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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.

Title: Structural Biology Scientist
Website: https://tinyurl.com/y7c38kne

Description:
Foghorn Therapeutics has a job opportunity for an early career PhD in Structural Biology. Please apply directly to the official posting:

http://foghorntherapeutics.applytojob.com/apply/nkSaJJ1Rrn/Scientist-Structural-Biology?referrer=20180209182508A5FGUVSWUYZTBVFU&channel=email

POSITION SUMMARY
TITLE: Scientist, Structural Biology
REPORTS TO: Senior Scientist, Drug Discovery
LOCATION: Cambridge, MA
COMPANY DESCRIPTION
Founded in 2016, Foghorn Therapeutics discovers and develops novel drugs to treat cancer and other serious medical disorders. The company seeks to discover novel therapeutics that target chromatin remodeling complexes. Foghorn uses a proprietary platform based on revolutionary advances in mechanistic understanding of disease.
POSITION DESCRIPTION
We are seeking a highly skilled and motivated structural biologist to become an integral member of the Foghorn team. This person will contribute to our goal of developing transformative therapeutics by planning and carrying out structural characterization of crucial drug targets. The main focus of this role will be protein crystallography but will require a willingness to find new ways to think about scientific challenges. We need someone who is passionate, driven, and ambitious to help us achieve our goal of improving patients’ lives.
Responsibilities include:
• Collaborating with colleagues in biochemistry, biology, and chemistry to develop structural biology strategy.
• Designing biophysics-grade protein constructs and assisting in the optimization of purification protocols.
• Crystallization, X-ray structure determination, and analysis of important drug targets.
• Providing regular updates to cross-functional teams and helping guide structure-based compound design in close collaboration with chemistry group.
• Participating in the management of collaborations with contract research organizations (CROs) and academic partners.
QUALIFICATIONS
• PhD in Structural Biology, Biophysics, Biochemistry or a closely related field, with a background in chemistry.
• Demonstrated competency in protein construct design and expression and purification strategies using bacterial, insect, and mammalian hosts. Experience with multi-protein complexes is a plus.
• Deep expertise in protein crystallization and X-ray structure determination of protein-ligand complexes.
• Extensive knowledge of protein structure and function, with the ability to articulately communicate structural information to a broad audience.
• Experience with other structural techniques (e.g. electron microscopy, small-angle X-ray scattering) is preferred.
• Excellent time management and communication skills.
• Ability to work in a fast-paced, team-driven environment, with a collaborative and proactive attitude.


[Post Date: February 16, 2018]

Title: Research Technician Vanderbilt University

Description:
The Spiller lab in the Department of Pharmacology at Vanderbilt University is seeking a Research Assistant to assist Dr. Professor Spiller in his laboratory. The Spiller lab is a structural biology lab focused on infectious disease and the host’s immune response. The job requires a moderate ability to work independently but also involves working directly with Dr. Spiller and other lab members to help determine crystal structures. The candidate will be expected to interact professionally with other lab members. Preference will be given to applicants with experience in some of the following responsibilities.

Molecular Biology
• Design and create new protein constructs for crystallization trials.
• Optimize protein expression of new protein constructs.
Protein Purification
• Design and carry out experiments on the basis of discussed plans with Dr. Spiller
• Analyze chromatography experiments.
Crystallization
• Design and carry out high throughput crystallization trials
• Optimize crystallization conditions

Interested applicants should send a CV and cover letter to Ben Spiller.

Benjamin.spiller@vanderbilt.edu


[Post Date: February 13, 2018]

Title: Postdoc NIH

Description:
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT, BETHESDA, MD AND SURROUNDING AREA

Position Description:
The research group of Dr. Anirban Banerjee at the National Institutes of Health (NIH) is seeking candidates for postdoctoral fellows . The broad interests of the lab are in membrane protein structure and function. We combine structural techniques such as macromolecular crystallography with biophysical and biochemical methods such as reconstitution based assays, high resolution microscopy and small molecule screening to investigate the structural bases of the mechanisms of a number of membrane proteins.
The lab has state-of-the-art equipment and facilities. We have dedicated periodic access to the 22-ID beamline at the APS, for crystallographers at the NIH, as well as access to 23-ID and 24-ID beam lines at the APS. Our laboratory is part of the Cell Biology and Neurobiology Branch in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). We also have an affiliation to the National Institute of Neurological Disorders and Stroke (NINDS).

Qualifications:
The candidates should hold a Ph. D. degree, be author of at least one first author publication and have a strong background in biochemistry or structural biology. Experience with basic molecular biology, protein expression, purification and biochemical characterization are required. Prior experience in membrane protein biochemistry or mammalian expression system for protein purification will be added advantages.

It is absolutely essential the candidate is motivated and prepared to put in the best efforts for fruition of the project goals. We are a small, friendly lab and ability to work as part of a cohesive group is important.

To Apply:
Interested candidates can send an e-mail to anirban.banerjee@nih.gov with a CV and a summary of previous research experience and future interests.

The NIH is dedicated to building a diverse community in its training and employment programs.


[Post Date: February 12, 2018]

Title: Tenure Track Faculty Position
Website: njms.rutgers.edu/departments/molecular_genetics/index.cfm

Description:
Rutgers Biomedical and Health Sciences

Faculty Position in Structural Biology and Disease

The Department of Microbiology, Biochemistry, and Molecular Genetics and the interdepartmental Center for Immunity and Inflammation at Rutgers New Jersey Medical School seeks an exceptional Structural Biologist for a tenure-track faculty position at the level of Assistant Professor. Rutgers New Jersey Medical School is located in Newark, NJ and is part of Rutgers Biomedical and Health Sciences (http://rbhs.rutgers.edu/), a division of Rutgers, The State University of New Jersey.

Applicants must have a Ph.D. and/or M.D. and at least 2 years of postdoctoral experience. Candidates will be expected to establish a high-impact, funded independent research program that is focused on the prevention or cure of disease as well as participate in medical and graduate school education. A competitive start-up package will be provided.

Information about the department may be found on our website at: http://njms.rutgers.edu/departments/molecular_genetics/index.cfm.

For consideration, applicants should submit by email to mbmg-search@njms.rutgers.edu: a cover letter, curriculum vitae, a summary of past research accomplishments and future research plans and the names, affiliations and email addresses of 3-4 references.

You may also submit an application by regular mail to:

Dr. David Kaback, Chair of Faculty Search Committee Department of Microbiology, Biochemistry and Molecular Genetics New Jersey Medical School Rutgers Biomedical and Health Sciences
225 Warren Street
Newark, NJ 07103

Rutgers University is an AA/EEO employer. All applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, disability or protected veteran status.


[Post Date: February 12, 2018]

Title: Postdoc ISMB
Website: https://tinyurl.com/y7xtwkcj

Description:
Postdoctoral researcher in the Robinson Lab at the Institute of Structural and Molecular Biology (ISMB) within Birkbeck College, London UK. We are seeking an ambitious and driven research scientist to investigate the structure and function of a biomedically important family of chromatin modifying complexes.

The position will involve interdisciplinary research combining biophysical and structural approaches (X-ray crystallography and
cryo-EM) and features exciting collaborative opportunities with groups at UCSF and the Institut Pasteur. The qualified candidate should have obtained a Ph.D. with a solid foundation in biophysical approaches and experience in biochemistry and structural biology.

The ISMB is a vibrant, multidisciplinary and collaborative research environment that bridges the Departments of Chemistry/Structural and Molecular Biology at University College London and the Department of Biological Sciences at Birkbeck. The ISMB is a UK centre of excellence for cryo-electron microscopy and X-ray crystallography. The EM suite currently houses a 300KeV Polara with K2 detector as well as FEI Tecnai F20, T12 and T10 for sample characterization and optimization.
Cryo-EM capabilities will be further strengthened by a recently purchased 300KeV FEI Titan Krios, to be delivered in early 2018. The X-ray lab comprises a robotics suite for liquid handling, tray setup, barcoding and imaging and an X-ray room for in-house diffraction experiments.

The full-time post is funded by the Medical Research Council for a period of up to five years, includes a competitive London-weighted salary and will be available from May 2018. For more information about the position and to apply, use the following link:

http://jobs.bbk.ac.uk/fe/tpl_birkbeckcollege01.asp?s=4A515F4E5A565B1A&jobid=66121,8848474812&key=118857330&c=35481286468798&pagestamp=sebepmfuvkhzehsxxn

Informal enquiries are welcome and can made via email to Dr Philip Robinson (p.robinson@mail.cryst.bbk.ac.uk).


[Post Date: February 12, 2018]

Title: Postdoc
Website: https://www.wehi.edu.au/research-officer-lucet-laboratory

Description:
Postdoctoral position, Walter and Eliza Hall Institute of Medical Research.

If you are interested in understanding the intricacy of Kinases/Pseudokinases regulation using CryoEM, X-ray crystallography, Imaging and chemical biology approaches, we have an exciting opportunity for a postdoctoral position at the Walter and Eliza Hall Institute of Medical Research, reporting to Dr Isabelle Lucet.

The position is offered for one year in the first instance.
Check out the full details on:
https://www.wehi.edu.au/research-officer-lucet-laboratory

Closing date: 28 February 2018
Contact email:lucet.i@wehi.edu.au



[Post Date: February 12, 2018]

Title: Postdoc University of Cambridge
Website: http://www.jobs.cam.ac.uk/job/16385/

Description:
We have an opportunity for a postdoctoral researcher in my lab in the
School of Biological Sciences, Department of Pathology, University of
Cambridge, UK. The successful applicant will continue our work on
bacterial multi drug resistance pumps, (e.g. see our recent PNAS paper
here (http://www.pnas.org/content/114/47/12572.full) and other medically important membrane machinery.

We're looking for someone with a PhD in structural
biology/biochemistry/biophysics and demonstrable experience in X-ray crystallography and/or cryoEM. Funds are available until August 2020 in the first instance.

Full job description is here, along with details of how to apply through the University jobs portal.



[Post Date: February 09, 2018]

Title: Research Assistant
Website: https://www.recruit.ox.ac.uk
Email: recruitment@oncology.ox.ac.uk

Description:
Research Assistant

Department of Oncology, Weatherall Institute for Molecular Medicine, Headington, Oxford.
Grade 6: £28,098 - £33,518 p.a.

We have an exciting opportunity for a Research Assistant, who will be based at the Weatherall Institute of Molecular Medicine, reporting to Professor Peter McHugh. You will be part of a dynamic and ambitious research group studying DNA repair focusing on the structure and function of a large multiprotein complex involved in human DNA repair, integrating structural biology with biochemistry and cell biology.

Showing a high level of organisation and independence, you will assist with the day-to-day running of several aspects of the lab and will offer assistance in operating the eukaryotic expression and protein purification platform (from E.coli, yeast, insect and mammalian cells).

A good degree in biochemistry or closely related field is essential, together with familiarity with general molecular biology techniques. Some experience in cloning, expression and protein purification systems is also essential. Knowledge of DNA repair and experience in mammalian and/or insect tissue culture, biophysical techniques and structural biology would be advantageous

This is a full-time post, offered for 2 years in the first instance.

All applicants must complete a short application form and upload a CV and supporting statement.

The closing date for applications is 12.00 noon on 23 February 2018.

Additinal infromation and application via the University of Oxford's online recruitment system.

Vacancy ID : 132955


[Post Date: February 08, 2018]

Title: Postdoc University of Sheffield
Website: http://www.jobs.ac.uk/job/BHN194/postdoctoral-research-associate-in-structural-biology/

Description:
We seek to appoint a Research Associate in Structural Biology to work on the development of inhibitors of bacterial flap endonucleases (FEN) as potential new antimicrobial drugs. This is initially for a 16-month period to develop a new generation of anti-bacterial agents capable of targeting antibiotic resistant bacteria.

You will join a team during structure-based drug design to develop inhibitors of essential bacterial enzymes. Your role will be to prepare recombinant proteins, crystallise them and determine their X-ray structures. We welcome highly dedicated and enthusiastic candidates with the ability to develop their computer and wet laboratory skills. You will possess or have submitted a PhD degree in X-ray crystallography of protein molecules and have an interest in applying your expertise to structure-based drug development. Success in this post may lead to an opportunity to continue on the project subject to further funding being obtained.

FEN enzymes are involved in DNA replication and repair ( Nature Structural and Molecular Biology, 2016 :640-6. doi: 10.1038/nsmb.3241). We are using site-directed mutagenesis, crystallography and kinetic studies to assist in a structure-based drug design approach. We are housed within well-equipped laboratories with access to excellent core facilities with state-of-the-art equipment for e.g. biological mass spectrometry, Cryo-EM, X-ray crystallography, liquid handling robotics for high throughput screening & crystallization, a range of microscopy facilities, etc. You will join a multidisciplinary team representing a collaboration between The Sheffield Institute for Nucleic Acids (SInfoNiA) and The Flory Institute for Host-pathogen Interactions.

This post is fixed term for 16 months, with a start date of 1st March 2018 (or as soon as possible thereafter). Closing date 19th Feb.

Previous applicants need not apply. Formal applications to be made via the UoS web site.


[Post Date: February 08, 2018]

Title: Postdoc University of Oxford
Website: https://tinyurl.com/487m39b

Description:
Postdoctoral Research Assistant in Biochemistry

Sir William Dunn School of Pathology, South Parks Road, Oxford, UK

Grade 7: £31,604 - £38,833 p.a.

A postdoctoral position is available in Dr Ivan Ahel’s group at the Sir William Dunn School of Pathology, University of Oxford to study the role of ADP-ribosylation signalling in microbial pathogenicity (Rack et al, Mol Cell, 2015; Jankevicius et al, Mol Cell, 2016). The project will involve a combination of biochemistry and structural biology techniques. The post is available for 2 years in the first instance.

Applicants should have a PhD in biology or a related subject. A high level of competence in biochemistry and/or structural biology is required and relevant experience demonstrated by first author publications in high-profile journals. The ideal candidate should be organised, highly motivated and able to work independently as well as part of a team.

Informal enquiries should be directed to Dr Ivan Ahel: ivan.ahel@path.ox.ac.uk.

If you are interested in this role, and have the skills and experience we are looking for, please apply online. You will be required to upload a CV and supporting statement as part of your online application.

The closing date for applications is 12.00 midday on Monday 5 March 2018. Interviews will be held as soon as possible thereafter.

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_details_form.jobspec?p_id=133257


[Post Date: February 07, 2018]

Title: Postdoc CIBIO Italy

Description:
A postdoctoral position is available in the Laboratory of Protein Crystallography - Centre for Integrative Biology - University of Trento, Italy. The project aims to generate new classes of biosensors for drug discovery, diagnostics and in vitro – in vivo imaging. Candidates should have a PhD in a relevant subject area and experience in basic Molecular Biology and Biochemistry, in particular in cloning techniques and protein expression and purification. Experience in one or more of the following is an advantage:
-Structural/functional analyses using biochemical/biophysical techniques
-High-throughput screening
-Cell culture
-X-ray crystallography
-Molecular docking

If interested, please email your CV, a description of past research experiences, and 2 references to: graziano.lolli@unitn.it ?

Additional information on the lab can be found at: http://www.cibio.unitn.it/504/protein-crystallography-and-structure-based-drug-design

Additional information on CIBIO can be found at: http://www.cibio.unitn.it/ ?


[Post Date: February 06, 2018]

Title: Structural Biologist Position
Website: https://morphictx.com/careers/opportunities/#research-scientist-in-structural-biology

Description:
Please apply directly through our website: https://morphictx.com/careers/opportunities/#research-scientist-in-structural-biology Morphic Therapeutic is seeking a highly skilled and motivated Research Scientist trained in the field of structural biology, biophysics and protein biochemistry. Join us in an exciting early stage well-funded start-up with strong venture and strategic funding, leading founder and advisors, and an experienced team ready to tackle the challenges of the integrin drug discovery. We are currently seeking a protein crystallographer to join our team working on the integrin family of proteins to do protein design, expression, purification and structure determination to enable the discovery of small molecule therapeutics. This position offers the right candidate a chance to work on state-of-the-art drug discovery science, in an environment where discoveries can be immediately translated to treatments for serious diseases like inflammatory bowel disease, fibrosis, and cancer. Primary responsibilities: Set up crystallization/optimization trials with state-of-art robotics Obtaining ligand-bound structures by soaking/co-crystallization, and performing structure refinement and analysis Structure determination with experimental phasing and molecular replacement Design and development of biochemical and biophysical assays to characterize molecular interactions Design, express, and purify novel integrin complexes using mammalian expression systems Present results (written and oral) to internal and external audiences Required Qualifications and skills: PhD in Structural Biology, Biophysics, Biochemistry or a closely related field. Demonstrated expertise and track records in protein crystallization and X-ray crystallography Extensive knowledge and experience in protein expression, purification and characterization are required. Hands-on experience in mammalian expression systems is highly preferred but not required. Experience with Schrödinger’s Drug Design Suite, structure-guided drug design, and bioinformatics is preferred. Deep knowledge of protein structure and function Excellent time management as well as oral and written communication skills. Ability to quickly and effectively operate, communicate and influence decision making within cross-functional and multi-disciplinary research team.

[Post Date: January 31, 2018]

Title: Research Specialist II
Website: https://www.cedars-sinai.edu/Research/Research-Labs/Bilsborough-Lab/

Description:
The Cedars -Sinai F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute (IBIRI) is searching for a highly motivated Research Specialist II to be part of Cedars-Sinai's commitment to Precision Health through an exciting opportunity within our IBD Drug Discovery and Development Unit (IBD3). We are a multidisciplinary basic, translational and clinical program devoted to mucosal inflammation. The mission of the IBD3 unit is to use personalized medicine approaches to predict the success of current and future therapeutic for inflammatory bowel diseases. The IBD3 program is u uniquely structured to join academic science with industry partners to discover and validate new therapeutic targets, accelerate drug development through patient stratification, and rescue and repurpose failed drugs by identifying drug responsive patient populations. The unit embodies a spirit of discovery with world leaders and research scientists on the care and management of IBD.

More information can be found at: https://www.cedars-sinai.edu/Research/Research-Labs/Bilsborough-Lab/

The IBD3 unit is seeking a mission-focused Research Specialist II, with the expertise in the development of protein expression and purification strategies to support ongoing drug discovery and development needs. Under the leadership of the IBD3 unit Director, the Research Specialist II will utilize a solid foundation in research and experience with techniques associated with a specific area of research. Incumbent will be capable of exercising independent judgment while developing and implementing research programs, project planning, enrollment of patients, experimental protocols and procedures, database development and analysis including evaluating and interpreting results. Will supervise lab activities, including research grant management, human resources, responsibility delegation, and provide training to other individuals who may be assigned to the project, study, or laboratory. Reports to and works closely with Principal Investigator and has independent supervision of a laboratory or program. Will prepare grant proposals, publications, and presentations. Will function as a bridge between research and clinical programs which may have local and national contributors and investigators relying on information provided. Will have delegated authority to make substantive decisions and commitments in accord with the established goals and objectives of the laboratory or program.

Essential Job Duties and Responsibilities:

- Acts as a project lead and coordinator interacting with collaborators, clinical research personnel and researchers as part of a research team.
- Participates in all aspects of clinical development and study management (protocol design, enrollment of patients, development and implementation of protocols, and if applicable, submission of IRB applications and approvals).
- Follows established procedures or protocols to perform laboratory tests and/or experiments which will include: basic tissue culture, immunoassays, molecular biology techniques, microscopy, animal preparation (e.g. tail vein injections) and surgery.
- Provides scientific expertise to ongoing and future trials.
Identify and resolve common problems involved in routine research assays.
- Establishes and maintains relationships with clinical investigators and manages internal and external collaborative research projects.
- Acts as a scientific resource for the affiliated pre-clinical research laboratory (e.g., assisted with experimental designs, data analysis, interpretation of scientific literature).
- Supervises, leads, and trains other individuals assigned to the lab.
- Prepares grant applications and oversees submission process, including writing of grant proposal.
- Capable of exercising independent judgment while participating in the planning of experiments and evaluating and interpreting results.
- Operates appropriate laboratory equipment.
- Monitors inventory levels, orders materials and supplies in accordance with established policies and procedures.
- Operates lab computers for data entry and maintains accurate data records.
- Uses various software applications, such as spreadsheets, electronic mail, World Wide Web, statistical packages, and graphics packages to assemble, manipulate and/or format data and/or test reports.

Department and/or Unit Specific:

- Must demonstrate strong biochemistry skills and keeps up-to-date with the latest technologies to continually improve operational procedures.
- Able to Implement a variety of expression systems including e.coli, mammalian and baculovirus cell culture
- Hands on expertise in construct design, protein expression and purification
- Proven experience in difficult-to-express and purify proteins such as membrane proteins, enzymes and Fc-fusion for biologics, X-ray crystallography and cryo-EM
- Works closely with computational scientists for structure-function studies and structure based drug design
- Uses protein biochemistry and structural biology knowledge to outline strategies and workflows for optimization of protein production needs
- Supports assay development in line with the needs of projects within the drug development group
- Supervise and train laboratory staff in assay development and protein expression and production technologies as needed.
- Manages collaborations with CRO’s for protein production, structure determination and manufacturing of proteins and protein therapeutics to ensure timelines, budgets and project goals are met.
- Communicates with other groups within Cedars-Sinai to facilitate a collaborative environment for the optimization of data analysis and to facilitate drug discovery and development efforts.
- Maintains strict adherence to research compliance regulatory standards for human and animal subject use.
- Ensures compliance with state and federal laws, accreditation, professional and regulatory agency standards including quality assurance and licensure requirements within the divisions. Assist in establishing and maintaining a quality assurance program acceptable to CSMC as required by The Joint Commission, state and other agencies, which shall include a systematic review of the quality, safety, and appropriateness of services rendered.
- Works to ensure internal budgets and goals are met and generates reports and presentations to ensure appropriate communication of findings.

Educational Requirements:
BS/BA, or equivalent, in biological sciences, chemistry, or related discipline required. MS or PhD preferred.

Experience:
Five to seven (5-7) years of experience in area of research specialty and with post-undergraduate experience in a comparable laboratory performing relevant techniques. Training and knowledge in the design and conduct of clinical trials. Expertise in translational biomedical research. Knowledge of biostatistics as it is applied to clinical trial data analysis. Ability to communicate scientific and clinical information in the context of multidisciplinary teams. Must demonstrate excellent communication skills, written and verbal. Strong computer skills are essential.

- PhD or highest degree in their field, preferred.
- Demonstrated significant, original, and creative contributions to a research or creative program or project.
- Completion of postdoctoral appointment in area of specialization.
- Minimum of 3 years as a postdoctoral fellow. Completion of postdoctoral appointment in area of specialization.
- Knowledge of PI’s area of research specialization. Demonstrated technical competency in a variety of research techniques and protocols.

Attention Applicants:

If you are the right candidate for this position, please e-mail address below, include cover letter with your research interests and career aims, CV (please include technology and skills proficient in) and contact information for three references.

Janine Bilsborough, PhD
Director, Inflammatory Bowel Disease Drug Discovery & Development
Email: Janine.Bilsborough@cshs.org


[Post Date: January 30, 2018]

Title: Science Technician
Website: https://www.jic.ac.uk/training-careers/vacancies/2018/01/science-technician-protein-crystallography-and-bio/

Description:
Science Technician (Protein Crystallography and Biophysical Analysis Facilities)

Applications are invited for an enthusiastic and motivated individual to join the John Innes Centre as a Science Technician supporting our Protein Crystallography and Biophysical Analysis facilities.

Background:

The John Innes Centre is an independent, international centre of excellence in plant and microbial sciences.

The Protein X-ray Crystallography (PX) facility provides services and expertise for the determination of the three-dimensional structures of proteins of interest. The Biophysical Analysis (BA) facility provides services and expertise to study important biomolecular interactions using the techniques of Surface Plasmon Resonance and Isothermal Titration Calorimetry. Together these facilities provide deep insights into molecular interactions, gene regulation, enzyme mechanism, protein function and protein evolution.

The role:

We are seeking a science technician to support the work of the protein crystallography (PX) and biophysical analysis (BA) facilities. 70% of the time would be spent supporting the PX facility and 30% supporting the BA facility. The major responsibilities would include looking after specialist lab equipment, replenishing laboratory stocks, and liaising with users of the facilities to ensure that the service delivered is of excellent scientific quality.

The ideal candidate:

We are keen to employ an enthusiastic person with proven laboratory skills who is eager to work on a scientific facility providing excellent expertise and services to both internal and external users. Candidates should possess a BSc or equivalent in a biological subject, or possess significant relevant experience of working in a laboratory setting.

The candidate must to be able to work independently, have excellent organisational skills and good oral and written communication skills. The ability to act quickly to give advice or troubleshoot any issues is also very important. The ability to work occasional unsociable hours is also required.

Additional information:

Salary on appointment will be within the range £24,300 to £29,750 per annum depending on qualifications and experience. This post is for an initial contract of three years.

We welcome applications from candidates seeking job-share, part-time or other flexible working arrangements.

For further information and details of how to apply, please visit our web site http://jobs.jic.ac.uk or contact the Human Resources team on 01603 450462 or nbi.recruitment@nbi.ac.uk quoting reference 1003404.

We are an equal opportunities employer, actively supporting inclusivity and diversity. As a Disability Confident organisation, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy. The John Innes Centre is also proud to hold a Gold Award from Athena SWAN and is a member of Stonewall’s Diversity Champions programme.

The closing date for applications will be 16th Feb.


[Post Date: January 29, 2018]

Title: Postdoc Bergen, Norway
Website: https://tinyurl.com/y9te6drl

Description:
Postdoc at the University of Bergen (Norway) for structure-based hit discovery for targets for antibiotics.

Looking for somebody with experience in at least one of the following areas:
X-ray crystallography of macromolecules
Assay development using surface plasmon resonance (SPR) or biolayer interferometry (BLI)
Fragment screening

Additional experience in any of the following fields will be an advantage:
Structure-based ligand design using computational methods
Recombinant protein expression and purification
Diffraction data collection at synchrotron beamlines


[Post Date: January 29, 2018]

Title: Postdoc SUSTech, Shenzhen, China

Description:
Two postdoctoral positions are currently available in the structural biology laboratory of Dr. Zhiyi Wei (http://bio.sustc.edu.cn/en/?p=189) at Department of Biology, Southern University of Science and Technology (SUSTech, Shenzhen, China). Our research interests is to uncover structural basis of large macromolecular assemblies in neuronal transmembrane signaling and cell-cell/matrix adhesion (Mol Cell, 2011; PNAS, 2013; eLife, 2014; PNAS, 2014; Nature, 2014; PNAS, 2017).

We offer an internationally competitive salary and benefits. Shenzhen government provides additional postdoctoral fellowship for Chinese nationals. The research work will be conducted at the Research Center for Life Science, which is equipped with state-of-the-art facilities for X-ray crystallography (Rigaku-007 plus Pilatus detector, crystallization robot), protein chemistry (BiaCore T200, PEAQ-ITC, MALS, etc.), and cell imaging. A cryoEM center is currently under construction, equipped with two Titan-Krios, one Talos and several 120kev EM machines, in the same building with our department. The position can apply research funds as PI for future career development.

Candidates should have received (or expect to receive) a Ph.D. in biochemistry or structural biology with a strong publication record. Candidates have experience with mammalian cell culture, cryoEM, or membrane proteins is a plus. Candidates should be highly motivated, have team-work spirit, and be able to work independently.

If you are interested in this position, please send your CV, including contact information for 3 references to weizy@sustc.edu.cn.


[Post Date: January 29, 2018]

Title: Postdoc University of Cambridge
Website: http://www.jobs.cam.ac.uk/job/16385/

Description:
We have an opportunity for a postdoctoral researcher in my lab in the School of Biological Sciences, Department of Pathology, University of Cambridge, UK. The successful applicant will continue our work on bacterial multidrug resistance pumps, (e.g. see our recent PNAS paper here (http://www.pnas.org/content/114/47/12572.full) and other medically important membrane machineries.

We're looking for someone with a PhD in structural biology/biochemistry/biophysics and demonstrable experience in X-ray crystallography and/or cryoEM. Funds are available until August 2020 in the first instance. Full job description is here, along with details of how to apply through the University jobs portal:
http://www.jobs.cam.ac.uk/job/16385/


[Post Date: January 24, 2018]

Title: Research Specialist II
Website: https://www.cedars-sinai.edu/Research/Research-Labs/Bilsborough-Lab/

Description:
The Cedars -Sinai F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute (IBIRI) is searching for a highly motivated Research Specialist II to be part of Cedars-Sinai's commitment to Precision Health through an exciting opportunity within our IBD Drug Discovery and Development Unit (IBD3). We are a multidisciplinary basic, translational and clinical program devoted to mucosal inflammation. The mission of the IBD3 unit is to use personalized medicine approaches to predict the success of current and future therapeutic for inflammatory bowel diseases. The IBD3 program is u uniquely structured to join academic science with industry partners to discover and validate new therapeutic targets, accelerate drug development through patient stratification, and rescue and repurpose failed drugs by identifying drug responsive patient populations. The unit embodies a spirit of discovery with world leaders and research scientists on the care and management of IBD.

More information can be found at: https://www.cedars-sinai.edu/Research/Research-Labs/Bilsborough-Lab/

The IBD3 unit is seeking a mission-focused Research Specialist II, with the expertise in the development of protein expression and purification strategies to support ongoing drug discovery and development needs. Under the leadership of the IBD3 unit Director, the Research Specialist II will utilize a solid foundation in research and experience with techniques associated with a specific area of research. Incumbent will be capable of exercising independent judgment while developing and implementing research programs, project planning, enrollment of patients, experimental protocols and procedures, database development and analysis including evaluating and interpreting results. Will supervise lab activities, including research grant management, human resources, responsibility delegation, and provide training to other individuals who may be assigned to the project, study, or laboratory. Reports to and works closely with Principal Investigator and has independent supervision of a laboratory or program. Will prepare grant proposals, publications, and presentations. Will function as a bridge between research and clinical programs which may have local and national contributors and investigators relying on information provided. Will have delegated authority to make substantive decisions and commitments in accord with the established goals and objectives of the laboratory or program.

Essential Job Duties and Responsibilities:

- Acts as a project lead and coordinator interacting with collaborators, clinical research personnel and researchers as part of a research team.
- Participates in all aspects of clinical development and study management (protocol design, enrollment of patients, development and implementation of protocols, and if applicable, submission of IRB applications and approvals).
- Follows established procedures or protocols to perform laboratory tests and/or experiments which will include: basic tissue culture, immunoassays, molecular biology techniques, microscopy, animal preparation (e.g. tail vein injections) and surgery.
- Provides scientific expertise to ongoing and future trials.
Identify and resolve common problems involved in routine research assays.
- Establishes and maintains relationships with clinical investigators and manages internal and external collaborative research projects.
- Acts as a scientific resource for the affiliated pre-clinical research laboratory (e.g., assisted with experimental designs, data analysis, interpretation of scientific literature).
- Supervises, leads, and trains other individuals assigned to the lab.
- Prepares grant applications and oversees submission process, including writing of grant proposal.
- Capable of exercising independent judgment while participating in the planning of experiments and evaluating and interpreting results.
- Operates appropriate laboratory equipment.
- Monitors inventory levels, orders materials and supplies in accordance with established policies and procedures.
- Operates lab computers for data entry and maintains accurate data records.
- Uses various software applications, such as spreadsheets, electronic mail, World Wide Web, statistical packages, and graphics packages to assemble, manipulate and/or format data and/or test reports.

Department and/or Unit Specific:

- Must demonstrate strong biochemistry skills and keeps up-to-date with the latest technologies to continually improve operational procedures.
- Able to Implement a variety of expression systems including e.coli, mammalian and baculovirus cell culture
- Hands on expertise in construct design, protein expression and purification
- Proven experience in difficult-to-express and purify proteins such as membrane proteins, enzymes and Fc-fusion for biologics, X-ray crystallography and cryo-EM
- Works closely with computational scientists for structure-function studies and structure based drug design
- Uses protein biochemistry and structural biology knowledge to outline strategies and workflows for optimization of protein production needs
- Supports assay development in line with the needs of projects within the drug development group
- Supervise and train laboratory staff in assay development and protein expression and production technologies as needed.
- Manages collaborations with CRO’s for protein production, structure determination and manufacturing of proteins and protein therapeutics to ensure timelines, budgets and project goals are met.
- Communicates with other groups within Cedars-Sinai to facilitate a collaborative environment for the optimization of data analysis and to facilitate drug discovery and development efforts.
- Maintains strict adherence to research compliance regulatory standards for human and animal subject use.
- Ensures compliance with state and federal laws, accreditation, professional and regulatory agency standards including quality assurance and licensure requirements within the divisions. Assist in establishing and maintaining a quality assurance program acceptable to CSMC as required by The Joint Commission, state and other agencies, which shall include a systematic review of the quality, safety, and appropriateness of services rendered.
- Works to ensure internal budgets and goals are met and generates reports and presentations to ensure appropriate communication of findings.

Educational Requirements:
BS/BA, or equivalent, in biological sciences, chemistry, or related discipline required. MS or PhD preferred.

Experience:
Five to seven (5-7) years of experience in area of research specialty and with post-undergraduate experience in a comparable laboratory performing relevant techniques. Training and knowledge in the design and conduct of clinical trials. Expertise in translational biomedical research. Knowledge of biostatistics as it is applied to clinical trial data analysis. Ability to communicate scientific and clinical information in the context of multidisciplinary teams. Must demonstrate excellent communication skills, written and verbal. Strong computer skills are essential.

- PhD or highest degree in their field, preferred.
- Demonstrated significant, original, and creative contributions to a research or creative program or project.
- Completion of postdoctoral appointment in area of specialization.
- Minimum of 3 years as a postdoctoral fellow. Completion of postdoctoral appointment in area of specialization.
- Knowledge of PI’s area of research specialization. Demonstrated technical competency in a variety of research techniques and protocols.

Attention Applicants:

If you are the right candidate for this position, please e-mail address below, include cover letter with your research interests and career aims, CV (please include technology and skills proficient in) and contact information for three references.

Janine Bilsborough, PhD
Director, Inflammatory Bowel Disease Drug Discovery & Development
Email: Janine.Bilsborough@cshs.org


[Post Date: January 23, 2018]

Title: Scientist, Structural Biology
Website: https://tinyurl.com/y9onsdmg

Description:
We have an opening in our structural biology group in Waltham MA for a scientist to support small molecule drug discovery efforts. Experience with membrane proteins is desired. If interested, please apply through the Sanofi portal.
https://sanofi.wd3.myworkdayjobs.com/en-US/SanofiCareers/job/US--Waltham--Genzyme-Lab---153-Second-Ave/Scientist--Structural-Biology_R825384

Scientist, Structural Biology

Job Responsibilities/Department Description:
We are seeking a Scientist to join our Boston-area structural biology group conducting drug design research in diverse therapeutic areas. Our group integrates with multidisciplinary project teams to accelerate drug discovery on innovative and challenging targets. Responsibilities include construct design, development and optimization of protein purification protocols, purification and characterization of crystallization-grade and cryo-EM-grade protein, as well as crystal screening and optimization. A scientist with structure solution and interpretation skills will solve novel structures and drive drug design workflows. A scientist with membrane protein experience would have an opportunity to drive projects in this field in conjunction with leading academic partners. The successful candidate must be an enthusiastic team player with excellent communication skills and must bring curiosity and a desire to make an impact in the workplace.

Basic Qualifications:
PhD in Biochemistry or a related field (Biology, Cell Biology, Biotechnology, etc.) and 2+ years of experience in protein expression, purification, crystallization and characterization for structural studies, or BS degree and 8+ years of relevant experience.

Preferred Qualifications:
Extensive track record with purification and crystallization of challenging proteins, e.g., membrane proteins. Experience with biophysical characterization (stability and binding assays) and structure determination. Industrial experience.

Sanofi US Services, Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. #GD-SA #LI-SA

Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions. With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe.


[Post Date: January 21, 2018]

Title: Staff Scientist SSRL

Description:
The Structural Molecular Biology (SMB) program at the Stanford Synchrotron Radiation Lightsource (SSRL), Stanford University, a national user research facility and a Directorate of the SLAC National Accelerator Laboratory, has an immediate opening for a Ph.D. scientist to engage in the development, user operations, and science of its x-ray macromolecular crystallography synchrotron facilities. The intense x-ray radiation produced by the SPEAR3 storage ring at SSRL is used by visiting researchers from around the world to conduct experiments in structural biology and other scientific fields. The SMB program supports the development and use of five beam lines dedicated to macromolecular crystallography and provides leading-edge technology within a user-friendly environment. The group also supports the development and use of a standard goniometer-based setup at the Linac Coherent Light Source
(LCLS) MFX station. The scientist will be appointed as a Stanford University Academic Staff - Research Associate with working title Associate Staff Scientist.

The successful candidate will be involved in development of new instrumentation and methodologies for micro-beam diffraction studies, serial crystallography, and room temperature crystallography at SSRL and LCLS-MFX, and in collaborative research projects that take advantage of these developments. Development efforts will also focus on in-situ spectroscopic measurements using single crystals (including UV-Visible Absorption micro-Spectrophotometry, Raman Difference Spectroscopy and EPR). All activities will be carried out in close collaboration with other scientists, engineers, software developers and technicians.

The successful candidate will join a strong scientific, user-support and development team. Duties shared by all members of this group include aligning beam line components, optimizing beam quality, testing beam line systems, instructing users on the proper operation of beam line equipment, training and advising users in crystallography data collection and data processing techniques, and diagnosing and addressing problems with beam line optics, instrumentation and software. A requirement is being accessible to users occasionally outside of regular working hours. The Associate Staff Scientist may also participate in the construction of new beam line facilities and in the design, procurement, and implementation of new or further developed beam line hardware.

Qualifications:
A Ph.D. degree in biophysics, physics, biochemistry, structural biology, chemistry or a related field and post-doctoral experience in the use of x-ray diffraction methods, with preference in the field of macromolecular crystallography. Excellent written and verbal communication skills required. The ability to work independently and in a team environment required. The ability to work and communicate effectively with a diverse population required.

Desired Qualifications/Skills:

*Extensive experience with the use, development, and/or repair of x-ray optics, experimental equipment and/or synchrotron radiation instrumentation highly desirable.
*Experience in data processing and analysis of serial diffraction data and the use of injector-based methods for sample delivery highly desirable.
*A track record of scientific productivity through publications highly desirable.
*Experience with computer management for Linux systems, computer programming experience using Python, C/C++, Java, or TCL/TK and scripting languages a plus.
*Strong communication skills demonstrated through teaching roles and invited lectures at conferences a plus.

Stanford is an equal employment opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law. Stanford also welcomes applications from others who would bring additional dimensions to the University's research mission.

For additional information on our research activities, please visit http://smb.slac.stanford.edu/ or contact Dr. Aina Cohen at acohen@slac.stanford.edu. Please send your application, CV and the names of three references with contact information to Ms. Evelyn Castaneda, evelync@slac.stanford.edu.


[Post Date: January 19, 2018]

Title: Postdoc University of Oklahoma
Website: http://www.duerfeldtlabs.com/

Description:
The Duerfeldt Lab (www.duerfeldtlabs.com) in the Department of Chemistry & Biochemistry at the University of Oklahoma has an immediate opening for a highly-motivated postdoc trained in structural biology, microbiology, and/or molecular biology. The major research interest of the lab is to exploit bacterial enzyme/pathway activation as a strategy to diminish microbial fitness and/or pathogenicity. The ideal applicant should have an interest in determining the structure, function, and essentiality of putative targets within pathogenic organisms to uncover their biological significance and therapeutic potential. While the position offers the opportunity to contribute to a number of initiatives, the focus of this position is to contribute to our ongoing interrogation of the ClpP system in Clostridium difficile. This represents a great opportunity for scientists interested in entering the C. difficile research community, especially in the structural and microbiology fields.

We are located on the same floor as the University of Oklahoma’s Structural Biology Center of Biomedical Research Excellence (COBRE) and as a COBRE supported lab, the Duerfeldt Group has prioritized access to all equipment, facilities, and expertise in the COBRE cores. More information about the cores can be found at structuralbiology.ou.edu/.

Start date: as soon as possible.

To apply, please send a CV, research summary, and contact information for 3 references to adam.duerfeldt@ou.edu. Only complete applications will be reviewed.


[Post Date: January 19, 2018]

Title: Postdoc
Website: http://ccalmettes.profs.inrs.ca/

Description:
Postdoctoral Fellowship in Structural Microbiology

Project description: A postdoctoral position is available immediately in the research group of Assistant Prof. Charles Calmettes at the Centre INRS-Institut Armand Frappier in Laval (Greater Montreal, Canada) to work on a joint research project with the group of Dr. Hilde de Reuse at the Institut Pasteur (Paris, France). For this position we are looking for a talented, highly skilled, and motivated postdoc with a proven track record in the areas of structural and functional analysis of membrane proteins. The successful candidate is expected to dissect the structure and function of bacterial proteins (membrane and soluble proteins) identified as potential new drug targets, using a combination of X-ray crystallography and biochemical techniques.

The applicant must have a PhD in a relevant field, such as membrane protein, biochemistry or structural biology. Preference will be given to candidate with protein expression and purification skills, and with a solid knowledge in protein characterization and biophysical methods. Experience in X-ray crystallography is preferred but not mandatory. The applicant will be an enthusiastic scientist who demonstrates excellence, creativity, commitment to research, and effective communication skills. The Centre INRS-Institut Armand Frappier offers a French/English bilingual environment.

Salary range: Applicants must have completed their PhD degrees within the last 4 years. The position is funded for two years with possibility of extension based on performance. The salary range for the position is $40,000 to $50,000 per year.

Starting date: Review of applications begins immediately and will continue until the position is filled. Send your CV and a cover letter in PDF to charles.calmettes@iaf.inrs.ca. Successful candidates will be notified for interviews. Anticipated starting date is February 2018, or early 2018.

Institution: INRS–Institut Armand-Frappier Research Center, is a university dedicated to fundamental and applied research in the field of infectious diseases, immunity, and pharmaco-chemistry. The Institute has internationally recognized expertise and is considered a hub for health research in Quebec. The INRS-IAF campus is located in the greater Montreal area at the Laval Scientific and High Technology Park, in close proximity to a number of pharmaceutical and biotech companies.

Questions? Pr Charles Calmettes, Ph.D.
E-mail : charles.calmettes@iaf.inrs.ca
Lab webpage: http://ccalmettes.profs.inrs.ca/ (English) or http://www.inrs.ca/charles-calmettes (French)


[Post Date: January 16, 2018]

Title: Scientist Positions

Description:
Two permanent positions in structural biology are available at the NPL (National Physical Laboratory) in the BioMetrology group.
The BioMetrology group within the NPL has expertise in high-resolution measurements including protein crystallography, cryo-EM, 4D (spatial and temporal) high-resolution microscopy and spectroscopy, and biophysical characterisation such ITC and SPR.

Position 1: Higher Research Scientist
We wish to recruit a highly motivated PhD-level scientist (or equivalent experience) to help on the development of structural biology capabilities addressing the challenges of membrane proteins as drug targets, antimicrobial discovery and synthetic biology. The candidate will be involved in structural biology projects using x-ray crystallography, cryo-EM and XFEL approaches. The successful candidate will be expected to perform research, produce research reports and contribute to scientific articles.

Desirable skills and experience:
- Experience in molecular biology
- Experience in protein expression (insect cells and e.coli) and purification
- Solid knowledge in protein characterization and biophysical methods
- Experience in x-ray crystallography and/or cryo-EM
- Experience is membrane protein research will be an advantage


Position 2: Research Scientist
The candidate will provide experimental support in the areas of membrane protein production (bacteria, yeast and insect cells), biophysics, membrane protein crystallisation (for x-ray and XFEL) and Cryo-EM. The successful candidate will work with a team of highly skilled scientists to ensure the timely delivery of research objectives. The scientist will be expected to perform research, produce research reports and contribute to scientific articles.

Desirable skills and experience:
- Relevant degree or scientific experience
- Passionate about science and research
- Strong communication skills
- Ability to work alone and as part of a team
- Experience in protein production and crystallisation would be an advantage


The candidates will be working under Dr Isabel Moraes leadership (http://www.npl.co.uk/people/isabel-moraes)
For more information please contact Dr Isabel Moraes (Isabel.moraes@npl.co.uk)
To apply: http://careers.npl.co.uk/vacancies/

The UK`s National Physical Laboratory (NPL) is a public company funded by the UK BEIS department that sits at the intersection between scientific discovery and real world application as one of the world’s top three National Measurement Institutes.


[Post Date: January 16, 2018]
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