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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.

Title: Postdoc Aarhus University, Denmark
Website: http://www.pedersenlab.dk/source/bp_lab_postdoc_position.pdf

Postdoctoral position in Structure of Sterol Transporting Membrane Proteins at Aarhus University, Denmark.

The Pedersen group is looking for a highly skilled and motivated postdoc with an interest in working on sterol and hormone transporting membrane transporters and with a proven track record in the area of structural and/or functional analysis of membrane proteins.

The position will be open from fall 2018, and starting date is negotiable. Funding is available for at least 2 years of employment, with an automatic extension possible for up to a total maximum of 4 years.

The position:
The position seeks to strengthen ongoing activities in the laboratory of Bjørn P. Pedersen on structure, related to the function and mechanism of sterol-transporting membrane proteins (pedersenlab.dk). The laboratory's interest is the interplay between structure and function of transmembrane transport processes with a focus on metabolite uptake systems, and the methods uses are primarily crystallography, cryo-EM and biochemistry. The group is part of the Section of Structural Biology at Aarhus University.

The candidate:
A successful candidate has a relevant Ph.D. degree and a solid and documented background in structural biology, biochemistry and/or biophysics. Experience with membrane protein expression and purification is favored, and the candidate must demonstrate an ability and interest to work with membrane proteins with a structural aim. Finally, applicants should be ambitious, show strong collaborative skills, and should also be able to take initiatives and responsibility within the work environment.

All applications must be made online and received by 16/09/2018.

[Post Date: August 13, 2018]

Title: Postdoc Jagiellonian University in Krakow, Poland

We have a job opening for a highly-motivated postdoctoral fellow who holds a Ph.D. degree for no longer than five years.
The successful candidate will be involved in projects carried out in the newly established Structural Biology Core Facility at Jagiellonian University in Krakow, Poland.

Job offer website:
Laboratory website: http://www.mcb.uj.edu.pl/en/mpl

The ideal candidate should:
- hold a doctoral degree for no longer than 5 years
- have a strong expertise in structural biology (Macromolecular
Crystallography) and biochemistry
- Have excellent written and oral communication skills in English
- Have good presentation skills (ideally having presented on at least one international research conference)
- Enjoy working in a highly collaborative and interdisciplinary environment
- Enjoy scientifically supporting and actively interacting with other members of the lab
- Have published at least one publications as first author in an international peer reviewed journal

We offer:

- Position for three years with possible extension after the project ends
- Excellent training: In our diverse group you will be able to network
with international researchers, experience and learn new skills in
cellular & molecular biology.
- State-of the-art research center with access to the full suite of
equipment necessary for cell biology, molecular biology,
biochemistry and structural biology research and a network of
international collaborators in Europe and beyond.

Interested applicants should send a cover letter and CV with the names of
two references to Sebastian Glatt sebastian.glatt@uj.edu.pl

[Post Date: August 13, 2018]

Title: Postdoc Michigan State University
Website: https://bmb.natsci.msu.edu/faculty/jian-hu/

A postdoctoral research associate position in membrane protein structural biology/biochemistry is immediately available in the Department of Biochemistry & Molecular Biology at Michigan State University, East Lansing, MI, US. One major direction in Dr. Jian Hu’s laboratory is structural biology study of metal transporters important in medicine. Previously, we have solved the first crystal structure of the extracellular domain of a mammalian ZIP4 zinc transporter (Nature Communications, 2016) and the first full length ZIP metal transporter (Science Advances, 2017). By employing multidisciplinary approaches of structural biology, biochemistry, biophysics and cell biology, we are aiming to establish the structural basis and clarify the molecular mechanisms of metal homeostasis in eukaryotic cells. The MSU cryo-EM facility will be updated with a new transmission and scanning transmission electron microscope by the end of 2018. The laboratory is well funded by federal agencies, and the position can be supported up to four years based on mutual satisfaction. The other ongoing projects include biogenesis of the Ni-pincer cofactor, the PIPK lipid kinases and the calcium sensing receptor. To obtain more information, please visit our website (https://bmb.natsci.msu.edu/faculty/jian-hu/).

The successful candidate must be highly self-motivated with Ph.D. in structural biology, biochemistry, biophysics, molecular biology or related fields. Hands-on experience in membrane protein biochemistry is required. Experience in structural biology (x-ray crystallography/cryo-EM/NMR) is desirable, but not necessary. Interested individuals should submit a brief cover letter, CV, and the names and the contact information of three referees to Dr. Jian Hu by email: hujian1@msu.edu.

[Post Date: August 10, 2018]

Title: Postdoc Meharry Medical College

Postdoctoral position investigating the impact of genetic variations on three-dimensional structure/function of proteins available in the laboratory of Jamaine Davis at Meharry Medical College in Nashville, TN

There is an immediate availability in the laboratory of Jamaine Davis for an enthusiastic postdoc who is interested in the molecular recognition of protein complexes essential for genome maintenance. The successful candidate will investigate DNA repair protein structure and complex assembly mechanisms using X-ray crystallography and/or single-particle cryo-EM, in addition to performing functional assays. The work in the lab is generally geared towards developing a mechanistic understanding of the DNA damage response using functional and structural techniques. The ideal candidate for this position is a protein biochemist who has experience in X-ray crystallography and wants to gain experience in cryo-EM.

We are located on the campus of Meharry Medical College within vibrant Nashville, aka Music City. Nashville has been rated #12 on Forbes list of best places for businesses and careers. Our lab is also a member of the Center for Structural Biology at Vanderbilt University (http://structbio.vanderbilt.edu/faculty/davis.php),where we have access to the Vanderbilt Cryo Electron Microscopy Facility (V-CEM). The V-CEM facility houses high-resolution transmission electron microscopes (TEMs) and cameras needed to collect data for single particle analysis and tomography.

Qualifications and experience: Candidates should hold a Ph.D. in a relevant field and have a solid background in protein biochemistry. Candidates with prior experience in protein expression/purification, mutagenesis, structure determination (e.g., X-ray, NMR) and protein-nucleic acid interaction are preferred. Experience with cryo-EM is advantageous. Excellent verbal and written English communication skills, and ability to work in close collaboration with other researchers are required.

Qualified applicants should send a cover letter, CV, and the names of three references by email to Jamaine Davis at jdavis@mmc.edu.

[Post Date: August 07, 2018]

Title: Postdoc Diamond Light Source
Website: https://vacancies.diamond.ac.uk/vacancy/post-doctoral-research-associate-355285.html

Are you interested in probing and pushing the boundaries of long-wavelength macromolecular crystallography? Then read on…

We are seeking a highly motivated PDRA to join the I23 beamline team at Diamond Light Source (http://www.diamond.ac.uk/Instruments/Mx/I23.html) and carry out innovative research using long-wavelength macromolecular crystallography. As the beamline is tunable over a large wavelength range not accessible at any other MX beamline (down to ? = 5.9 Å), this position allows setting up novel experiments to push the boundaries of MX at synchrotrons. Potential projects are the investigation of the optimal wavelength for native phasing as function of crystal size, testing and improving of analytical absorption correction software based on X-ray tomography, evaluation of different data collection and processing / scaling protocols or establishing MAD experiments using the strong anomalous signal from the uranium M(V)-edge. Candidates are encouraged to indicate their personal research interest exploiting the unique capabilities of the instrument in the application.

More details can be found here:

[Post Date: August 07, 2018]

Title: Postdoc MD Anderson

At MD Anderson, we have been working to eliminate cancer for more than seven decades and are ranked as one of the top two hospitals in cancer care every year since 1990. One of our greatest strengths is our ability to translate today's most promising laboratory findings into tomorrow's new, more effective and less traumatic treatments.

We are recruiting exceptional national and international post-doctoral fellows to join our Structural Chemistry group, part of the Institute for Applied Cancer Science. Applicants must be extremely motivated and possess a strong background in structural biology, including protein expression and purification, crystallization, and X-ray crystallography. Experience using other biophysical techniques would be an advantage. We are seeking only the most dedicated individuals who will join us in our quest to discover, develop, and deliver more effective treatments to our patients. This is a unique opportunity to participate in project-driven drug discovery research within a highly respected academic and clinical setting.

We’re tackling cancer and neurodegeneration with a new plan — our Moon Shots Program
- one that aims to improve prevention, early detection and treatment. Our research engines fuel innovation along the way. And innovation, collaboration and scale get us there faster. They give us the framework we need for success, and speed up development for new and more effective care.

Our Mission is to integrate novel biological insights with drug discovery expertise to accelerate the development of innovative targeted therapeutics, both small molecules and biologics for unmet medical needs. Our work is conducted in an environment that brings together excellence in both academic and pharmaceutical discovery, as evidenced by recent publications.

Visit our platforms at https://www.mdanderson.org/cancermoonshots.html
Interested individuals should send a cover letter describing their research experience, and a curriculum vitae, to: MD Anderson Therapeutics Division (therapeutics@mdanderson.org)

[Post Date: August 03, 2018]

Title: HTS Specialist St. Jude
Website: https://careers-stjude.icims.com/jobs/3973/hts-specialist/job

The High Throughput Biosciences (HTB) Center is recruiting a senior-level scientist to serve as our in-house protein expert and to join our efforts in using high-throughput screening (HTS) for structure/target-based small molecule discovery (Job title: HTS Specialist). The HTS Specialist reports to the Director of the High Throughput Bioscience (HTB) Center and is expected to independently lead and implement collaborative projects; present and publish research results; and assist the Center Director in managing the daily operations of the Center.

The successful candidate will have extensive experience in molecular biology, protein biochemistry, and structural biology and a strong interest in learning, developing, and implementing new techniques related to high-throughput small-molecule drug discovery.

Experience in the following areas is a plus: protein purification, protein crystallography, docking, and biochemical and biophysical assay development, along with a strong publication record.

Please direct your questions, cover letter, current CV, and 3 letters of reference to Dr. Taosheng Chen (taosheng.chen@stjude.org).

The High Throughput Bioscience Center at St. Jude consists of members with advanced training in biology, chemistry, and engineering. We have professional experience in target identification and validation, assay development, high-throughput screening, laboratory automation, and management of scientific collaborations.

Minimum Education
Bachelor's or Master's degree in biology, chemistry, or a related field required. PhD in biological sciences with relevant postdoctoral training preferred.

Minimum Experience
Seven (7) years of relevant experience is required with a Bachelor’s degree.
Six (6) years of relevant experience is acceptable with a Master’s degree.
At least two (2) years of relevant experience is acceptable with a PhD.

Taosheng Chen, PhD
Member, Department of Chemical Biology and Therapeutics
Director, High Throughput Bioscience Center
St. Jude Children's Research Hospital
Memphis, TN, 38105-3678, USA

[Post Date: August 02, 2018]

Title: Postdoc University of Southern California

Postdoctoral Scholar Position on Investigating CRISPR Mechanism at University of Southern California, Los Angeles, California, USA

The Qin Laboratory in the Chemistry Department of the University of Southern California invites applications for postdoctoral scholar positions supported by funding from NIH and NSF. The work centers on investigating mechanisms of target recognition by the programmable CRISPR nucleases that are revolutionizing genome engineering. The projects use a combination of biophysical techniques, including spin-labeling and EPR (a specialty of the Qin lab, seehttp://pzqin.usc.edu/pzqhome/), fluorescence, and structural characterization. Candidates with prior experience on protein expression, mutagenesis, structural analyses (e.g., X-ray, NMR), and protein-nucleic acid interaction are particularly welcome. Strong writing and communication skills, as evidenced by first author publications, are highly desirable.

The appointment is available initially for three years contingent on satisfactory research progress. Funding starts in Fall 2018, and salary will commensurate with qualifications. To Apply, please email a cover letter, CV and contact information for three references to Professor Peter Qin, pzq@usc.edu

[Post Date: August 01, 2018]

Title: Postdoc University of Texas Medical Branch

Postdoctoral position in structural biology at the University of Texas Medical Branch (UTMB) to study the translation machinery

We have an immediate opening for a talented, highly motivated postdoctoral scholar in my laboratory at the University of Texas Medical Branch (UTMB) located in Galveston, TX, USA, to study the structure and function of ribosome functional complexes during protein synthesis (https://microbiology.utmb.edu/faculty/matthieu-gagnon). In particular, the successful candidate will be involved in the characterization of prokaryotic and eukaryotic ribosomes and other RNA/protein complexes involved in translation and its regulation using a combination of cryo-electron microscopy (cryo-EM), X-ray crystallography and biochemical techniques.

Basic qualifications:
• Ph.D. in structural biology, biochemistry, biophysics or a related field
• Practical skills in molecular biology, protein expression, purification and biochemical characterization
• Experience in structural biology, specifically cryo-EM and X-ray crystallography

The successful candidate will have an excellent track record and is expected to drive forward the projects, act semi-independently, compile, analyze and write up data for publication, and work co-operatively with others. More specifically, the candidate will:
• Establish the cryo-EM platform to image ribosome complexes
• Assist with the training of graduate students and postdocs and maintain laboratory inventory

Structural biology facilities at UTMB are outstanding (https://www.utmb.edu/core). Cryo-EM resources include a JEOL 2200FS cryo-EM microscope equipped with a DE20 direct electron detector for high-resolution imaging work and a liquid nitrogen autofilling system allowing at least week-long experiments, a cryo-microscope JEOL 2100, an FEI vitrobot cryo-plunger, a Leica EM-GP2 cryo-plunger, a Gatan Solarus plasma cleaner, and a soon-to-be available FEI Titan Krios microscope. X-ray crystallography resources include two X-ray area detector systems, a Phoenix crystallization robot, a Minstrel crystal imaging robot, and the Alchemist and epMotion liquid handling robots. Other state-of-the-art facilities include NMR, next-generation sequencing, molecular genomics, high-throughput screening, solution biophysics, optical microscopy and computational biology.

Ample opportunities exist at UTMB for interactions with centers of scientific excellence in structural biology and molecular biophysics, biodefense, molecular medicine, cancer biology, infectious diseases, environmental health, aging, and translational sciences (https://www.utmb.edu/centers). Moreover, UTMB boasts a renowned, vibrant and highly active community of infectious disease researchers and clinicians, providing ample opportunities for broader collaborations and development.

Review of applications will begin immediately and will continue until the position is filled. Interested applicants should e-mail their CV along with a cover letter briefly describing their research accomplishments, current research interests and contact information for three references in one PDF document to Dr. Matthieu Gagnon at magagnon@utmb.edu

[Post Date: August 01, 2018]

Title: Postdoc University of Goettingen

The Department for Molecular Structural Biology at the Georg-August-University Goettingen (http://www.uni-goettingen.de/msb) seeks to recruit a postdoctoral scientist in structural biology with a research focus directed towards the structure and dynamics of protein-RNA complexes.

The advertised position is suitable for candidates with strong expertise in the preparation of protein-RNA complexes as well as X-ray crystallography and/or single particle cryo-EM.

An initial contract of 2 years will be offered to the successful candidate.
The University of Göttingen is committed to increase the number of individuals with disabilities in its workforce and therefore encourages applications from such qualified individuals. Furthermore, the University of Göttingen seeks to increase the number of women in those areas where they are underrepresented and therefore explicitly encourages women to apply. The University of Göttingen is a family-friendly employer and promotes the compatibility of family and career.

Please send your application as single PDF file by E-mail to Prof. Dr. Ralf Ficner (rficner@uni-goettingen.de), Department of Molecular Structural Biology, GZMB, University Goettingen, Germany.

Closing date for applications: August 15, 2018.

[Post Date: July 31, 2018]

Title: Senior Purification Scientist Evotec
Website: https://recruitment.evotec.com/VacancyDetails.aspx?FromSearch=True&MenuID=QSAukis1tlc=&VacancyID=649

There is an opportunity to join the expanding Structural Biology team at Evotec based in the U.K as a Senior Scientist (Protein purification). Please see the advert in the link below. Interested candidates should apply directly through our website. Please do not send applications through to me directly. Closing date is 10th August and applicants must be eligible to work in UK. The position is for a 12 month contract.

[Post Date: July 30, 2018]

Title: Postdoc USC

Postdoctoral Scholar Position on Investigating CRISPR Mechanism at University of Southern California, Los Angeles, California, USA

The Qin Laboratory in the Chemistry Department of the University of Southern California invites applications for postdoctoral scholar positions supported by funding from NIH and NSF. The work centers on investigating mechanisms of target recognition by the programmable CRISPR nucleases that are revolutionizing genome engineering. The projects use a combination of biophysical techniques, including spin-labeling and EPR (a specialty of the Qin lab, see http://pzqin.usc.edu/pzqhome/), fluorescence, and structural characterization. Candidates with prior experience on protein expression, mutagenesis, structural analyses (e.g., X-ray, NMR), and protein-nucleic acid interaction are particularly welcome. Strong writing and communication skills, as evidenced by first author publications, are highly desirable.

The appointment is available initially for three years contingent on satisfactory research progress. Funding starts in Fall 2018, and salary will commensurate with qualifications. To Apply, please email a cover letter, CV and contact information for three references to Professor Peter Qin, pzq@usc.edu

[Post Date: July 30, 2018]

Title: Postdoc Structural Microbiology

Project description: A postdoctoral position is available in the research group of Assistant Prof. Charles Calmettes at the Centre INRS-Institut Armand Frappier in Laval (Greater Montreal, Canada) to work on a 5-years CIHR funded project. For this position we are looking for a talented, highly skilled, and motivated postdoc with a proven track record in the areas of structural biology and protein biochemistry. The successful candidate is expected to dissect the structure and function of bacterial proteins (membrane and soluble proteins) identified as potential new drug targets, using a combination of X-ray crystallography and biochemical techniques. The research project is a follow up study from our article entitled “Global landscape of cell envelope protein complexes in Escherichia coli”, recently published in Nature Biotechnology (2018).

The applicant must have a PhD in a relevant field, such as protein biochemistry, biophysics, membrane protein, or structural biology. Preference will be given to candidate with protein expression and purification skills, and with a solid knowledge in protein characterization and biophysical methods. Experience in X-ray crystallography is preferred but not mandatory. The applicant will be an enthusiastic scientist who demonstrates excellence, creativity, commitment to research, and effective communication skills. The Centre INRS-Institut Armand Frappier offers a French/English bilingual environment.

Salary range: To be eligible applicants must have completed their PhD degrees within the last 3 years. The salary range for the position is $40,000 to $50,000 per year.

Starting date: Review of applications begins immediately and will continue until the position is filled. Send your CV and a cover letter in PDF to charles.calmettes@iaf.inrs.ca. Successful candidates will be notified for interviews. Anticipated starting date is October 2018.

Institution: INRS–Institut Armand-Frappier Research Center, is a university dedicated to fundamental and applied research in the field of infectious diseases, immunity, and pharmaco-chemistry.

Questions? Pr Charles Calmettes, Ph.D.
E-mail : charles.calmettes@iaf.inrs.ca
Lab page:http://ccalmettes.profs.inrs.ca/ (English)
http://www.inrs.ca/charles-calmettes (French)

[Post Date: July 27, 2018]

Title: Postdocs SGX, Oxford

We have three positions available for membrane protein structural biologists at the SGC in Oxford in Prof. Liz Carpenter’s lab:

1. Membrane protein structural biology, pipeline and methods development position (closing date 23rd August)
2. Structural biology of human ion channels and ABC transporters (closing date 23rd August)
3. Structural biology of human ion channels, as part of a collaboration with Pharma (closing date 13th August)
The third post would involve work both in Oxford and Biberach in Germany

The group studies human integral membrane proteins involved in genetic disease. We work with geneticists to identify genes that are involved in neuropsychiatry, cancer, rare and metabolic disease and inflammatory diseases.
We aim to produce protein, assays and structures, as well as small molecule and protein binders. Through this work we aim to understand the role of these proteins in disease and thus promote the development of novel therapies.
We use both crystallography and electron cryo-microscopy for structure determination. The SGC and the University of Oxford provide an excellent working environment, with access to world class facilities for all structural biology, biochemical and biophysical studies.

Please follow the links below for more information:

1. Structural biology, pipeline and methods development position (closing date: 23rd August, interviews during the week starting the 3rd September):

2. Structural biology of human ion channels and ABC transporters(closing date: 23rd August, interviews during the week starting the 3rd September):

3. Structural biology of human ion channels, as part of a collaboration with Boehringer Ingelheim (closing date: 13th August):

If you have an questions about these posts please get in touch with me (liz.carpenter@sgc.ox.ac.uk).

[Post Date: July 27, 2018]

Title: Postdoc Albert Einstein College of Medicine

The Almo lab in the Department of Biochemistry at the Albert Einstein College of Medicine seeks applicants for a post-doctoral fellow to work on chemical and enzymatic approaches for the covalent modification of cell surface and secreted molecules, and biologics involved in immune regulation. The successful candidate will have extensive experience in covalent coupling chemistry and/or enzyme-mediated coupling approaches; for example, thiol and aldehyde-based chemistries, or SORTASE-mediated modifications. Familiarity with eukaryotic protein expression is desirable but not essential. This program seeks to develop efficient strategies for the attachment of imaging agents, affinity tags, small molecule toxins and other functionalities to a wide range of immune regulatory proteins for the realization of novel strategies to study and treat malignancies, autoimmune diseases and infectious diseases. The Almo lab offers an outstanding working environment with state-of-the-art infrastructure in high-throughput eukaryotic expression, functional annotation and structure determination, while the College is home to internationally acclaimed experts in modern immunobiology.

Interested candidates should contact Steven Almo (steve.almoeinstein.yu.edu). Please provide a CV, including the names of three references.


Founded in 1955, the Albert Einstein College of Medicine (Einstein) is one of the nation’s premier institutions for medical education, basic research and clinical investigation. A full-time faculty of some 2,000 conducts research, teaches, and delivers health care in every major biomedical specialty. The college has some 730 medical students, 193 Ph.D. students, 106 MD/Ph.D. students and 275 postdoctoral fellows.

Einstein’s major strength, in addition to training physicians and scientists, is its science. During fiscal year 2015, the faculty’s consistently high level of scientific achievement resulted in the awarding of more than $150 million in peer-reviewed grants from the National Institutes of Health (NIH).

Einstein is part of Montefiore Medicine Academic Health System, an integrated academic delivery system comprising seven campuses, including 8 hospitals, a multi-county ambulatory network, a new state-of-the art “hospital without beds”, a skilled nursing facility school of nursing, home health agency, and the state’s first freestanding emergency department. As the University Hospital for the Albert Einstein College of Medicine, Montefiore is a premier academic health system, employing Einstein’s clinical faculty and training Einstein’s medical students, over 1,300 residents, 420 allied health students, and 1,600 nursing students annually.

The Albert Einstein College of Medicine is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information. Einstein seeks candidates whose skills, and personal and professional experience, have prepared them to contribute to our commitment to diversity and excellence, and the communities we serve.

[Post Date: July 27, 2018]

Title: Postdoc UT Southwestern Medical Center

A postdoc position is available in my lab. I am looking for someone with experience in protein biochemistry and structural biology who is interested in studying the structure and mechanism of GPCRs. Project will involve elucidating mechanisms of activation and inhibition of therapeutically important CNS receptors, in collaboration with chemical biology collaborators. X-ray crystallography is a central technique in the lab, however we also use other biophysical techniques including cryo-EM and NMR.

Send CV to dan.rosenbaum@utsouthwestern.edu, or contact me for more information.

Daniel Rosenbaum,Associate Professor, Department of Biophysics, UT Southwestern Medical Center

[Post Date: July 27, 2018]

Title: Postdoc EMBL Interdisciplinary Postdocs
Website: https://www.embl.de/training/postdocs/08-eipod/index.html
Email: andrewmc@EMBL.FR

A three year postdoctoral position is available within the EIPOD (EMBL Interdisciplinary Postdocs) scheme to investigate how Slit mediates interactions with both DSCAM and Robo to regulate neuronal guidance using structural and biophysical approaches. Proteins will be produced in the Meijers lab at EMBL Hamburg using human embryonic kidney cells, and structural investigations will be done at the McCarthy lab at EMBL Grenoble. Complementary cell biology and light microscopy experiments will be done to verify the structure-derived hypotheses in the Schmucker lab at the VIB in Leuven and Ries lab at EMBL-Heidelberg respectively.

The ideal candidate has a background in protein purification and structure determination, with an interest in learning neurobiology and light microscopy techniques.

For more information on the EIPOD scheme, please visit:

A successful application requires a written motivation as to why this project is suitable and a research proposal. Candidates are therefore encouraged to contact Andrew McCarthy directly. The deadline for the application is 12th of September 2018.

[Post Date: July 26, 2018]

Title: Postdoc University of Oklahoma

The Duerfeldt Lab (http://www.duerfeldtlabs.com) in the Department of Chemistry & Biochemistry at the University of Oklahoma has an immediate opening for a highly-motivated postdoc trained in microbiology, molecular biology, and/or structural biology. The major research interest of the lab is to exploit bacterial enzyme/pathway activation as a strategy to diminish microbial fitness and/or pathogenicity. The ideal applicant should have an interest in determining the structure and function of specified proteins within pathogenic organisms to uncover the therapeutic potential of these targets. We are located on the same floor as the University of Oklahoma’s Structural Biology Center of Biomedical Research Excellence (COBRE) and as a COBRE affiliated lab, the Duerfeldt Group has prioritized access to all equipment, facilities, and expertise in the COBRE cores. More information about the cores can be found at the structuralbiology.ou.edu/. This represents a great opportunity for a postdoc trained in the aforementioned areas to contribute complementary expertise to the major research initiatives of the group, all while being immersed in a medicinal chemistry focused environment.

Start Date: as soon as possible

To apply, please send a CV, research summary, and contact information for 3 references to adam.duerfeldt@ou.edu. Only complete applications will be reviewed.

[Post Date: July 25, 2018]

Title: Postdoc University of Oxford
Website: https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_details_form.jobspec?p_id=136086

A postdoctoral position is available immediately in my group jointly with the lab of Maike Bublitz, in the Department of Biochemistry, Oxford. The aim of this BBSRC-funded post is to develop a novel methodology for membrane protein crystallisation that utilises NMR-derived information and very high magnetic fields. Candidates with experience in membrane protein crystallisation and/or NMR are particularly encouraged to apply. Due to limitations from the funder the post holder needs to start by December 1st.

Further information on this post, and instructions on how to apply, are available at the link above.

The application deadline is Aug. 31st and interviews of shortlisted candidates will be held shortly thereafter.

[Post Date: July 25, 2018]

Title: Postdoc University of Copenhagen
Website: https://tinyurl.com/y9wn5gvv

The UCPH Receptor Structural Biology Group (Kastrup group) and Computational Drug Design Group (Gloriam group), Department of Drug Design and Pharmacology, University of Copenhagen wish to employ a joint Post Doc in G protein-coupled receptor (GPCR) crystallography. The position starts 1. September 2018 or soon thereafter (latest Jan 1st) and lasts for 3 years.

Apply at the above link. E-mails will not be considered. Deadline August 15, 2018.

Professor Jette Sandholm Kastrup, UCPH (http://drug.ku.dk/research/biostructural_research/) has a strong track record of producing receptor crystal structures (~100 receptor structures deposited in the Protein Data Bank). She has a strong international network with leading medicinal chemists and pharmacologists.

The Gloriam group (www.gloriamgroup.org) conducts computational drug design, tightly integrated with leading chemists and pharmacologists, and structure-function studies of G protein-coupled receptors (GPCRs) – one of the largest drug target families. The group has in the last two years published in e.g. Nature, Cell, Nature Reviews in Drug Discovery, Nature Chemistry and Nucleic Acids Research.

This Post Doc fellowships is one of five that will take part in an ambitious interdisciplinary project spanning chemistry, pharmacology, structural biology, computational drug design and scientific database development. It is supported by the Novo Nordisk Foundation (Hallas-Møller Ascending Investigator) and headed by David Gloriam. The project focuses on GPCR biased signalling to illuminate the pathways to function and disease.

The overall objective of the project is to establish a joint public platform to consolidate the GPCR signalling field, and to identify novel mechanisms and ligands of biological and therapeutic relevance. The Post Doc within crystallography/cryo-EM will focus on (preferably biased) agonist complexes with the Free Fatty Acid 4 (FFA4) receptor, as well as other receptors for which structures are known but none with biased agonists. GPCR crystallisation requires comprehensive construct engineering to achieve optimal protein stability, expression in both insect and mammalian cells, homogeneity and crystal packing. The quality of the constructs will be evaluated based on the receptor yield and aggregate/monomer ratio (size-exclusion chromatography), as well as the thermostability (thermoshift assay). Crystallisation trials will benefit from our new state-of-the-art Crystal Gryphon LCP robot capable of efficiently screening numerous construct-condition combinations. Cryo-EM studies will take advantage of new state-of-the-art core facilities in Denmark.

Qualification requirements Mandatory requirements
• A PhD degree within structural biology
• Solid experience with expression and purification of membrane proteins
• Demonstrated ability to independently learn new concepts and solve biological problems
• Excellent communication skills: fluency in English and experience in writing scientific texts
Additional meriting qualifications Experience of, and skills in:
• G protein-coupled receptors
• Protein crystallography/cryo-EM
• Analysis of molecular structures and interactions
• Experience with crystallographic software packages
General job description Your key tasks as a Post Doctorial fellow at the Faculty are to:
• Manage and carry through your research project
• Write scientific articles
• Participate in the education and guidance of students
Additional requirements to be hired as an assistant professor
To be hired in the assistant professor the applicant should already have done a postdoc, supervised PhD students and have additional qualifications to document progression towards a competitive career (high-impact publications, own grants etc.). Employment as assistant professor includes teaching obligations and the possibility to upgrade pedagogical qualifications.

Key criteria for the assessment of applicants
• Professional qualifications relevant to the project
• Relevant work experience
• Publications
• Other professional activities
• Language skills
• Good interpersonal skills
Terms of employment
The post will be filled according to the Agreement between the Danish Ministry of Finance and the Danish Confederation of Professional Associations. The post is covered by the Protocol on Job Structure.

For further information about the post, please contact Professor Jette Sandholm Kastrup via jsk@sund.ku.dk or David Gloriam via david.gloriam@sund.ku.dk.

The application, in English, must be submitted in the online application form. The application must include the following appendices: Appendix 1: curriculum vitae with documentation of education. Appendix 2: a complete list of publications. Appendix 3: documentation of additional research qualifications, incl. letter of recommendations.

In addition to the material the applicant wishes to be included in the assessment, the Assessment Committee may include further material in their assessment of the applicant, such as reference letters. In such circumstances, it is the responsibility of the applicant, on request, to send the material to the Committee. No research/project plan needs to be submitted. Following processing of the application, any application material sent will be destroyed. The applicant will be assessed according to the Ministry of Science Technology and Innovation Executive Order no 284 of 25. April 2008.

University of Copenhagen and Denmark
Founded in 1479, the University of Copenhagen is the oldest university in Denmark. With 39,000 students and 10,000 employees, it is among the largest universities in Scandinavia and one of the highest ranking in Europe. The University consists of six faculties, which cover Health and Medical Sciences, Humanities, Law, Science, Social Sciences and Theology. Read more at www.sund.ku.dk and www.drug.ku.dk.

Copenhagen is a modern capital with plenty of opportunities in culture, design, architecture, restaurants and a diverse nightlife. At the same time, the city offers beaches, beautiful parks and green nature areas, and the Copenhageners bike everywhere. The Danish society prioritises a good work-life balance, and the work culture is well adjusted for families with children. Read more at http://ism.ku.dk/.

Employer: University of Copenhagen University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.
Part of the International Alliance of Research Universities (IARU), and among Europe’s top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.

[Post Date: July 24, 2018]

Title: Postdoc Vanderbilt University


Vanderbilt University, Nashville, TN

The Jackson Lab is seeking a motivated and enthusiastic postdoc to join our team to work on structures and functions of coat complexes in membrane trafficking, autophagy, and human disease. We employ a range of techniques in biochemistry, biophysics, structural biology, and cell biology to investigate cargo recognition, assembly, and regulation of coats. We aim to understand both the fundamental cell biology of how coats mediate trafficking events, as well as the molecular bases for neurological diseases associated with mutated coats.

This position may suit a cell biologist seeking to learn modern structural methods (X-ray crystallography, single particle cryoEM) or a biochemist/structural biologist wanting to extend his/her repertoire to include cell biology. Experience in molecular cloning, protein expression, and protein purification from E. coli is preferred. Previous structural or tissue culture experience is not required but may be advantageous; cryoEM experience would be very advantageous.

You must hold a Ph.D. (or equivalent) in biochemistry, structural biology, cell biology, or a related discipline and demonstrate a track record in conducting high quality original research. Please send a CV, cover letter, and three letters of recommendation to Lauren (lauren.p.jackson@vanderbilt.edu). We will consider candidates until the position is filled. The tentative start date is Sept 1, 2018.

The Jackson lab is Funded by NIH and the Pew Charitable Trusts, and the lab is affiliated with the Vanderbilt Center for Structural Biology, Vanderbilt Brain Institute, and Epithelial Biology Center. We are located in Nashville, TN, a vibrant city with fantastic neighborhoods, restaurants, cafés, music, parks, and outdoor activities. For current and previous work, check out our website at www.jackson-lab.com or contact Lauren directly.

[Post Date: July 23, 2018]

Title: Postdoc Hebrew Univ of Jerusalem

The Shifman lab [http://www.bio.huji.ac.il/Shifman] in the Hebrew University of Jerusalem is looking for a postdoctoral scholar in Experimental Protein Engineering. In out lab, we engineer inhibitors of protein-protein interactions starting from natural binding partners as well as from unrelated small protein domains. Such inhibitors could be evolved to selectively target only one family member among hundreds of homologs, making them attractive drug candidates. Using a combination of computational and directed evolution approaches, we convert the natural low-affinity binding partners into high-affinity and high-specificity binders. In the particular project, we would like to engineer specific inhibitors to various types of Matrix Metalloproteinases, enzymes whose activity is related to various diseases including cancer. These molecules will be later transformed into drug candidates. We are looking for a highly motivated person with a background in Biophysics or Biochemistry to take over this exciting project. The candidate should have experience with molecular biology and protein expression/purification. Experience in yeast surface display is a plus. Our lab is located in the Department of Biological Chemistry in the Hebrew University of Jerusalem, Jerusalem, Israel. Please contact Julia Shifman: jshifman@mail.huji.ac.il

[Post Date: July 23, 2018]

Title: Research Associate Imperial College London

Reference: MED00316

Job Title: Research Associate

Section/Division/Department: Structural Biology / Experimental Medicine / Medicine

Salary: £36,800 per annum

Campus: South Kensington
We wish to recruit two Research Associates to work in the research group of Professor Dale Wigley (http://www.imperial.ac.uk/people/d.wigley), in the Section of Structural Biology, Department of Medicine, at Imperial College London’s South Kensington Campus. The successful candidates will join a multi-disciplinary team of international researchers investigating the structures and mechanisms of chromatin modifying complexes in human DNA damage repair and cancer. We combine structural biology techniques with biochemistry to understand molecular mechanisms for DNA repair that prevent cancer in humans. The successful candidates will have proven expertise in either or both of these areas.

You must hold a PhD, or equivalent, in biochemistry, enzymology or structural biology and have a demonstrated track record in conducting high quality original research. Knowledge at postgraduate level in structural biology (crystallography or electron microscopy) and/or biochemistry is essential and experience in expression/purification of multi-protein complexes in insect or human cells is desirable.

The positions are full-time, fixed-term posts for four years.

Closing date: 19 August 2018

Should you have any queries please contact:
Professor Dale Wigley – d.wigley@imperial.ac.uk

Should you have any queries regarding the application process, please contact:
Moe John – m.john@imperial.ac.uk

[Post Date: July 23, 2018]

Title: Protein Expression & Purification Scientist
Website: https://sjobs.brassring.com/TGWebHost/jobdetails.aspx?partnerid=25119&siteid=5134&areq=10715BR

There is an opportunity to join the Protein Biochemistry team at Vertex Pharmaceuticals based in the UK as a Research Scientist (Protein expression and purification). Please see the advert in the link above. Interested candidates should apply directly through our website. Applicants must be eligible to work in UK. The position is for a 12 month fixed term contract.

[Post Date: July 23, 2018]

Title: Postdoc Scientist Protein Production for Dementia
Website: https://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/135677-Postdoctoral-Scientist-Protein-Production-for-Dementia

There is an open position at the Oxford Drug Discovery Institute for a postdoctoral scientist in protein production for dementia target validation (Vacancy ID 135677).
Applications should be done through the website link above.

[Post Date: July 23, 2018]

Title: Associate Director Structural Biology
Website: https://rheosrx.com/our-workplace/careers/associate-director-structural-biology/

Title: Associate Director, Structural Biology
Department: Drug Discovery
Reports To: VP, Drug Discovery
Location: Cambridge, MA

The Company:
At Rheos, we are leading the way in the emerging field of immunometabolism to discover novel medicines to treat inflammatory-mediated diseases, including autoimmune diseases. Our medicines control metabolic pathways of immune cells that influence their activation state, in order to rebalance immune responses that cause inflammation or autoimmunity.

The Role:
The Associate Director, Structural Biology, will provide leadership and expertise in the structural characterization of Rheos’s drug targets. The ideal candidate will be focused on protein crystallography but will integrate with the drug discovery organization to implement a variety of biophysical techniques.

Major Responsibilities:
• Collaborate with colleagues in lead discovery, biology, and chemistry to develop a structural biology strategy.
• Designing biophysics-grade protein constructs and assisting in the optimization of purification protocols.
• Crystallization, X-ray structure determination, and analysis of important drug targets through working with external collaborators.
• Management of external structural biology collaborations (CROs)
• Providing regular updates to cross-functional teams and helping guide structure-based compound design in close collaboration with chemistry group.

Requirements and Qualifications:
• PhD degree structural biology or biophysics
Required Experience:
• 7+ years of drug discovery experience in a pharmaceutical/biotechnology setting;
• Demonstrated ability to solve difficult problems in protein crystallography, structural biology and biophysics
• Demonstrated competency in protein construct design and expression and purification strategies using bacterial, insect, and mammalian hosts.
Knowledge, Skills & Abilities:
• Strong knowledge of the drug discovery process, with deep experience in implementing hit identification strategies through candidate selection;
• Extensive knowledge of protein structure and function, with the ability to articulately communicate structural information to a broad audience.
• Experience with other structural techniques (e.g. electron microscopy, small-angle X-ray scattering) is preferred.

If this excites you, please submit your CV with the title of the position in the subject line to careers@rheosrx.com

[Post Date: July 19, 2018]

Title: Postdoc Biozentrum der Universität Würzburg

A PhD and a postdoc position in structural biology is available at the department of biochemistry at the Biocentre (head Prof. Utz Fischer) of the Julius Maximilians University, Wuerzburg/Germany in the field of RNP biochemistry.

The successful applicant will establish protocols for the isolation and reconstitution of preparative amounts of RNP complexes, which will then be characterized by cryo-electron microscopy and x-ray crystallography. We are looking for candidates with expertise in protein expression and purification and a strong interest in structural biochemistry. Prior knowledge of cryo electron microscopy, protein crystallography or biophysical methods is a plus.

Please send your application including a letter of interest, curriculum vitae, academic certificates and the name and contact detail of at least one referee to

Prof. Utz Fischer/Dr. Clemens Grimm
e-mail: Clemens.Grimm@biozentrum.uni-wuerzburg.de
Lehrstuhl für Biochemie
Biozentrum der Universitaet Wuerzburg
Am Hubland
D-97074 Wuerzburg

[Post Date: July 19, 2018]

Title: Research Associate Structural Biology
Website: http://files8.design-editor.com/93/9333026/UploadedFiles/7CF5EF39-B19A-4DFA-6C1C-D30A3642FD8B.pdf

There is an opportunity to join the Structural Biology team at Confo Therapeutics based in Ghent (Belgium) as Research Associate. Please see the advert in the link above. Interested candidates should apply forwarding a short motivation letter and CV to careers@confotherapeutics.com.

[Post Date: July 19, 2018]

Title: Postdoc Texas Tech University HSC

A new position is open for a membrane protein crystallographer at a postdoctoral research associate level in Guan Lab at Department of Cell Physiology and Molecular Biophysics of Texas Tech University Health Sciences Center, TX, to perform NIH-funded research projects, which involve a comprehensive structural/functional investigation of bacterial/human nutrient transporters using X-ray crystallography and other biophysical techniques.

The laboratory seeks a motivated individual with strong knowledge and expertise in protein X-ray crystallography. Experience in membrane protein biochemistry and solute transport is highly favored. Salary is competitive based on experience. For more details see:

Interested applicants should submit their CV and contact information for three references along with a cover letter through our website (http://www.texastech.edu/careers/staff-positions.php) with the requisition ID of 14651BR.

[Post Date: July 17, 2018]
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