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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.

Title: Postdoc Charles Sturt University
Website: http://csusap.csu.edu.au/~jforwood/#

We have a two year postdoctoral position in Australia. The start date can be anytime from now. The work will involve protein expression, purification, crystallisation, and structure determination of protein-protein complexes. For specific details on the project and/or work environment, please email jforwood@csu.edu.au

[Post Date: October 22, 2018]

Title: Postdoc University of Delaware
Website: http://xtalsmgddp.wixsite.com/parasharlaboratory

Parashar laboratory at University of Delaware College of Health Sciences, is currently seeking a Postdoctoral Fellow to perform structure-function studies of proteins regulating bacterial signaling.

• Ph.D. in Biochemistry, Molecular Biology, Structural Biology, or a related field
• Experience with cloning, protein expression, and protein purification methods
• A sound understanding of methods and approaches relating to macromolecular crystallography and/or single particle Cryo-EM preferred.
• Ability to plan and carry out research projects independently
• Ability to work on own initiative and take personal responsibility for delivery of work
• Excellent problem solving, interpersonal, communication and presentation skills
• A working knowledge of bacterial genetics and computational modeling of protein-ligand interactions preferred

Responsibilities include:
• Performing experiments for cloning, protein expression, and purification of proteins for biochemical and structural studies; robotic screens for crystallization; optimizing crystallization conditions; and collecting and analyzing diffraction data.
• Performing model building and structure refinement.
• Maintaining laboratory equipment to meet unique needs of the research activity
• Assisting with preparation of grant proposals, presentations and publications
• Actively seeking new collaborative projects within the department and externally

University of Delaware is well equipped with state-of-the-art equipment for molecular biology, protein purification, and crystallography, including crystallization robot, crystal imaging system, and X-ray generator. Please visit Parashar Laboratory website for more information. The laboratory plans to start using Cryo-EM for structural elucidation. For consideration, please send your CV, list of three references and other relevant information to parashar@udel.edu with subject line "postdoctoral application".

[Post Date: October 21, 2018]

Title: Technical Assistant
Website: https://stellen.uni-konstanz.de/jobposting/969fc6c37f577d1bbd9640926c79bcc7d86879a8

Part-time opening for a technical assistant in our laboratory at the University of Konstanz. The position might be of interest to candidates in our geographical area. Please kindly bring it to the attention of suitable applicants in your lab. Please see the full details at the link.

[Post Date: October 19, 2018]

Title: Scientist Macromolecular Crystallographer

The New York Structural Biology Center (NYSBC) is a shared research organization, owned and operated by nine eminent research universities and medical schools in the New York area. NYSBC is devoted to advancing structural and functional characterization of biological processes through technology development for cutting-edge biomedical research. X-ray crystallography is a crucial component of NYSBC activity, and the NYX Microdiffraction Beamline has been developed by NYSBC at the National Synchrotron Light Source II (NSLS-II) to support this work.

NYSBC seeks a Scientist to join the NYX beamline team for NSLS-II sector 19-ID at Brookhaven National Laboratory (BNL) to help steer further development of macromolecular crystallography at NYX. The new scientist will be employed by NYSBC organization and stationed at its NYX beamline at NSLS-II. The successful candidate will establish relevant research projects in collaboration with NYSBC scientists, groups at its constituent institutions, or with BNL structural biologists and other groups. These projects will exploit the unique qualities of the NYX beamline and can be coordinated with the NSLS-II life science programs. Responsibilities will include interacting with the scientific user community and assisting visiting scientists with their data collections and structure solving to further the scientific mission of NYX. In addition, the new scientists will advance the beamline’s technical capabilities by initiating or conceiving upgrades of its hardware and software for the benefit of the structural biology community at NYSBC and beyond.

Salary level will be commensurate with qualifications and experience.

Required Knowledge, Skills and Abilities:
• Ph.D. or equivalent in biophysics, biochemistry, chemistry, or related field
• At least three years of prior experience in data acquisition and analysis for structure determination by macromolecular crystallography (MX)
• Strong publication record in diffraction analysis
• Excellent written and oral communications skills
• The ability to interact effectively in a team environment with a diverse group of scientists, engineers, technical staff, and users

Preferred Knowledge, Skills, and Abilities:
• Prior experience in the use of synchrotron beamlines for structural biology
• Five or more years of prior experience in MX data acquisition, analysis, and structure determination
• Experience with X-ray optics, X-ray detectors, and/or software for crystallographic computing
• Demonstrated success in leading scientific or technical groups or projects.

Direct inquiries and applications, including cover letter and CV, to Dieter Schneider (schneider@bnl.gov), Lead Beamline Scientist for NYX, or to Wayne Hendrickson (wah2@cumc.columbia.edu), Scientific Director, NYSBC.

[Post Date: October 18, 2018]

Title: Postdoc UT Southwestern Medical Center

A postdoctoral position in structural biology is available in the Center for the Genetics of Host Defense at UT Southwestern Medical Center at Dallas. Using forward genetics, the lab identifies many novel proteins and protein complexes that function in the immune system, metabolism, and the nervous system. Many of these proteins and protein complexes are involved in diseases including immune deficiency, autoimmunity, inflammatory bowel disease, and diabetes. We are interested in using structural biology to develop molecular mechanisms that describe how these proteins and protein complexes function in the context of live cells and mice. UTSW-Medical Center is well equipped with state of the art instrumentation for protein biochemistry, biophysics and structural biology. This includes monthly access the Advanced Photo Source synchrotron beamline, in-house robotic systems for screening and optimizing crystals, various high strength NMR magnets equipped for solution state and solid state NMR, and brand new cryo-electron microscopes supported by the Cryo-Electron Microscopy Facility at UTSW-Medical Center. New Ph.D. graduates are highly encouraged to apply. Please visit the lab website at http://beutlerlab.org/ for more information.

Successful candidates are expected to be highly motivated and well trained in protein biochemistry, or in structural biology using NMR, X-ray crystallography or cryoEM. Please send the following to Betsy Layton at Betsy.Layton@utsouthwestern.edu, with the subject line NEW Postdoctoral Application in Structural Biology:

1) A cover letter explaining your current research interests with a description of why you are interested in the Beutler laboratory.

2) A complete CV with links to all of your publications.

3) A list of three references, with their current work address, title, email address, and phone number.

[Post Date: October 18, 2018]

Title: Postdoc University of Pennsylvania School of Med

The Yi-Wei Chang lab in the University of Pennsylvania School of Medicine is looking for an enthusiastic postdoc to join the group. Our main research interests are (1) in vivo structural study of important biological processes/nanomachines through electron cryo-tomography; and (2) development of correlative light and electron microscopy methods and further their applications. (Our lab website)

The successful candidate is expected to have a strong background in cryo-EM, X-ray crystallography, super-resolution microscopy, physics, or computer programming, and, most importantly, is inspired by the importance and FUN of in situ structural determination.

Our institute is fully equipped for cutting-edge electron cryo-tomography: a 300keV Titan Krios G3i cryo-EM with Volta phase plate, Quantum energy filter and K3 direct detector, a cryo-FIB-SEM, a cryogenic fluorescence light microscope, a comprehensive sample preparation and screening facility (EMRL), and several state-of-the-art computer clusters for data processing.

If you are interested in joining us and having a lot of fun together while building up a strong publication record, please send your CV and a cover letter to me directly at (yi-wei.chang@pennmedicine.upenn.edu). Please also feel free to contact with me if you have any questions regarding this position. Thanks!

[Post Date: October 16, 2018]

Title: Research Institute Manager Post
Website: https://jobs.le.ac.uk/vacancies/vacancy-details.aspx?VacancyID=332

The Leicester Institute of Structural and Chemical Biology (LISCB) is one of five flagship research institutes recently established by the University of Leicester. LISCB hosts 22 active research groups and brings together internationally renowned research using structural biology, chemical biology and single molecule methods to investigate major challenges in fundamental biological processes into a single world-leading unit.

Since it was established in August 2016, LISCB has received significant investment from the University and more than £12million in external funding. This includes a major investment in a state-of-the-art cryo-electron microscopy facility and significant upgrades to the NMR facility.

We are looking to recruit a Research Institute Manager to further develop the scientific direction and impact of the LISCB, working closely with the Institute Director and other senior staff. The successful candidate will develop and maintain the strategic scientific vision of the Institute and establish the Institute’s long-term sustainability. They will also engage in events and activities to promote the LISCB’s national and international profile and reputation.

Please go to https://jobs.le.ac.uk/vacancies/vacancy-details.aspx?VacancyID=332 for more information and to apply.

[Post Date: October 16, 2018]

Title: Postdoc Cornell University
Website: https://mbg.cornell.edu/people/ailong-ke/

A NIH-funded postdoctoral position in structural biology is open in Prof. Ailong Ke’s laboratory at Cornell University, Ithaca, NY, USA. The research projects seek to understand the structure and function of RNA-protein complexes in CRISPR-Cas and other RNA-guided systems. For representative publications, please refer to: Science. 2018 Jul 6;361(6397); Nature. 2017 Oct 5;550(7674):137-141; Cell. 2017 Jun 29;170(1):48-60; Nature. 2016 Feb 25;530(7591):499-503.

Applicants are expected to hold (or expect) a Ph.D. or equivalent degree in structural biology (crystallography or EM). Prior experiences in nucleic acid biochemistry and/or single molecule techniques are appreciated. Additional information can be found at http://sites.google.com/site/kelaboratory/

To apply, please send CV and names of 3 references to: ak425@cornell.edu

Cornell University is an equal opportunity, affirmative action educator and employer.

[Post Date: October 09, 2018]

Title: Postdoc Albert Einstein College of Medicine

A Postdoctoral Position in Structural Biology, Enzymology and Drug Development

A position for a NIH-funded postdoctoral fellow is available immediately in the Syun-Ru Yeh Laboratory at Albert Einstein College of Medicine. The postdoctoral fellow will take a lead in (1) elucidating structure and function relationships of two immunotherapeutic drug targets, human indoleamine 2,3-dioxygenase and tryptophan dioxygenase, and (2) developing inhibitors targeting the enzymes as therapeutic strategies for cancer treatment. The postdoctoral fellow will join an exciting program with a focus on enzymology, spectroscopy-guided crystallography and inhibitor development.

The successful applicant must have demonstrated experience in chemistry, biochemistry, biophysics or closely related field. Expertise in x-ray crystallography, spectroscopy and/or computational modeling is a plus. Applicants should provide a CV and a cover letter justifying their suitability and interest in the position. Applicants should also arrange to have three letters of reference sent to Dr. Syun-Ru Yeh (syun-ru.yeh@einstein.yu.edu).

Albert Einstein College of Medicine is located in New York in a scenic Bronx campus that includes comfortable, affordable housing in an area rich with recreation and entertainment. The scientific environment provides outstanding research training opportunities.

[Post Date: October 09, 2018]

Title: Postdoc Uniforned Services University

A postdoctoral position is available immediately to participate in an inter-disciplinary research program on structural immunology at the Uniformed Services University of the Health Sciences (USU) in Bethesda, MD.

Candidates are expected to work on ongoing research projects in structural biology aimed at understanding molecular basis of action of antibodies to HIV-1 with the ultimate goal of development of new protein-based therapeutics and novel vaccine concepts. Qualifications for the position include: strong research interest and experience in molecular cloning, protein expression, molecular interaction analyses, protein chemistry, and biophysical and structural techniques that should include X-ray crystallography or/and cryo-electron microscopy. A background in immunology will be considered a strong plus. Candidates need to be highly motivated individuals who enjoy working as part of a young, dynamic, collaborative and multidisciplinary team. Qualified candidates should have a doctorate in in the field of Structural Biology, Biochemistry, Bioinformatics or Immunology. New Ph.D. graduates are highly encouraged to apply.

USU is in Bethesda, MD, directly across the street from the NIH, and is thus part of an extraordinarily vibrant local biomedical research community. Our research projects take advantage of excellent USU Core facilities that include Structural Biology and Imaging Core equipped with X-ray diffraction system for home data collection transmission electron and ultramicrotome microscopes. USU has a strongly collaborative environment, with weekly Immunology data club and journal club meetings, as well as regular research seminars featuring local and invited speakers.

Candidates should apply directly to Dr. Marzena Pazgier, Marzena.Pazgier@usuhs.edu submitting a CV plus names and contact information for 3 references. Preference will be given to candidates with, strong experimental skills, a strong record of peer-reviewed publications, excellent communication and writing skills.

[Post Date: October 09, 2018]

Title: Postdoc Washington State University St Louis

Postdoctoral positions in membrane protein biochemistry and structural biology are available in the laboratory of Peng Yuan at Washington University School of Medicine in St Louis, Missouri. The lab is interested in understanding molecular mechanisms and physiological functions of membrane transport proteins that play important roles in human health and disease (for most recent examples: Nature Structural & Molecular Biology 2018, doi: 10.1038/s41594-018-0037-5; Nature Microbiology 2018, doi: 10.1038/s41564-018-0255-y). We use a combination of approaches including X-ray crystallography, single-particle cryo-electron microscopy (cryoEM), biochemical reconstitution and electrophysiology. The lab is well equipped with state-of-the-art setup for membrane protein biochemistry, biophysics and structural biology. In addition, we have excellent access to synchrotron X-ray facilities including the Advanced Photon Source and state-of-the-art Titan Krios cryo-electron microscope at the Washington University Center for Cellular Imaging.

Successful candidates are expected to be highly motivated and well trained in membrane protein biochemistry, or in structural biology using X-ray crystallography or cryoEM. Please send your application including cover letter, CV, and contact information for three references to yuanp@wustl.edu.

[Post Date: October 09, 2018]

Title: Senior Scientist Evotec
Website: https://recruitment.evotec.com/VacancyDetails.aspx?FromSearch=True&MenuID=QSAukis1tlc=&VacancyID=738

Evotec is a leader in the discovery and development of novel small molecule drugs with operational sites in Europe and the US. The Company has built substantial drug discovery expertise and an industrialised platform that can drive new innovative small molecule compounds into the clinic. In addition, Evotec has built a deep internal knowledge base in the treatment of diseases related to anti-infective, neuroscience, pain, oncology, inflammation and metabolic diseases. Leveraging these skills and expertise the Company intends to develop best-in-class differentiated therapeutics and deliver superior science-driven discovery alliances with pharmaceutical and biotechnology companies.

We are looking for highly motivated individuals for our Abingdon site to work as a Senior Scientist, Structural Biology, X-Ray Crystallography (2 x 12-month temporary contract)

Evotec (UK) Ltd is currently seeking to add to our Structural Biology Department. The group works closely with our Discovery Chemistry Department and with clients to develop novel small molecule drugs. The group is at the forefront of new science and technology, and is seeking to expand as business needs grow. Our site is located less than 4 miles from Diamond Light Source and eBIC national facilities for access to synchrotron radiation and Cryo Electron Microscopy respectively to support our high-end analysis of samples.

The position is initially temporary, for 12 months duration, but may become permanent dependant on business need.

Required Knowledge, Skills and Abilities:
• Expertise in X-ray crystallography from crystal preparation and handling, data collection through to analysis of structures
• Experience in gene design and protein purification
• Self-motivated, enthusiastic, cooperative and reliable
• Knowledge of basic laboratory techniques, and understanding of the science underlying the techniques and experiments
• Experience of working in a laboratory environment
• The ability to adapt to changing demands whilst operating under pressure to deadlines
• The ability to work accurately and with attention to detail
• Good interpersonal skills and the ability to work well with other scientific staff
• The ability to work well independently, and as part of a team
• Good organisational and time management skills
• Good verbal communication skills
• Ability to maintain excellent laboratory records
• Computer proficiency

Responsibilities may include:
• Supporting a project team by conducting experiments with defined, agreed objectives and timelines
• Contributing to the design, execution and interpretation of experiments in a project team to accomplish project goals
• Adapting scientific knowledge to resolve problems encountered in achieving defined goals with assistance from line manager or other team members to meet internal and project deadlines
• Preparing reports of findings, presenting data, and collaborating with other scientists at Evotec
• Presenting own work at project technical meetings, and department technical meetings when required
• Demonstrating full command of all techniques and tools required for assigned responsibilities within the given project
• Ensuring safe working practices of themselves and any direct reports
• Complying fully with the company safety policy (including COPs and SOPs) when performing experiments
• Reading scientific literature relevant to the project
• Adhering to Lab Notebook guidelines regarding accurate documentation of lab experiments

Desirable Knowledge, Skills and Abilities:
• Membrane protein expertise
• Cryo-Electron Microscopy sample preparation and data analysis
• Fragment based drug discovery

Education and Experience:
• PhD in Structural Biology, Biochemistry or related area

[Post Date: October 05, 2018]

Title: 2019 Summer Intern Merck
Website: https://merck.taleo.net/careersection/jobdetail.ftl?job=ADM009828

The Department of Biochemical Engineering and Structure within Merck Research Laboratories located in Kenilworth, NJ, is seeking a summer intern. The intern will function as a fully-integrated member of a structural biology team, consisting of X-ray crystallographers, protein biochemists, and molecular biologists.

The job will involve the crystallization of monoclonal antibodies for drug delivery and purification. The intern will apply various purification methods to generate proteins suitable for crystallization. Day-to-day research will focus on using techniques in protein biochemistry and biophysics to formulate and characterize these samples in preparation for crystallization experiments. The intern will be responsible for accurate electronic notebook recording, safe laboratory practices, and presentation of data and their interpretation to a team of scientists. The intern will also attend departmental and team meetings to gain a wider perspective on the drug development process in the pharmaceutical industry.

We are seeking intern candidates with strong academic performance, communication skills, teamwork, and the ability to work in a cross-functional environment.

This is a full- time internship position. Housing subsidy is not available as part of this program and must be funded 100% by the student.

[Post Date: October 05, 2018]

Title: Postdocs Institut Pasteur in Paris, France
Website: https://research.pasteur.fr/en/job/2-postdoctoral-positions/

Two positions are available in the laboratory of Pierre-Jean Corringer at the Institut Pasteur in Paris, France

Our laboratory is looking for two highly motivated post-doctoral fellows with strong background and experience in structural biology/biophysics/ion channel structure and function. Our lab studies the structure and function of pentameric ligand-gated ion channels, with a particular emphasis on understanding the structural bases of ion channel gating and regulation by small molecules. All projects in the lab are interdisciplinary in nature and combine structural techniques with functional approaches, and the two proposed positions concern: 1/ voltage-clamp fluorometry, to monitor the ion channel gating by electrophysiology concomitant with protein motions by fluorescence in physiological conditions and 2/ the structural biology of ion channels in complex with small ligands, using both X-ray crystallography and cryo-electron microscopy (cryo-EM). Both projects also involve molecular biology, protein biochemistry and kinetic modeling. Our lab is fully equipped for molecular biology, biochemistry and voltage-clamp fluorometry and has access to the renowned platforms of X-ray crystallography and cryo-EM (with a recently installed Titan Krios microscope) of the Institut Pasteur in Paris. The Institut Pasteur offers a highly dynamic social and scientific environment in the heart of Paris.

The successful candidate must have a PhD (or being in the process of completing one) in a relevant field with a demonstrated track record of productive research, and must be able to work both independently and as part of collaborative team. For the voltage-clamp fluorometry project, previous experience in fluorescence techniques and/or electrophysiology is highly desirable. For the structural biology project, previous experience in cryo-EM is highly desirable, as well as experience in protein production in human cell lines and X-ray crystallography.
One position opens in January 2019, the other opening around July 2019. Post-doc will be funded through an ERC advanced grant for up to five years.

Applications including a cover letter, CV, and the email addresses of two references should be sent to:

Pierre-Jean Corringer, pjcorrin@pasteur.fr Channel-Receptors Unit Neuroscience Department Institut Pasteur, Paris

[Post Date: October 05, 2018]

Title: Postdoc CIC bioGUNE
Website: https://www.cicbiogune.es/job-offers-form

A position for a postdoctoral researcher is available in the Membrane Trafficking Lab lead by Dr Aitor Hierro at the CIC bioGUNE (Bilbao, Spain). The research programme aims at studying the supramolecular organization and function of endosomal coat complexes using a combination of X-ray crystallography, cryo-electron microscopy and cryo-electron tomography.

Applicants must hold a PhD in Biochemistry, Biophysics, Structural Biology or a related field. The ideal candidate should have experience in cryo-EM/TM and image processing with a demonstrated record of accomplishments.

The Structural Unit at CIC bioGUNE is very well equipped for the structural work holding access to X-ray crystallography, NMR and EM local facilities as well as regular access to synchrotron and world-class cryo-EM/TM platforms.

Candidates should submit their CV, a cover letter and the name and contact details of, at least, 2 references using the following link (https://www.cicbiogune.es/job-offers-form) and indicating 43131 as reference.

Closing date: 5th November 2018

If you have any questions, please contact Dr Aitor Hierro: ahierro@cicbiogune.es

[Post Date: October 03, 2018]

Title: Postdoc University of Leicester

Vacancy Name: Postdoctoral Research Associate
Vacancy ID: 474
Vacancy Department: Leicester Institute of Structural and Chemical Biology/Molecular and Cell Biology
Advertising Start Date: 28/09/2018 00:00:00
Advertised Salary: Grade 7 £34,189 to £39,609 per annum

We wish to recruit a Postdoctoral Researcher to the group of Prof Peter Moody to take a leading role in a programme of research to investigate the mechanism of heme peroxidases, using advanced and innovative structural and spectroscopic methods. Our work is summarised in Moody & Raven (2018) Acc.Chem. Res. 51 (2), pp 427–435 DOI: 10.1021/acs.accounts.7b00463, and in more detail in the papers listed on Peter Moody’s Departmental home page https://www2.le.ac.uk/departments/molcellbiol/staff/moody

The research is funded by the BBSRC and is a collaboration with Professor Emma Raven of the Chemistry Department at Bristol University (http://www.bris.ac.uk/chemistry/people/emma-raven/index.html) and will involve expressing and purifying proteins from recombinant sources, gaining structural and mechanistic insights using X-ray (using home and synchrotron sources) and Neutron crystallography (using ILL Grenoble, FRM-II Munich and ONRL, USA). We have recently conducted experiments using the Free Electron Laser SACLA in Japan and hope to use other FEL sources such as EuXFEL soon. Leicester has recently acquired state of the art cryo-electron microscopes and we would like to explore the potential for micro electron diffraction. A wide range of biochemical and biophysical techniques (especially spectroscopy) will be used to explore enzyme intermediates.

You will develop your own original research projects, in line with the aims and objectives of the research programme and assist with the supervision of graduate and undergraduate students. You will write up your research findings for dissemination amongst the research team and the broader international community and make presentations at scientific meetings in the UK and overseas.

About you
The successful applicant should hold a PhD, have a strong background in biochemical or structural analysis of proteins and have a keen interest in experimental design and determining the direction of the research programme.

Additional information
LISCB comprises over 20 research groups drawn from several departments, including the Department of Molecular and Cell Biology, and brings together internationally renowned research using structural biology, chemical biology and single molecule methods to investigate major challenges in fundamental biological processes into a single world-leading unit.

The University of Leicester is committed to international excellence, world-changing research and high quality, inspirational teaching. Recently, the MRC in partnership with the Universities of Leicester, Warwick, Nottingham and Birmingham has invested into a state-of-the-art CryoEM facility at the Leicester Institute for Structural and Chemical Biology (LISCB), one of four new, flagship Research Institutes of the University of Leicester. We are strongly committed to inclusivity, promoting equality and celebrating diversity among our staff and students. You will develop your career in a supportive and collaborative academic environment in one of the world’s leading research-intensive universities; elite in the excellence of our research, yet distinctive for the genuine synergy between our research and teaching.

In return for your hard work, we offer a working environment that is committed to inclusivity, through promoting equality and valuing diversity. We offer a salary package with excellent pension scheme, a generous annual leave allowance and an online portal that offers a range of lifestyle benefits and discounts. Located close to Leicester city centre, our award winning campus benefits from a wide range of cafes, a fully equipped sports centre and nursery facilities. Further information regarding our extensive range of staff benefits is available here.

Informal enquiries and are welcome and should be made to Professor Peter Moody on Tel: +44 (0)116 229 7097 or email: peter.moody@leicester.ac.uk

[Post Date: September 28, 2018]

Title: Associate Research Scientists Bristol-Myers Squibb

Bristol-Myers Squibb has two open positions for Associate Research Scientists, Protein Crystallization

The only way to apply for these positions are at the following URLs:



[If you have questions, please contact Shannon.Keefe@bms.com, Talent Acquisition Specialist, R&D]

Job description

Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. Driven to make a difference, from innovative research to hands-on community support. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Responsibilities Required

As a key member of the Molecular Structure & Design group, the successful candidate will be responsible for crystallization, purification and characterization of recombinant proteins utilizing knowledge of conventional and affinity chromatography methods, gel electrophoresis, crystallization, and general laboratory procedures. As a member of a team involved in the early stages of discovery, the position requires close collaboration with molecular biologists, protein scientists and structural biologists as well as scientists working in the various disease biology and translational areas within preclinical research. The candidate must be self motivated, possess excellent communication skills, and work both independently as well as in teams. Personal attributes of integrity and scientific creativity are required.

Major Skills Required
• BS/MS in Biochemistry, Structural Biology or related field plus 2-6 years of experience of industry or academia
• Carry out protein crystallization experiments, crystallization optimization, crystal harvesting for proteins and protein ligand complexes.
• Utilize crystallization automation equipment (liquid handlers, drop setters, imagers, etc.)
• Carry out protein purification / characterization as well as a thorough understanding of protein chromatography principles.
• Capable of independently designing experiments, generating data and interpreting results; demonstrated ability to work in a team environment.
• Possesses strong communication skills - be a good listener, have strong, concise, and consistent written and oral communication skills.
• The following skills, while not required, would be a plus
•Ability to independently troubleshoot purification systems and protocols.
•Experience in E. coli fermentation and protein expression.
•Experience in X-ray data collection and knowledge of X-ray structure analysis is a plus.

[Post Date: September 28, 2018]

Title: Group Leader Viva Biotech

Viva Biotech, located in Shanghai, China, is specialized in structure-based drug discovery providing preclinical drug discovery research services to global pharmaceutical and biotech companies. We have opening for program leader in structural biology and biochemistry. Anyone who is interested in the position please send CV to jin.gao@vivabiotech.com.

Job title: Group Leader in Structural Biology or Biochemistry

Job description

We are seeking a highly motivated individual with experience in protein biochemistry and structural biology. Candidates will lead the structural biology team to carry out the biochemistry studies and/or gene-to-structure studies which elucidate the interactions between small molecules/peptides and their targets. Experiences with protein expression and purification, excellent interpersonal and managerial skills, team player with excellent written and verbal communication skills and proficiency in structure biology related software. Excellent communication skill in English; 3-5 years working experiences with in US or Europe.


1) Ph.D. in crystallography or protein biochemistry training with minimal 3-5 years’ working experience

2) Hands-on experience in protein crystallization, and protein expression and purification is optional.

3) Proficient in structure biology related software is plus.

4) Demonstrated managerial skill to guide groups through corporate change and growth.

5) Excellent verbal and writing skills in English are essential.

6) Strong communication skills and client interaction are required.

[Post Date: September 28, 2018]

Title: Postdoc University of Warsaw

An announcement for Post-doctoral position

Position of Post-doctoral Researcher in the OPUS project entitled

"More accurate models of the electrostatic potential of biological macromolecules and organic crystals necessary for proper interpretation of data from cryo-electron microscopy and from electron diffraction – feasibility study"

financed by NCN is open for application.

Project leader: dr hab. Paulina M. Dominiak, prof. UW

Available positions: 1

Project description:
The Dominiak’s group works on developing new methods of electron density modelling for X-ray and electron crystallography, chemistry and structural biology. The project aims at development of new models of electrostatic potentials for electron crystallography. The models will considerably deviate from the conventional spherical independent atom model currently used. With new models more information should be extracted from electron scattering experiments on biological macromolecules and organic crystals, and improved quality of geometric data and quantitative estimates of molecular electrostatic potentials should become easily available. For further information see http://cnbch.uw.edu.pl and http://www.chem.uw.edu.pl.

Position description:
You will be mainly responsible for development and verification of new databanks of atomic electron densities on the basis of existing procures published in: Acta Cryst. 2012, A68, 139; JCTC, 2014, 10, 1652; ChemPhysChem, 2016, 17, 2455; Acta Cryst. 2017, B73, 610.

We are looking for motivated candidates with:

-a PhD degree in chemistry or related fields at the moment of starting the job (PhD defended not later than 7 years ago according to NCN regulations, see www.ncn.gov.pl) -experience in crystallography OR/AND computational chemistry proven by scientific article publications -knowledge of macromolecular crystallography OR/AND proven experience in high-resolution x-ray diffraction charge density measurements -basic programing skills OR/AND practical experience in script usage/writing and proven ability to work with large amount of data -experience with structure refinement against electron diffraction or single particle cryoEM data will be an advantage -well-developed analytical skills -good knowledge of written and spoken English -written and spoken presentation skills -ability to work as part of a team We offer:
a temporary employment contract with the University of Warsaw:
-full time position
-a salary approx. 5000 PLN per month (net salary, after taxes and other
-for one year with a possible extension upto three years -appointment starting in November 2018 (the competition may be repeated until a suitable candidate who fulfils all requirements is found)

Required documents (in English):
-Curriculum Vitae (including list of scientific articles, conference presentations, awards, international internships, scholarships, workshops, participation in research projects), -a motivation letter (What are your scientific interests? What are your key strengths and achievements? Why do you want to work in the project?), -information on the processing of personal data (see the text below), -two recommendation letters (at least one from direct supervisor) sent by the referees directly to prof. Dominiak (pdomin@chem.uw.edu.pl).

Please submit the documents no later than 26 October 2018 to:
pdomin@chem.uw.edu.pl (PDF is the preferred format). E-mail entitled:
“Post-Doc position”

Selected candidates may be invited by e-mail, no later than 30 October 2018, to participate in interview. The interview will take place on 5 or 6 November 2018 in person or via Skype or phone. The results of the competition will be delivered to selected candidates by e-mail till 15 November 2018. In the case of not signing the contract by the candidate, due to the resignation, we reserve the right to choose the next candidate from the ranking list.

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[Post Date: September 28, 2018]

Title: Postdoc Florida State University

One postdoctoral position is available immediately in an enzymology laboratory to elucidate mechanisms of DNA/RNA synthesis, DNA lesion bypass, and base excision repair catalyzed by various human and viral DNA/RNA polymerases, and to mechanistically investigate gene editing enzymes including CRISPR/Cas9 and Cas13a. Background in structural biology (X-ray crystallography and/or CryoEM), biophysics, protein purification, and recombinant DNA techniques is preferred. An important criterion for selection will be the ability of the desired individual to pursue independent research in an active multi-disciplinary setting. Interested candidates should send a CV and a statement describing experience, goals, and reasons for the interest in this position, and arrange to have three letters of recommendation sent to: Dr. Zucai Suo, Eminent Professor and Dorian and John Blackmon Chair of Biomedical Science, Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL. Dr. Suo can be contacted by email (zucai.suo@med.fsu.edu). Further information about the research projects in the Suo Lab can be obtained from https://u.osu.edu/suolab/.

Employer: Florida State University College of Medicine
Location: Tallahassee, Florida
Salary: NIH guidelines for post-doctoral salaries + benefits
Discipline: Life Sciences, Biochemistry, Biology, Biophysics, Structural Biology, and Biomedical Sciences
Position Type: Full Time
Organization Type: Academia
Job Type: Postdoc

[Post Date: September 24, 2018]

Title: Staff Scientist
Website: https://careers-stjude.icims.com/jobs/4190/staff-scientist/job

Staff Scientist
Job ID: 39237, Department Structural Biology, Job Location: US-TN-Memphis

We are seeking outstanding biochemists, with expertise in protein purification and/or protein engineering to join our new Protein Technologies Center (PTC) within the Structural Biology Department at St. Jude Children’s Research Hospital. The PTC is a multidisciplinary team with capabilities in protein engineering, cloning, expression, purification, and analysis of proteins. The PTC is responsible for the optimization, production and assessment of difficult protein targets for structural studies, thereby supporting structural biologists and other researchers at St. Jude to focus on making big discoveries. This is a bench-based scientist role where you will be providing pivotal support to several projects both strategically and tactically.

1. Design, develop and optimize protein expression, purification and characterization methods like stability, size distribution and conformation
2. Engineer the proteins, including membrane proteins, immune molecules, complex multi-domain proteins and fusion partners (Chimeras) which would aid in the stabilization and/or increase the chance of success in protein production, purification and structure-function studies.
3. Purification and analysis of the recombinant proteins, preferably membrane proteins, using FPLC and U/HPLC and also maintenance of the chromatography systems
4. Contribution to the entire structural biology workflow: - cloning and expression in bacteria, insect or mammalian expression systems
5. Generate antibodies (or Synthetic Antigen Binders) through hybridoma, phage, yeast, or other panning technology
6. Work independently on the design, execution, and interpretation of experimental results
7. Train and mentor research associates, students and/or postdoctoral associates who seek to leverage the Protein Technologies Center’s capabilities at St. Jude

Minimum Education
PhD in the area of molecular biology, biochemistry, protein engineering, or any related discipline.

Minimum Experience
A minimum of five (5) years of relevant and productive (combined) years postdoctoral research associate or five (5) years of combined academic experience at the postdoctoral level or above.

Please send your CV and inquiries to ravi.kalathur@stjude.org

[Post Date: September 24, 2018]
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