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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.

Title: Postdoc University of Oxford

THREE Wellcome Trust funded postdoctoral fellowships are available in Peijun Zhang lab at the University of Oxford (https://www.ndm.ox.ac.uk/principal-investigators/researcher/peijun-zhang):

1) Structural mechanisms of HIV-1 restriction by capsid-sensing host proteins;
2) Correlative cryo super-resolution fluorescence microscopy and cryoET of HIV-1 and host interactions;
3) Structural mechanism of HIV-1 inhibition by SERINCs;

Zhang lab combines structural methodologies, in particular cryoEM and cryoET, with biochemistry and functional studies, in conjunction with molecular-dynamics simulations, to gain new insights into the mechanisms of HIV-1 inhibition by host cell factors. The Division of Structural Biology in Oxford has excellent facilities for molecular and cellular cryoEM/ET and state-of-the-art cryo-fluorescence microscopy and high performance computing. We are also closely connected to the UK national cryoEM center, eBIC at the Diamond Light Source (http://www.diamond.ac.uk/Science/Integrated-facilities/eBIC.html).

You must be highly motivated, hold a PhD in biophysics/structural biology or equivalent, and have a demonstrated track record in conducting high quality original research. Knowledge in cryoEM/ET and protein biochemistry, and experience in structural biology (posts 1&3), or live-cell fluorescence microscopy (posts 2&3) are essential.

Online applications are open (closing date: 07-Aug-2017)

Postdoctoral Research Fellow in HIV-host interactions

Postdoctoral Research Fellow in Correlative Microscopy

Postdoctoral Research Scientist in STRUBI

For details, please contact Peijun Zhang at peijun@strubi.ox.ac.uk

[Post Date: July 24, 2017]

Title: Postdoc Boston Children's Hospital

A postdoctoral position is available immediately in Dr. Bing Chen’s laboratory at Boston Children’s Hospital/Harvard Medical School.

The ongoing projects include 1) biochemical and structural studies to elucidate molecular mechanisms of how HIV-1 enters host cells, 2) design and production of HIV-1 envelope-based immunogens, and 3) development of antiviral therapeutics.

For our recent publications, please see:
Cai et al., Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4477-4482. (https://www.ncbi.nlm.nih.gov/pubmed/28396421)
Dev et al., Science. 2016 Jul 8;353(6295):172-5. (https://www.ncbi.nlm.nih.gov/pubmed/27338706)

Chen et al., Science. 2015 Jul 10;349(6244):191-5. (https://www.ncbi.nlm.nih.gov/pubmed/26113642)
A strong background in protein biochemistry and/or structural biology is required. We are particularly interested in those who are highly motivated and willing to tackle difficult problems. Applicants should send a cover letter, CV, and contact information of three references to Bing Chen (bchen@crystal.harvard.edu).

[Post Date: July 24, 2017]

Title: Postdoc Rutgers School of Dental Medicine
Website: http://xtalsmgddp.wixsite.com/parasharlaboratory

Postdoctoral Fellow Position

Parashar laboratory at Rutgers School of Dental Medicine is currently seeking a highly motivated, creative individual with strong interest in the structure-function studies of proteins regulating bacterial signaling.

• Ph.D. in Biochemistry, Molecular Biology, Structural Biology, or a related field
• Experience with cloning, protein expression, and protein purification methods
• A sound understanding of methods and approaches relating to macromolecular crystallography preferred
• Ability to plan and carry out research projects independently
• Ability to work on own initiative and take personal responsibility for delivery of work
• Excellent problem solving, interpersonal, communication and presentation skills
• A working knowledge of bacterial genetics and computational modeling of protein-ligand interactions preferred

• Performing experiments for cloning, protein expression, and purification of proteins for biochemical and structural studies; robotic screens for crystallization; optimizing crystallization conditions; and collecting and analyzing diffraction data.
• Performing model building and structure refinement.
• Maintaining laboratory equipment to meet unique needs of the research activity
• Assisting with preparation of grant proposals, presentations and publications
• Actively seeking new collaborative projects within the department and externally
The Rutgers University Newark campus is well equipped with state-of-the-art equipment for molecular biology, protein purification, and crystallography, including crystallization robot, crystal imaging system, and X-ray generator. Please visit Parashar Laboratory website for more information. Applicants should send a cover letter, a CV, a list of publications, a summary of research experience and interests as well as the names and contact information of three references. The information should be sent via e-mail to parasharvj@gmail.com with the subject line “Postdoctoral Position Applicant”.

Rutgers University is an AA/EEO employer. All applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, disability or protected veteran status.

[Post Date: July 18, 2017]

Title: Postdoc Karolinska Institutet

The research group of Luca Jovine at Karolinska Institutet has an opening for a postdoctoral fellow to study protein complexes involving TGF-beta superfamily coreceptors, with a focus on endoglin/CD105 - a key human glycoprotein involved in hereditary hemorrhagic telangiectasia type 1 (HHT1), preeclampsia and tumor angiogenesis. Parallel studies are also ongoing on a number of structurally related biological systems mediating fertilization as well as protection from bacterial infection.

For further information about our laboratory and recent examples, please see http://jovinelab.org and:

Saito et al. Cell Rep. 19(9):1917–28 (2017) [ http://www.cell.com/cell-reports/fulltext/S2211-1247(17)30636-8 ]

Raj et al. Cell 169(7):1315–26 (2017) [ http://www.cell.com/cell/fulltext/S0092-8674(17)30594-9 ]

Bokhove et al. Proc. Natl. Acad. Sci. USA 113(6):1552-7 (2016) [ http://www.pnas.org/content/113/6/1552.long ]

The Department of Biosciences and Nutrition of Karolinska Institutet has state-of-the-art equipment for protein expression and purification, sample characterization (microscale thermophoresis, SEC-MALS) and in house X-ray/EM data collection (Rigaku Compact HomeLab with PILATUS 200K detector; http://ki.se/en/bionut/center-for-high-resolution-electron-microscopy-em). Frequent access to various synchrotron sites, as well as access to the newly established Cryo-EM Swedish National Facility (https://www.scilifelab.se/facilities/cryo-em/), are also available. With their close integration of academic and clinical research, KI and the Center for Innovative Medicine (CIMED; http://cimed.ki.se ) - to which our group also belongs - offer a highly international and collaborative environment for biomedical studies.

Candidates should have (or will be soon awarded) a PhD degree and must have significant experience in studying protein-protein interactions, both biochemically and using either X-ray crystallography or single-particle cryo-EM. Proven experience with the latter and/or protein expression in eukaryotic cells will be a significant advantage. At least one first author paper in a high quality international peer-reviewed journal, fluency in English (both written and oral), good team spirit and a very strong personal drive to excel in science are required.

For more information about this position and to submit an application through the KI MyNetwork recruitment system, please see:


[Post Date: July 13, 2017]

Title: Postdoc University of Texas Houston Medical School

The position

A NIH-funded postdoctoral position is immediately available in Center for Membrane Biology, Department of Biochemistry and Molecular Biology, University of Texas McGovern Medical School at Houston ( https://med.uth.edu/bmb/research-centers/center-for-membrane-biology/ ). In collaboration with Dr. John Spudich’s group, the researcher will work in the lab of Dr. Lei Zheng to study the structure of channel rhodopsin proteins using X-ray crystallography and cryo-electron microscopy approaches. See the link paper for the project info https://www.ncbi.nlm.nih.gov/pubmed/26113638

The candidate

Qualified candidates should have a recent Ph.D. degree and a solid and documented background in structural biology, biochemistry and/or biophysics. Candidates with extensive experience of membrane protein expression, purification are highly encouraged to apply. He/she also need to be self-motivated and is willing to work in a collaborative environment.

Interested candidates should send a CV, one page research experience summary and contact information for three references to lei.zheng@uth.tmc.edu . Salary will compensate based on NIH standard and candidate’s experience. Starting date is negotiable.

[Post Date: July 12, 2017]

Title: PhD Positions

Two PhD positions at the Interfaculty Institute of Biochemistry

We offer two PhD positions in the group of Professor Stehle at the Interfaculty Institute of Biochemistry in Tübingen. Our group is interested in the atomic details of interactions between pathogens and hosts in order to describe the mechanisms of pathogen engagement of target cells and to provide a basis for vaccine and drug design.

The successful candidates will work on the structural and functional characterization of virus-glycan interactions and on the structural and functional analysis of enzymes involved in cell wall synthesis and degradation in pathogenic bacteria, respectively. We are searching for highly motivated individuals with a Master degree in a relevant field (e. g. biochemistry or chemistry). The ideal candidates will have profound practical and theoretical knowledge in construct design and optimization, protein production and purification. Experience in crystallization, structure determination and other biophysical methods is an advantage. We expect excellent communication skills, willingness to work in a team, a strong dedication and motivation and the ability to design, plan and interpret experiments in an independent manner. Fluency in English is expected and a good working knowledge of German is a plus but not mandatory.

The salary will be based on German federal TV-L 13 (65%). The positions are fully funded and available immediately. Applications will be considered until 18th August 2017. The University of Tübingen is an equal-opportunity employer. Applications of women are explicitly encouraged. Applications including contact information (E-mail, phone, or Skype), CV, research experience, copy of the Master degree certificate, and contact information of two persons for references should be send as single pdf document (max. size 3 MB) to thilo.stehle[at]uni-tuebingen.de.

[Post Date: July 10, 2017]

Title: Postdoc Houston Texas Medical Center

A CPRIT funded postdoctoral position on single particle cryo-EM is available at Houston Texas Medical Center. The project will be led by the Dr. Mien-Chie Hung group at the University of Texas MD Anderson and will involve collaborations with Dr. Zhao Wang group (Baylor College of Medicine). We are looking for a creative and energetic colleague to study on the structure of antibodies-bound immune checkpoint ligand/receptor, which play critical role in tumor-associated immune escape in cancer cells. A sharp analytical mind and the ability to work in a group are essential. The center at BCM has expertise spans the entire discipline, including experimental and computational aspects of high-resolution single particle analysis of both soluble and membrane proteins as well as CryoET of both purified material and cells.

The candidate must have a PhD (or will shortly be awarded) with experience in protein/complex expression and purification. Applicants with backgrounds in the following fields are encouraged to apply: X-ray crystallography, physics, biochemistry, and biology. Submit a CV with 3 references for consideration to zhaow@bcm.edu and mhung@mdanderson.org

[Post Date: July 09, 2017]

Title: Postdoc University of Milan

Structural Biology Postdoctoral Position in Milan, Italy

A 2/3 year Postdoc position is available in the Structural Vaccinology division of the Structural Biology Unit run by Prof. Martino Bolognesi at the Department of Biosciences (University of Milan). The hired Postdoc will carry out the recombinant production, crystallisation and 3D structure determination of protein antigens from two parasites, Schistosoma mansoni and Trypanosoma cruzi, responsible for Schistosomiasis and Chagas disease, respectively. Both pathogens are two of several pathogens that are emerging in Lombardy, one of the most affluent areas of Italy, due to an increase in immigration. The aim of the project is to develop new diagnostic tests for on-site use in hospitals and refugee centres.

In this context, 3D structures will serve as the basis for in silico epitope mapping methods to guide subsequence computer-aided epitope peptide design for immunodiagnostic development based on epitope peptide microarrays. The project is highly multi-disciplinary and involves nine partners from the Lombardy region, including academic and industrial partners and is funded by the Lombardy Council.

The candidate must have a PhD (in biochemistry or similar) and a good background in molecular biology and recombinant protein production and purification techniques. Experience in protein crystallography and immunology will be of advantage. The candidate must work well with others. Participation in group meetings, departmental seminars and attendance at international conferences and courses will be required. The candidate must be highly motivated. Good written and spoken English is essential.
For more information please contact: Dr. Louise Gourlay (louise.gourlay@unimi.it) or Prof. Bolognesi (martino.bolognesi@unimi.it).
Position start date: negotiable (no later than 1st October).

[Post Date: July 05, 2017]

Title: Postdoc Aarhus University

Postdoctoral position in Structure and Function of Sugar Transporting Membrane Proteins

We are looking for a highly skilled and motivated postdoc with an interest in working on sugar transporting membrane transporters and with a proven track record in the area of structural and/or functional analysis of membrane proteins. The position is funded from the ERC intially as a one year position. An extension can be possible for up to a total maximum of 4 years employment as a postdoc. The position will be open from fall 2017.

The position
The position seeks to strengthen ongoing activities in the laboratory of Assistant Professor Bjørn Panyella Pedersen, related to the function and mechanism of sugar-transporting membrane proteins (mbg.au.dk/bpp). For further details on the position, please contact Bjørn P Pedersen (bpp@mbg.au.dk).

The candidate
A successful candidate has a relevant Ph.D. degree and a solid and documented background in structural biology, biochemistry and/or biophysics. Experience with membrane protein expression and purification, in particular from S. cereviciae is favored, and the candidate must demonstrate an ability and interest to work with membrane proteins with a structural aim. Finally, applicants should be ambitious, show strong collaborative skills, and should also be able to take initiatives and responsibility within the work environment.

The Department of Molecular Biology and Genetics
The Department of Molecular Biology and Genetics is part of the Faculty of Science and Technology, Aarhus University and comprises research within the areas Molecular Medicine, Structural Biology, Systems Biology, Plant Molecular Biology and Quantitative Genetics. There are currently 220 full time scientific staff and 140 PhD students. The department is responsible for two educations: Molecular Biology and Molecular Medicine with yearly uptake of 160 students in total. Please refer to http://mbg.au.dk/ for further information about The Department of Molecular Biology and Genetics and to http://scitech.au.dk/ and http://www.au.dk/ for information on Science and Technology and Aarhus University, respectively.

Formalities and salary range
Science and Technology refers to the Ministerial Order on the Appointment of Academic Staff at Danish Universities under the Danish Ministry of Science, Technology and Innovation.
The application must be in English and include a curriculum vitae, degree certificate, a complete list of publications and information about current research activities and motivation.
Appointment shall be in accordance with the collective labour agreement between the Danish Ministry of Finance and the Danish Confederation of Professional Associations. Further information on qualification requirements and job content may be found in the Memorandum on Job Structure for Academic Staff at Danish Universities. (in Danish).
Salary depends on seniority as agreed between the Danish Ministry of Finance and the Confederation of Professional Associations.

All applications must be made before 15.08.2017 online at

[Post Date: July 05, 2017]

Title: Postdoc Yale University
Website: https://medicine.yale.edu/physiology/faculty/satinder_k_singh-2.profile

A postdoctoral position at Yale University School of Medicine is available immediately for highly motivated, creative individuals with a strong interest in the conformational dynamics of neuronal membrane proteins. The lab employs a combination of steady-state flux kinetics, radioligand binding, structural biology (macromolecular crystallography and cryoEM) and HDX-MS (hydrogen-deuterium exchange mass spectrometry) in nanoscale lipid bilayers.

The laboratory is located in renovated space in the Department of Cellular and Molecular Physiology in a highly collaborative environment. We have state-of-the art facilities for expression, purification, reconstitution, and functional characterization of membrane proteins. The lab also has regular access to Waters Synapt G2 Q-TOF mass spectrometers equipped with an HDX-enabled NANO UPC.

Candidates must hold (or soon expect to hold) a recent Ph.D. (less than 1 year) in biochemistry, biophysics, or related field with at least some expertise in HDX-MS (as evidenced by publications in the field), and have an excellent publication record overall. A strong background in recombinant DNA methods, protein expression, purification, and biochemical/biophysical characterization is required. Applicants with experience in membrane proteins, nanodiscs, some structural biology, and HDX-MS are preferred. A creative approach to developing new functional assays and an ability to troubleshoot experimental obstacles are essential. S/he must be capable of working independently and as part of a collaborative team.

The candidate must have an excellent command of oral and written English. In addition to compiling and analyzing data, s/he will be responsible for providing assistance in preparation of materials for publications and grant proposals. Those able to write and submit successful postdoctoral fellowship applications will have a significant competitive advantage.

Applicants should send a CV, along with a summary of research interests and experience, and arrange to have 3 reference letters sent to Satinder K. Singh at satinder.k.singh@yale.edu.

For more information, please contact me via email.
Additional contact information is given below:

Satinder K. Singh, Ph.D.
Associate Professor of Cellular and Molecular Physiology
Yale University School of Medicine
333 Cedar Street, SHM B147
Lab room # SHM BE11/17
P.O. Box 208026
New Haven, CT 06520-8026
Office #: 203-737-6477
Fax#: 203-785-4951

[Post Date: June 29, 2017]

Title: Project Scientist NIH

The Roll-Mecak lab at the National Institutes of Health in Bethesda, Maryland is seeking to hire an expert researcher in the area of structural biology with emphasis on X-ray crystallography or electron microscopy of large multi-subunit complexes. Candidates should have expertise in solving de novo structures using X-ray crystallography or cryo-EM and extensive experience with eukaryotic expression systems, construct design and protein purification demonstrated through publications.

Duties of the Position:
• Express and purify various microtubule associated proteins to homogeneity
• Characterize them biochemically and solve their structures.
• Provide training to graduate students and postdoctoral fellows in structural biology techniques.
• Prepare results for publication, presentations, and grant proposals.

Basic Qualifications:
• A Ph.D. or equivalent degree in structural biology, biophysics, biochemistry, or a related field is required at the time of application.

Additional qualifications required by start date:
• Post-Ph.D. experience in biochemical reconstitutions and solving structures of challenging targets using either X-ray crystallography or cryo-EM .
• Excellent written and oral communication skills.

The position provides excellent salary and benefits. Salary will be
commensurate with experience and accomplishments. The initial appointment will be for one year with the possibility of renewal for a long-term position.

To apply please submit your cover letter, curriculum vitae, and contact information for three references to Antonina@mail.nih.gov

[Post Date: June 28, 2017]

Title: Postdoc University of Maryland

A postdoctoral position is available immediately to participate in an inter-disciplinary research program on structural immunology at the Institute of Human Virology of School of Medicine, University of Maryland, Baltimore, MD. Candidates are expected to work on ongoing research projects in structural biology aimed at understanding Fc mediated effector function of antibodies to HIV-1 and development of antibody-based therapeutics and novel vaccine concepts. Qualifications for the position include: strong research interest and experience in cell biology, functional analyses, biophysical and structural techniques (which may include a combination of: X-ray crystallography, computational chemistry, small-angle X-ray scattering and cryoEM) and excellent interpersonal/oral/written communication skills. Candidates need to be highly motivated individuals who enjoy working as part of a young, dynamic, collaborative and multidisciplinary team. Preference will be given to candidates with exceptionally strong experimental skills, a strong record of peer-reviewed publications and with experience in small-angle X-ray scattering and/or CryEM image reconstruction. Qualified candidates should have a doctorate in in the field of structural biology, biochemistry or immunology. New Ph.D. graduates are highly encouraged to apply.

Interested candidates should send a CV, one page research experience summary and contact information for three references to mpazgier@ihv.umaryland.edu. Salary and starting date are negotiable.

The University of Maryland, Baltimore is an Equal Opportunity/Affirmative Action Employer. Minorities, women, veterans and individuals with disabilities are encouraged to apply.

[Post Date: June 27, 2017]

Title: Postdoc & PhD Student Oulu, Finland

We have positions open in my group for a PhD student and for a postdoctoral researcher. The project focuses on structure and inhibition of ADP-ribosyltransferases. Information on our team and projects can be found from our web pages: http://www.oulu.fi/biocenter/groups/lehtio

More details regarding the open positions can be found in the following links. Application forms are available also through the links and applications are accepted only through the web-based system.

Postdoctoral position:

PhD student position:

[Post Date: June 26, 2017]

Title: Postdoc University of New Zealand

Postdoctoral and Ph.D. positions at the School of Biological Sciences University of Auckland

We are seeking well-qualified and highly motivated candidates for the position of a postdoctoral research fellow and a doctoral student to carry out a peptide-based drug-design project involving a multi-disciplinary approach. The project targets the interaction between endoplasmic reticulum (ER) chaperone ERp44 and the collagenous hormone adiponectin. Adiponectin, abundantly and exclusively secreted from adipocytes (fat cells), exerts a wide range of beneficial functions against obesity-associated pathologies and is a potent biotherapeutic. In the ER, ERp44 tightly regulates oligomerization of trimeric adiponectin subunits that are responsible for its insulin-sensitizing and anti-inflammatory properties. Under obesity-induced ER stress, expression of ERp44 is dysregulated resulting in part to sequestration of adiponectin in ER. The concomitant reduction in serum-circulating level of adiponectin can lead to insulin resistance and type2 diabetes. We are exploring the action of rationally designed peptides that may interfere in ERp44-adiponectin interaction as a means of mitigating the onset of metabolic syndrome in obesity.

The interdisciplinary project combines rationally designed peptide synthesis, biophysical characterization of the binding of these peptides with ERp44, including X-ray crystallography, and examination of their action in cellulo and in vivo (carried out by our collaborator Prof. Yu Wang at University of HongKong) towards elevating the level of circulating adiponectin. A 3-year funding from the Health Research Council of New Zealand supports this project for both the postdoctoral and the doctoral positions.

The selected postdoctoral candidate will have prior experience in peptide synthesis, biophysical techniques to examine protein ligand interactions, recombinant protein expression with an experience in Structural Biology as that involved in protein X-ray crystallography. The doctoral candidate should preferably have a background at least in one of the following disciplines: Structural Biology, biophysics or protein biochemistry.
The peptide synthesis will be carried out in an in-house state-of-the-art facility. The biophysical instrumentation suite includes ITC, DLS, Mass Spectrometry, NMR and CD. We have a modern in-house X-ray suite including two Mar detectors, cryo system and a crystallization robot. We also have direct access to the Australian Synchrotron facility.

Relevant publications:
1. Radjainia, M, Wang, Y and Mitra, AK. Structural polymorphism of oligomeric adiponectin visualized by electron microscopy. J Mol Biol, 2008. 381(2): 419-30.
2. Hampe, H, Radjainia, M, Xu, C, Harris, PWR, Bashiri, G, Goldstone, DC, Brimble, MA, Wang, Y, Mitra, AK. Regulation and Quality Control of Adiponectin Assembly by Endoplasmic Reticulum Chaperone ERp44. Journal of Biological Chemistry 2015. 290: 18111-1812.
3. Radjainia, M, Huang, B, Bai, B, Schmitz, M, Yang, SH, Harris, PW, Griffin, MD, Brimble, M A, Wang, Y and Mitra, AK. A highly conserved tryptophan in the N-terminal variable domain regulates disulfide bond formation and oligomeric assembly of adiponectin. FEBS J, 2012. 279(14):2495-507.
4. Harris PW, Hampe L, Radjainia M, Brimble MA, Mitra AK. An investigation of the role of the adiponectin variable domain on the stability of the collagen-like domain. Biopolymers. 2014 Jul;102(4):313-21

University of Auckland has a vibrant research environment and is the premier such Institute in New Zealand. Auckland is a multi-ethnic cosmopolitan city consistently ranked amongst the top ten cities in the world. New Zealand is well known for its scenic beauty.

For further information, please send a current CV and contact Dr. Alok K. Mitra, School of Biological Sciences, University of Auckland, Auckland, New Zealand. Tel: +64 09 923 8162, E.mail: a.mitra@auckland.ac.nz

[Post Date: June 25, 2017]
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