM), model building, refinement and deposition of structures. Additionally the candidate will participate in the teaching and training of other lab members. Overall responsibilities and compensation will depend on qualification and performance.

Must be highly motivated and work independently as well as in a team. Excellent spoken and written English are required. New Ph.D. graduates are encouraged to apply.

Interested candidates should send a CV, one page research experience summary and contact information for three references to alexandra_deaconescu@brown.edu. Salary and starting date are negotiable. Brown University, an Ivy League school, is located less than one hour away by train from Boston.


[Post Date: December 04, 2018]

Title: Position at University of Bergen
Website: https://www.jobbnorge.no/ledige-stillinger/stilling/161277/postdoctoral-fellow-3-years-for-hit-discovery-for-riboswitches

Description:
Open position at the University of Bergen (Norway) for hit discovery for the TPP riboswitch with experience in at least one of the following areas:

- In vitro transcription of RNA
- HTS assay development
- X-ray crystallography of macromolecules
- development of small molecule binding assays using SPR
Additional experience in any of the following fields will be an advantage:
- structure-based ligand design using computational methods
- diffraction data collection at synchrotron beamlines
- work experience in a multidisciplinary team including medicinal chemists and biologists

More information can be found at the link.


[Post Date: December 03, 2018]

Title: Computational Structural Biologist
Website: https://www.fmi.ch/Careers/JobDetails.html?jobID=246

Description:
The Friedrich Miescher Institute for Biomedical Research (FMI) seeks an expert in Computational Structural Biology with a strong background in state-of-the-art approaches to structure solving, including low-resolution X-ray structures, model building and refinement. The FMI is a world-leading research institute located in Basel, Switzerland, focusing on fundamental questions of medical relevance. Research groups at the FMI use both X-ray crystallography and single-particle cryogenic electron microscopy for determining the structures of macromolecular complexes.

Candidates should have a PhD degree in structural biology or a related field. Responsibilities include obtaining and interpreting maps (X-ray or cryo-EM), model building, refinement and deposition of structures. Additionally the candidate will participate in the teaching and training of PhD students and postdocs. Overall responsibilities and compensation will depend on qualification and performance.

Closing date for applications is January 10, 2018

For further details and information on how to apply at the link.


[Post Date: December 03, 2018]

Title: Group Leader Structural Biology or Biochemistry

Description:
Viva Biotech, located in Shanghai, China, is specialized in structure-based drug discovery providing preclinical drug discovery research services to global pharmaceutical and biotech companies. We have opening for program leader in structural biology and biochemistry. Anyone who is interested in the position, please send CV to jin.gao@vivabiotech.com.

Job title: Group Leader in Structural Biology or Biochemistry

Job description

We are seeking a highly motivated individual with experience in protein biochemistry and structural biology. Candidates will lead the structural biology team to carry out the biochemistry studies and/or gene-to-structure studies which elucidate the interactions between small molecules/peptides and their targets. Experiences with protein expression and purification, excellent interpersonal and managerial skills, team player with excellent written and verbal communication skills and proficiency in structure biology related software. Excellent communication skill in English; 3-5 years working experiences with in US or Europe.

Qualifications

1) Ph.D. in crystallography or protein biochemistry training with minimal 3-5 years’ working experience

2) Hands-on experience in protein crystallization, and protein expression and purification is optional.

3) Proficient in structure biology related software is plus.

4) Demonstrated managerial skill to guide groups through corporate change and growth.

5) Excellent verbal and writing skills in both English and Chinese are mandatory.

6) Strong communication skills and client interaction are required.


[Post Date: November 29, 2018]

Title: Postdoc University of Oxford
Website: https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_search_package.search_form?p_company=10&p_internal_external=E

Description:
We are looking for highly motivated and talented Postdoctoral Scientist to join the research group of Professor Catherine Porcher (WIMM, University of Oxford, UK) to characterise and solve the structure of a multiprotein complex involved in the transcriptional regulation of blood stem cell development in normal and malignant conditions.

This exciting project, at the forefront of its field, is a collaboration with Dr Denis Ptchelkine leading structural biology research at the MRC Weatherall Institute of Molecular Medicine. It will employ molecular, biochemical, biophysical and cryo-EM studies. Key residues involved in protein/protein and protein/DNA interactions will be identified and functionally analysed. This high impact study will provide essential details for a mechanistic understanding of the transcriptional activities of this blood stem cell-specific complex.

Please apply via the link above. Vacancy ID: 138079


[Post Date: November 29, 2018]

Title: Postdoc Structural Biochemistry

Description:
Postdoctoral research fellow in Structural Biochemistry
Duties

Structural and functional characterization of enzymes involved in uracil and thymine degradation and of proteins involved in pathway regulation

Entry requirements
A person is eligible for a position as postdoctoral research fellow if he or she obtained a PhD after 2010 at an academic institution other than Uppsala University.
We are seeking a motivated researcher to join an ongoing research project studying the function, structure, evolutionary adaptation and regulation of enzymes involved in two distinct pathways of pyrimidine degradation. The experiments will involve a broad range of techniques, such as protein expression/purification, site-directed mutagenesis, enzyme kinetics, interaction analysis, structure determination by X-ray crystallography and/or cryo-electron microscopy, and computational biochemistry.

The ideal candidate will hold a recently awarded Ph.D. in biochemistry, biological sciences or a related discipline. Applicants should have a background in biochemistry or protein chemistry, and possess experience with cloning and protein expression/purification techniques. Biochemists who would like to learn structural biology are encouraged to apply. Previous experience in bioinformatics, protein crystallography, cryo-EM, or mammalian cell culturing is a plus. Candidates that are highly motivated, creative, excellent team players, and with a good track record with at least two publication as first author are expected. This project is fully funded via a fellowship stipend for 2 years and also welcomes international exchange scholars to apply.

Application process
An employment application must contain the following documents in English:
• A personal letter with a short description of yourself and the reasons why you are interested in the position
• A complete curriculum vitae, including the date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work & previous experiences (no more than one page)
• Authorized copies of degrees and diplomas.
• Names and contact details of at least two scientists that have offered to act as references for you must also be included, with a clear indication of their relationship to you.
• Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline)

The application is to be submitted via email to Doreen.Dobritzsch at kemi.uu.se latest on December 15, 2018.

The research program in biochemistry covers basic and applied research that spans a wide area, including enzymology, molecular cell biology, biophysics, structural biology, bioorganic synthesis and computer-based modeling. Many projects are run in collaboration with international research groups and in close cooperation with industry.

You can find more information about us here: http://www.kemi.uu.se/research/biochemistry/

Uppsala University is an international research university focused on the development of science and education. Our most important assets are the individuals, who with their curiosity and their dedication make Uppsala University one of Sweden’s most exciting workplaces. Uppsala University has 40,000 students, 7,000 employees and a turnover of SEK 6,5 billion. University strives to provide a workplace that has approximately the same number of women and men, is free of discrimination and offers equal opportunity to everyone.

The department of Chemistry – BMC is located within the Biomedical Center in Uppsala. We conduct teaching and outstanding research in areas of Analytical Chemistry, Biochemistry, Organic Chemistry and Physical Chemistry. Research education is given within all these subjects. We have interfaces towards pre-clinical biomedicine and the clinic, pharmacy, physics and materials science. The department has approximately 140 employees, and of them around 40 PhD students and 10 Professors.

For temp agencies and recruiters, and to salespersons: We politely, yet firmly, decline direct contact with
temp agencies and recruiters, as well as those selling additional job announcements.

Contact person: Doreen Dobritzsch-Lohkamp
Type of employment : Postdoctoral research fellow
Working hours Full time
Last application date 2018-12-15


[Post Date: November 23, 2018]

Title: Postdoc CNIO SPain

Description:
We are looking for a highly motivated postdoctoral researcher with experience in protein crystallography and molecular biology/protein production. The hosting lab is the Crystallography & Protein Engineering Unit at the Spanish National Cancer Research Center (CNIO). This is a multidisciplinary institute located in Madrid (Spain) with outstanding facilities for basic/clinical/translational research offering an international working environment.

The candidate will work on a project that aims on the structural characterization of bispecific antibodies.

The position is scheduled to start in the first trimester of 2019 and is funded for 22 months, although it may be extended. The candidate will be hired under standard CNIO contract conditions which includes Health Insurance benefits.

To apply for the position, please submit your CV, and the contact of three references in a single PDF to the following email address: imunoz@cnio.es


[Post Date: November 19, 2018]

Title: Research Technician University of Leicester
Website: https://jobs.le.ac.uk/vacancies/652/research-technician.html

Description:
A 2-year research technician position is available in my lab, to provide support to a research project funded by the Wellcome Trust. The project will investigate the structure of protein-DNA complexes operating in DNA replication and repair, and will involve the use of a range of techniques in the fields of bacterial cell culture, protein expression and purification and preparation of samples for Electron Microscopy and other biophysical techniques.

[Post Date: November 15, 2018]

Title: Research Assistant University of Frankfurt

Description:
We are currently recruiting a research assistance to work in Biotechnology/Molecular biology to support our structural biology and chemical biology pipeline. This position requires Bachelor/Master degree or comparable degree as technical assistant with a basic knowledge and hands-on lab experience in molecular biology (and preferably, not essential, protein production). The group offers international working environment, and therefore a knowledge in English language for communication would be essential. The position (on the german-academic scale ‘kleine’ E9* TV-G-U) is available immediately to work at the SGC based at the University of Frankfurt on a full-time basis and is up to 30th June 2020.

For full job description in English, please see the attachment. For german version: https://www.jobvector.de/jobs-stellenangebote/biologie-life-sciences/technische-assistenz/technischen-assistentin-assistenten-kleine-e9-tv-g-u-109837.html

For those who are interested, please apply by sending CV, a cover letter stating career interests, and contact addresses of at least two referees in a single PDF to the following e-mail address: Knapp@pharmchem.uni-frankfurt.de

Applications should be made by 21st December 2018.


[Post Date: November 15, 2018]

Title: Postdoc University of Chicago

Description:
Postdoctoral Position in Cellular Communication

Applications are invited for an immediate opening at the Cellular Communication Group with Dr. Demet Araç, at the Department of Biochemistry and Molecular Biology, University of Chicago (http://arac.uchicago.edu).

We are interested in understanding how cellular communication is mediated by cell surface receptors at the molecular level. The following papers describe the current direction of our research program:

• Structural basis for teneurin function in circuit-wiring: A toxin motif at the synapse. Li, Shalev-Benami, Sando,…, Südhof, Skiniotis, Araç. Cell (2018)

• Structural basis for regulation of GPR56/ADGRG1 by its alternatively spliced extracellular domains. Salzman, Ackerman , … , Koide, Araç. Neuron (2016)

Applications from a range of backgrounds including biochemistry, molecular biology, and cell biology are invited. Required skills include molecular cloning and protein biochemistry. Experience in protein expression/purification, structure determination, and GPCR signaling pathways are a plus.

Our laboratory is located at the University of Chicago, and is affiliated with the Department of Biochemistry and Molecular biology (http://bmb.uchospitals.edu/) and the Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior (http://neuroscience.uchicago.edu/grossman-institute/). The researcher recruited through this project will have the opportunity to visit and collaborate with interdisciplinary scientists on campus (https://www.uchicago.edu/).

Highly motivated candidates with a strong track record of publications should send an application package with research interests, full CV with experimental skills listed in detail, names and contact information of 3 references to:

Prof. Demet Araç
arac@uchicago.edu

The University of Chicago is an Affirmative Action/Equal Opportunity/Disabled/Veterans Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran status or status as an individual with disability.


[Post Date: November 14, 2018]

Title: Postdoc Lawrence Berkeley Laboratory
Website: https://lbl.referrals.selectminds.com/jobs/crystallography-postdoctoral-scholar-1279

Description:
Lawrence Berkeley Laboratory
Postdoctoral Researcher
Job ID: 85784
Division: Molecular Biophysics & Integrated Bioimaging (Joint BioEnergy Institute) Date Opened: 11/1/2018

Summary: A postdoctoral position is immediately available to study the structure and function of macromolecular complexes and enzymes using biochemical, X-ray crystallographic and electron cryo-microscopy (cryo-EM) methods. The biological systems to be studied are:

- Glycosyl transferases responsible for the synthesis of hemicelluloses in plants
- Novel glycosyl hydrolases that are able to breakdown cellulosic material for biofuels production
- Enzymes involved in lignin biosynthesis, degradation and valorization
- Secondary metabolite and natural product enzymes

This position will be part of the Structural Biology group of the Technology Division at the Joint BioEnergy Institute (JBEI) in Emeryville, California. To learn more about JBEI visit: http://www.jbei.org/

Duties: The successful candidate will have experience characterizing enzymes using biochemical techniques, and using crystallographic methods. Familiarity with cryo-EM methods would be helpful, but not essential. Robotic hardware for performing crystallization trials and imaging results are available. Crystals will be characterized and data collected using the beamline resources of the Berkeley Center for Structural Biology at the Advanced Light Source. For appropriate systems cryo-EM data will be obtained using in-house microscopes, the Bay Area Center for Cryo-EM, and other national user facilities.

Qualifications: a Ph.D. in biochemistry, molecular biology, structural biology, chemistry or a related field. Demonstrated experience of scientific research using biochemistry techniques including enzymatic assays, and crystallographic methods. Experience with macromolecular crystallization techniques. Experience with cloning methods and protein purification methods would be helpful. Strong problem solving skills. Solid interpersonal skills and the ability to work in a team environment are critical.

This is a full time, 2 years, postdoctoral appointment with the possibility of renewal based upon satisfactory job performance, continuing availability of funds and ongoing operational needs. You must have less than 3 years paid postdoctoral experience. Salary for Postdoctoral positions depends on years of experience post-degree.

Berkeley Lab (LBNL) addresses the world’s most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab’s scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy’s Office of Science. Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status.

To apply visit https://lbl.taleo.net/careersection/2/jobsearch.ftl?lang=en and search for the job number 85784 or visit:

https://lbl.referrals.selectminds.com/jobs/crystallography-postdoctoral-scholar-1279


[Post Date: November 14, 2018]

Title: Research Scientist

Description:
Research Scientist position at UT Health Science Center, San Antonio, TX

Job Summary:
The laboratory of Dr. Yogesh Gupta (http://ccri.uthscsa.edu/YGupta.html) at Greehey Children’s Cancer Research Institute, University of Texas Health at San Antonio, TX is seeking an enthusiastic scientist to study structure and function of protein-nucleic acid complexes.

Job Duties:

1. Express human proteins with relevance to cancer from bacterial, insect, and mammalian cells. Scale up the culture volume to produce these potential drug targets and perform their biochemical characterization by various cell enzymatic assays. Perform co-crystallization and determine the structures of protein-nucleic acid complexes using X-ray crystallography and other biophysical methods.

2. Develop, design, and perform cancer cell biology experiments using cell imaging, tissue culture, FACS, mice, Cas/CRISPR knock out methods to characterize new signaling pathways. Perform data analysis and interpret results. Review progress and present results regularly to PI.

3. Assist PI in preparation of research reports, manuscripts, papers and grant proposals for presentation and publication. Research current scientific literature for novel or improved research protocols; work closely with the PI, other lab staff concerning scientific, research and administrative matters

Preferred Qualifications:
Ph.D. in cell biology, cancer biology, biochemistry/structural biology with relevant experience in cancer cell models, pathways and drug discovery.

Salary is competitive. San Antonio offers affordable cost of living and there is no state income tax in Texas.

Submit your application to

https://uthscsa.referrals.selectminds.com/jobs/research-scientist-600

The Greehey Children’s Cancer Research Institute is a unique specialized cancer research center focusing on basic and translational research in childhood cancer and occupies a state-of-the-art 100,000 sq. foot research facility on the university’s Greehey Academic and Research Campus.

San Antonio is the nation’s seventh largest city and is located at the edge of the beautiful Texas Hill County. San Antonio offers a rich, multi-cultural community, affordable cost of living, excellent weather and a thriving biomedical industry.

All Postdoctoral appointments are designated as security sensitive positions. The University of Texas Health Science Center at San Antonio is an Equal Opportunity/Affirmative Action Employer including protected veterans and persons with disabilities.


[Post Date: November 12, 2018]
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