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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.

Title: Visiting Research Specialist

Description:
TItle: Visiting Research Specialist
Department: Department of Biological Sciences, University of Illinois at Chicago
Location: Chicago, Illinois, USA

Description: The Department of Biological Sciences, is recruiting a Visiting Research Specialist to Conduct research by using X-ray crystallography techniques to obtain structural basis for various functions of the bacterial ribosome and its inhibition by different small-molecule inhibitors. The successful candidate should have capabilities in molecular biology, biophysics, and X-ray crystallography methods, such as various molecular cloning techniques, protein chemistry techniques, as well as expert level of knowledge of the following software: XDS, HKL2000, Coot, PyMol, CCP4, Phenix, Adobe Illustrator, Adobe Premier. A track record of training junior researchers is highly desirable. The successful candidate would conduct his/her own research and assist with the principal investigator’s research, while training other laboratory personnel in various techniques, experiments and the appropriate use of research equipment. They would also perform data analysis and manage, document, and help with the dissemination of research activities for publication and outreach activities.

Duties:
• Perform research relevant to the assigned projects;
• Isolate and crystallize bacterial ribosomes;
• Purify all additional components necessary for the crystallization experiments, such as recombinant proteins, tRNAs;
• Collect X-ray diffraction data from the ribosome crystals at the APS Synchrotron;
• Perform data analysis; coordinate, analyze, and document results for publication;
• Directly participate in writing papers and grants based on the experimental data;
• Train undergraduate and graduate students in research methods, use of equipment, record keeping, and laboratory database entry;
• Attend weekly group meetings and journal clubs.

Qualifications:
• Bachelor’s degree in biological sciences required, Master’s degree or higher is preferred
• Minimum of 3 years of laboratory research experience is required
• Strong background in biochemistry and molecular biology is required.
• Experience in X-ray crystallography is not required but highly desirable
• Experience with molecular cloning and protein chemistry is highly desirable.
• Experience with bacterial ribosomes and bacterial translation systems.
• Successful candidate should be able to walk into the laboratory and be able start working without significant additional training in basic molecular biology techniques.


For fullest consideration please complete the on-line application and upload a resume by June 6, 2018 at https://jobs.uic.edu/job-board/job-details?jobID=95609&job=visiting-research-specialist-biological-sciences.

The University of Illinois at Chicago is an Equal Opportunity, Affirmative Action employer. Minorities, women, veterans and individuals with disabilities are encouraged to apply.

The University of Illinois may conduct background checks on all job candidates upon acceptance of a contingent offer. Background checks will be performed in compliance with the Fair Credit Reporting Act.


[Post Date: May 23, 2018]

Title: Postdoc Hauptman-Woodward MRI

Description:
Position description: A postdoctoral position at the Hauptman-Woodward Medical Research Institute (HWI) is offered in the laboratory of Dr. Aviv Paz, starting at the summer of 2018. We are seeking a highly motivated candidate that is passionate about solving structures and applying the structural insights gained for the understanding of biological processes. The main focus of the lab is the structure, function and dynamics of transmembrane transport proteins, and most of our effort is dedicated to the structural and functional characterization of structurally unresolved human transporters. In order to study these biomedically relevant and challenging targets we employ a vast array of structural-biology, biophysical and biochemical methods. The laboratory is part of the HWI and as such we enjoy access to the versatile equipment, expertise and facilities that the HWI has to offer (see https://hwi.buffalo.edu/facilities/). This position is fully funded but the successful candidate will be strongly encouraged to apply for independent funding.

Qualifications: The candidate must hold a Ph.D. degree, have a strong background in protein biochemistry or structural-biology and be the first author of at least one publication. Experience in protein expression, purification and biochemical characterization are required. Prior experience in the membrane protein field or mammalian expression systems (either yeast or cell-lines) is an added advantage.

To apply: Please send an e-mail to apaz@hwi.buffalo.edu and attach a short C.V. (2 pages max), a summary of previous research experience, and contact information of two references.


[Post Date: May 23, 2018]

Title: Beamline Scientist NSLS-II
Website: https://jobs.bnl.gov/job/upton/beamline-scientist-macromolecular-crystallography/3437/7918658

Description:
NSLS-II Beamline Scientist Position for macromolecular crystallography

We are recruiting a PhD-level beamline scientist to work at our MX
beamlines:
https://jobs.bnl.gov/job/upton/beamline-scientist-macromolecular-crystallography/3437/7918658

You can learn about our beamlines at this site:
https://www.bnl.gov/ps/lsbr/

The MX beamlines are really remarkable. FMX produces a 1.5 x 1.0 micron beam; AMX produces one that is 5 x 7 microns. Â We have crystal-changing automation working that takes less than one minute to change specimens. Typically one can do a low-dose grid scan to find well-diffracting regions; a 20 x 20 scan will take less than 10 seconds to measure, and the "heat map" appears within five seconds. Data collections (with an attenuated beam) typically operate at 100 Hz with 0.2 degree increments: 360 degrees in 18 seconds or 180 in 9. The detectors would go faster than this; prudence keeps us here.

This environment will stimulate the imagination of any experienced or early-career stage crystallographer. Please encourage promising, co-workers to apply.


[Post Date: May 21, 2018]

Title: Postdoc Francis Crick Institute
Website: http://bit.ly/2rTlaoj

Description:
A four-year postdoc position is available in the Signalling and Structural Biology Laboratory at the Francis Crick Institute, London, UK, focusing on cryoEM / X-ray crystallography of Rho-dependent protein kinases assemblies.

Candidates with experience in biochemistry and/or structural biology are particularly encouraged to apply.

Closing date for applications is 30th May 2018.

Informal enquiries may be made to Prof Neil McDonald
(neil.mcdonald@crick.ac.uk).

Applications can be made through the Crick HR platform here: http://bit.ly/2rTlaoj


[Post Date: May 18, 2018]

Title: Postdoc & Research Assistant Oxford University

Description:
We are looking for enthusiastic scientists interested in membrane proteins to join our multi-disciplinary team at the Structural Genomics Consortium Oxford.

We are working in close collaboration with several pharma partners and combine X-ray crystallography, single-particle cryo-electron microscopy and biophysical assays to understand the structure and function of human membrane proteins, including ion channels, transporters and enzymes.

The SGC has state-of-the-art facilities for high-throughput cloning, protein production, crystallization and regular access to the I24 microfocus beamline at Diamond Lightsource on Harwell Oxford Campus. Accessible cryo-EM facilities with several K2- or Falcon III-equipped Titan Krios, Talos Arctica and Glacios microscopes include the closely located Oxford Particle Imaging Centre (OPIC), the Central Oxford Structural Molecular Imaging Centre (COSMIC), and the Electron Bio-Imaging Centre (eBIC) on Harwell Campus.

We currently have two job opportunities:

Postdoc position (application deadline: June 13):

https://www.thesgc.org/careers/oxford/sgc-oxford-postdoctoral-scientist-%E2%80%93-membrane-protein-structure-and-function-group-0

Research Assistant position (application deadline: June 11):

https://www.thesgc.org/careers/oxford/sgc-oxford-research-assistant-membrane-proteins

For more information please visit: https://www.thesgc.org/groupprofile/15094 and https://www.thesgc.org/node/9500

or email katharina.duerr@sgc.ox.ac.uk

We are looking forward to receive your application!


[Post Date: May 17, 2018]

Title: Protein Crystallography Facility Manager
Website: https://mrc.tal.net/vx/appcentre-ext/candidate/post/1707/en-GB

Description:
Protein Crystallography Facility Manager, MRC Laboratory of Molecular Biology, Cambridge, UK

The MRC Laboratory of Molecular Biology (LMB) seeks to appoint a Protein Crystallography Facility Manager. The LMB is one of the birthplaces of structural biology and remains at the forefront of methods development as protein crystallography is a critical technique for understanding the mechanisms of macromolecular complexes, one of the major goals of the LMB. The post-holder will provide support to researchers from all Divisions of the LMB in the collection of X-ray diffraction data using both synchrotrons and in-house X-ray facilities, will maintain and develop the in-house facilities, will provide expert advice and support during subsequent structure determinations, and will act as the coordinator for LMB's synchrotron access. It is expected that there will be the opportunity for collaboration on structural projects with research groups at the LMB.

The successful applicant will have several years of post-doctoral experience in the field of protein crystallography including data collection at synchrotrons and all aspects of structure determination. Excellent communication and inter-personal skills are required because the post will involve interacting with a diverse range of scientists with different levels of expertise.

Closing date for applications: 11th June 2018

For further details and information on how to apply please visit:
https://mrc.tal.net/vx/appcentre-ext/candidate/post/1707/en-GB

Informal enquires should be addressed to
Dr. David Barford. E.mail: dbarford@mrc-lmb.cam.ac.uk
Dr. Jan Löwe. E.mail: jyl@mrc-lmb.cam.ac.uk


[Post Date: May 15, 2018]

Title: IT Specialist-Cryo-EM, Memphis, TN

Description:
The World’s Most Dedicated Never Give Up
There’s a reason St. Jude Children’s Research Hospital is consistently ranked on Fortune Magazine’s “100 Best Places to Work For” list. Because at our world-class pediatric research hospital, every one of our professionals shares our commitment to make a difference in the lives of the children we serve. There’s a unique bond when you’re part of a team that gives their all to advance the treatments and cures of pediatric catastrophic diseases. The result is a collaborative, positive environment where everyone, regardless of their role, receives the resources, support and encouragement to advance and grow their careers and be the force behind the cures.

IT Specialist-Cryo-EM
Memphis, TN

Overview
St. Jude is setting up a new, state-of-the-art cryoEM facility that will house a 300kV Titan Krios and a 200 kV Talos Arctica electron microscope, both equipped with a K3 direct electron detector and energy filter, for high resolution structural studies of biological molecules as well as a 120kV instrument for routine electron microscopy applications. The cryoEM facility will be supported by the newly established St. Jude Data Center, which houses a 6,400-core high performance computing facility.

We are seeking a highly motivated individual to join the team as a cryoEM IT scientist to support the mission of the facility in high resolution cryoEM. You will be responsible for installing, configuring, maintaining and overseeing computational resources in the cryoEM facility including software and hardware, troubleshooting, training and assisting users, participating in the development of new computational tools and methods in cryoEM, and performing other duties as assigned. Salary will be competitive and will be commensurate with experience of the candidate.

Responsibilities
• Installing, configuring, maintaining and overseeing computational resources in the cryoEM facility including software and hardware.
• Configuring and maintaining the on-line booking/logging system at the facility.
• Participating in and assisting cryoEM image processing workflow.
• Training, assisting and overseeing users in usage of computational resources.
• Developing and implementing new scripts, web interfaces, tools, approaches, and/or strategies to facilitate all aspects of cryoEM data handling to help advance cryoEM to atomic resolution.
• Work and collaborate with the IT team at the St. Jude Data Center on data processing, data transferring and data storage.
• Managing computational resources in the cryoEM facility, including, but not limited to, organizing the resources, ordering supplies, keeping records, writing reports, and other activities as assigned.

Minimum Experience
• Two (2) years of relevant experience required. CryoEM experience preferred
• Familiar with UNIX/Linux, CentOS;
• Experience in Python programing and shell scripting;
• Experience in high performance computing/Linux cluster is a plus;
• Strong motivation and ability to learn and practice new concepts/tools/techniques;
• Ability in working both independently and collaboratively as a team member;
• Excellent problem-solving skills;
• Strong oral and written skills;

Minimum Education
• A Bachelor's or Master's degree in Computer Science, or a PhD in biochemistry, biophysics, structural biology or a related field

Ready to join a team that stops at nothing, because we believe anything is possible?

Apply now at: https://bit.ly/2KgvJbU

St. Jude Children’s Research Hospital is an Equal Opportunity Employer. St. Jude does not discriminate on the basis of race, national origin, sex, genetic information, age, religion, disability, sexual orientation, gender identity, transgender status, veteran’s status or disabled veteran’s status with respect to employment opportunities. All qualified applicants will be considered for employment. St. Jude engages in affirmative action to increase employment opportunities for minorities, women, veterans and individuals with disabilities.


[Post Date: May 14, 2018]

Title: Cryo-EM Specialist, Memphis, TN
Website: https://bit.ly/2KbnOMI

Description:
The World’s Brightest Minds Always Innovate
At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big, and we give you everything you need to be the force behind our cures.

Overview
St. Jude is setting up a new, state-of-the-art cryoEM facility that will house a 300kV Titan Krios and a 200 kV Talos Arctica electron microscope, both equipped with a K3 direct electron detector and energy filter, for high resolution structural studies of biological molecules as well as a 120kV instrument for routine electron microscopy applications. The cryoEM facility will be supported by the newly established St. Jude Data Center, which houses a 6,400-core high performance computing facility.

We are seeking a highly motivated individual to join the team as a cryoEM scientist to support the mission of the facility in high resolution cryoEM. The successful candidate will be responsible for operating and maintaining those electron microscopes on the daily basis, training and assisting users, participating in development of cryoEM technology, and performing other duties as assigned. Salary will be competitive and will be commensurate with experience of the candidate.

Responsibilities
• Daily operation and maintenance of electron microscopes, serving as an interface to the electron microscope manufacture’s engineers to ensure optimal performance of the instruments;
• Operation and maintenance of cryoEM-related ancillary equipment such as Vitrobot, carbon coater, plasma cleaner, etc.
• Sample preparation with FEI Vitrobot and manual plunger-freezer;
• CryoEM image collection;
• Training, assisting and overseeing users in sample preparation and data collection;
• Managing the cryoEM facility, including, but not limited to organizing the labs, ordering supplies, keeping records, writing reports, and other activities as assigned;
• Developing and implementing efficient strategies for sample preparation and data collection;
• Participating in development and implementation of new methods/techniques in cryoEM;

Minimum Experience
• A minimum of 2-5 years of experience in cryoEM analysis of biological molecules;
• Hands-on experience in operation of electron microscopes for image collection;
• Hands-on experience in operation of Vitrobot, manual plunger and/or other related equipment in biological electron microscopy;
• Experience in high resolution cryoEM;
• Hands-on experience in usage of cryoEM software such as Leginon for automated image collection;
• Hands-on experience in operation of Titan Krios and Talos Arctica;
• Experience in cryo electron tomography a plus;
• Skills in working and communicating with scientists at all levels;
• Ability in working on multiple challenging tasks in a rapidly-paced environment.
• A strong publication record;
Minimum Education
• A PhD in biochemistry, biophysics, structural biology or a related field

Ready to join a team that is always innovating, because we believe anything is possible?

Apply now at: https://bit.ly/2KbnOMI

St. Jude Children’s Research Hospital is an Equal Opportunity Employer. St. Jude does not discriminate on the basis of race, national origin, sex, genetic information, age, religion, disability, sexual orientation, gender identity, transgender status, veteran’s status or disabled veteran’s status with respect to employment opportunities. All qualified applicants will be considered for employment. St. Jude engages in affirmative action to increase employment opportunities for minorities, women, veterans and individuals with disabilities.


[Post Date: May 14, 2018]

Title: Senior Scientist Lonza Biologics
Website: https://lonza.wd3.myworkdayjobs.com/en-US/Lonza_Careers/job/Cambridge/Senior-Scientist_R8148

Description:
Job Description Summary

Here at Lonza we have a great opportunity available for a Senior Scientist to join Lonza's Applied Protein Services (APS) Bioinformatics team. This is a permanent position based out of our Cambridge facility.

The Senior Scientist will work on multiple customer projects including antibody and protein engineering and design, antibody humanisation and deimmunisation and immunogenicity and protein risk assessments. In addition, the role will involve some system administration and programming to support the maintenance and development of multiple proprietary platforms.

Key Responsibilities:

To perform computational antibody and protein engineering to design and/or modify potential biotherapeutics for customers

To perform in silico:

antibody humanisation and deimmunisation

immunogenicity risk assessments using Lonza’s proprietary EpibaseTM T-cell epitope prediction platform

developability risk assessments and antibody aggregation risk prediction using Lonza’s proprietary platforms

To perform expert sequence and structure based risk assessments

Program/script to support the development and maintenance of proprietary platforms and algorithms

Work in both Linux and Windows environments

To author high quality reports for clients and in-house development work

Share responsibility for maintenance and update of software, databases, systems and servers

To communicate project updates to internal and external clients

Interested?

What we need you to have:

PhD or equivalent experience in Bioinformatics/Structural Biology with a focus on computational protein engineering and modelling , preferably with experience in industry

Demonstrate attention to detail and ensure that quality standards are maintained while delivering results


[Post Date: May 14, 2018]

Title: Postdoc NIH

Description:
Cell Biology and Biophysics Unit, National Institutes of Health, Bethesda, USA
A postdoctoral fellowship opportunity is available in the Cell Biology and Biophysics Unit headed by Dr. Antonina Roll-Mecak to work on structural and functional studies of tubulin modification enzymes and molecular motors using a combination of X-ray crystallography, cryo-EM and single molecule fluorescence microscopy. Research in the Roll-Mecak lab focuses on deciphering the tubulin code ie how tubulin posttranslational modifications tune microtubule functions (see for instance Garnham et al., Cell 2015, Valenstein et al., Cell 2016, Vemu et al., JBC 2016; Zehr et al Nature Struct & Molec Biology, 2017). We use a combination of biochemistry, X-ray crystallography, electron microscopy and single-molecule fluorescence techniques. For more information about the lab please visit: https://neuroscience.nih.gov/ninds/rm_lab/

I am looking for enthusiastic, self-motivated Ph.D. graduates with a strong publication record and expertise in molecular biology, biochemistry, X-ray crystallography or electron microscopy who welcome working in an interdisciplinary group with a supportive atmosphere and excellent resources. The Washington DC area is a great place to live with great access to cultural and outdoor activities. Experience with assembly of large protein complexes or structure determination by crystallographic methods or EM is a definite plus. The successful applicant will be awarded a NINDS Intramural Fellowship. Please send a CV, a one-page research experience summary and contact information of three references to Antonina@mail.nih.gov Please write “Fellow - tubulin code” in the subject header.


[Post Date: May 10, 2018]

Title: Postdoc NIH

Description:
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT, BETHESDA, MD AND SURROUNDING AREA

Position Description:
The research group of Dr. Anirban Banerjee at the National Institutes of Health (NIH) is seeking candidates for postdoctoral fellows . The broad interests of the lab are in membrane protein structure and function. We combine structural techniques such as macromolecular crystallography and cryo EM with biophysical and biochemical methods such as reconstitution based assays, high resolution light microscopy and small molecule screening to investigate the structural bases of the mechanisms of a number of membrane proteins.

The lab has state-of-the-art equipment and facilities. We have dedicated periodic access to the 22-ID beamline at the APS, for crystallographers at the NIH, as well as access to 23-ID and 24-ID beam lines at the APS. Our laboratory is part of the Cell Biology and Neurobiology Branch in the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). We also have an affiliation to the National Institute of Neurological Disorders and Stroke (NINDS).

Qualifications:
The candidates should hold a Ph.D. degree, be author of at least one first author publication and have a strong background in biochemistry or structural biology. Experience with basic molecular biology, protein expression, purification and biochemical characterization are required. Prior experience in membrane protein biochemistry or mammalian expression system for protein purification will be added advantages.

It is absolutely essential the candidate is motivated and prepared to put in the best efforts for fruition of the project goals. We are a small, friendly lab and ability to work as part of a cohesive group is important.

To Apply:
Interested candidates can send an e-mail to anirban.banerjee@nih.gov with a CV and a summary of previous research experience and future interests.

The NIH is dedicated to building a diverse community in its training and employment programs.



[Post Date: May 10, 2018]

Title: Postdoc Queen Mary University London
Website: https://webapps2.is.qmul.ac.uk/jobs/job.action?jobID=3305

Description:
Applications are invited for a Postdoctoral Research Assistant to work in the research group of Dr James Garnett at Queen Mary University London (QMUL). This appointment is funded by the MRCt for 36 months.
The appointee will study several type-II secreted substrates/effectors from Legionella pneumophila and dissect the mechanisms by which they are targeted to bacterial and host membranes and their specific functions at these sites. The work will involve using structural biology techniques and functional in vitro/cellular assays to characterise their role during L. pneumophila pathogenesis.

Previous experience in X-ray crystallography is essential and experience with other structural biology techniques (e.g. cry-EM, NMR and/or SAXS) is also desirable.

Closing date for applications: 31st May 2018

For full details and how to apply:
https://webapps2.is.qmul.ac.uk/jobs/job.action?jobID=3305

For informal general discussion regarding the post, please contact Dr Alessandro Pandini via email: j.garnett@qmul.ac.uk


[Post Date: May 07, 2018]

Title: Postdoc EMBL Heidelberg
Website: http://www.embl.org/jobs

Description:
The European Molecular Biology Laboratory (EMBL) is a world leading international research organization pursuing interdisciplinary research in the Life Sciences (www.embl.de). The Headquarters Laboratory is located in Heidelberg (Germany), with additional sites in Grenoble (France), Hamburg (Germany), Hinxton (UK) and Monterotondo (Italy).

A fully funded postdoctoral position is available in the Barabas Group in Heidelberg. The group studies mobile genetic elements using structural, biochemical and cell biology approaches. We strive to learn how these “jumping genes” move between genomic locations, and how they integrate in the life-cycle of their host organisms and ecosystems (e.g. Rubio-Cosials et al. Cell 2018). Building on structure-function relationships, we further develop tools for genetic engineering (Voigt et al. Nat Commun. 2016).

Transposons comprise much of modern genomes, but their mechanisms and physiological roles are poorly understood. While DNA repair pathways safeguard genome stability, mobile genetic elements keep changing genomic sequence and expression profile driving evolution, adaptation and genetic diversity. In this project, we aim to elucidate how transposons liaise with their host to impart genome plasticity without harming the host.

We seek a skilled and passionate biochemist or structural biologist to study the cooperation of transposons with the DNA repair machineries in their host. The work will include protein-nucleic acid biochemisty, structural biology (X-ray crystallography and cryoEM), cell biology, microscopy, and/or bioinformatics approaches. This project is part of a DFG-funded collaboration with the Bétermier lab (I2BC, CNRS, France), providing the opportunity for extensive interdisciplinary interactions.

The postdoctoral fellow will have access to world-class structural biology, proteomics, genomics, and microscopy facilities at EMBL and will be offered expert training in relevant experimental techniques. After initial training, he/she will be expected to work independently, while well integrated into a highly collaborative team. For more information, you may contact Dr. Barabas per e-mail. Researchers interested in working on other projects in the group should also write to Dr. Barabas directly. https://www.embl.de//research/units/scb/barabas/index.html


[Post Date: May 04, 2018]

Title: Postdoc UTMB

Description:
Post-doc position at University of Texas Medical Branch (UTMB), TX, USA

Postdoctoral positions in structural biology are available in Dr. Kay Choi's laboratory at the University of Texas Medical Branch (UTMB) to participate in virus replication projects. We use a combination of X-ray crystallography, cryo-electron microscopy (cryo-EM), and biochemistry to investigate the structure and mechanism of viral macromolecular complexes. Experience in either X-ray crystallography, cryo-EM or biochemistry is required. For more information please see ‘https://bmb.utmb.edu/faculty/choi.asp’

The X-ray crystallography resources at UTMB include two X-ray area detector systems, a Phoenix crystallization robot, a Minstrel crystal imaging robot, and an Alchemist liquid handling robot. The cryo-EM includes two JOEL 200 keV cryo-EM microscopes for high-resolution imaging work, an FEI vitrobot, and a BSL-3 room for viral and pathogen work. For more information, please see ‘https://scsb.utmb.edu/resources/default.asp’

Interested parties should send a cover letter, CV and a list of 2-3 references to Dr. Kay Choi via e-mail at kychoi@utmb.edu.


[Post Date: May 02, 2018]

Title: Postdoc University of Cambridge
Website: http://www.jobs.cam.ac.uk/job/17208/

Description:
A postdoctoral position is available to work on a Wellcome Trust funded project to investigate the molecular mechanisms of regulation of alternative pre-mRNA splicing in the group of Prof. Chris Smith (https://www.bioc.cam.ac.uk/research/uto/smithc).

The position will be based in the University of Cambridge, Department of Biochemistry, Tennis Court Road, Central Cambridge. The project focuses on the mechanisms by which regulatory RNA binding proteins control splicing complex assembly at regulated splice sites, and builds upon our recent discovery of a master splicing regulator that acts in smooth muscle cells. It will involve a range of biochemical, molecular, proteomic, biophysical, structural and single-molecule techniques based in the PI's and collaborators labs. We need to recruit someone with expertise in structural biology (X-ray crystallography, Cryo-EM) and associated biophysical techniques to complement our established expertise in RNA molecular biology. Prior knowledge or experience of RNA splicing, RNA biology or nucleic acid-protein assemblies would be an advantage. The funds for this post are available for 5 years in the first instance.


[Post Date: April 26, 2018]

Title: Postdoc University of British Columbia

Description:
Postdoctoral position - Membrane protein Biochemist

We are looking for a protein biochemist to join our team. We are investigating the structure and function of ion channels, membrane proteins that generate electrical signals in excitable cells. They are targets for disease mutations linked to cardiac arrhythmia, epilepsy, myopathies, and much more. We combine high-resolution techniques (X-ray crystallography, cryo-EM) with functional methods (calorimetry, electrophysiology) to obtain a complete understanding of their function.

Our institute is equipped with state-of-the-art equipment for structural biology, including a new Titan Krios microscope with FalconIII detector and Volta phase plate, Vitrobots and screening microscopes (Tecnai Spirit and F20), 2 Rigaku 007 instruments for X-ray diffraction, and various robotics for setting up and visualizing crystallization screens.

Your profile:

* A recent PhD (obtained within the last 4 years)

* Experience with structural biology (NMR, X-ray Crystallography or cryo-EM).

However, applicants with excellent skills in membrane protein expression and purification, especially in mammalian or insect cell lines, are also encouraged to apply.


For more info about our research program, please visit our website:
http://crg.ubc.ca/VanPetegem/

The position is available immediately and remains open until filled.
Interested applicants can send their CV, a cover letter, and names + contact details of 3 references to: Filip.vanpetegem@gmail.com


[Post Date: April 25, 2018]

Title: Postdoc KU Leuven, Belgium

Description:
Structural Biology lab of Kalyan Das, Rega Institute (https://rega.kuleuven.be/labs), KU Leuven (https://www.kuleuven.be/english/research/about_research/index), Belgium invites applications from highly motivated researchers interested in perusing carrier in structure-based drug design. The successful candidate will be carrying out structural studies using crystallography and/or single-particle cryo-EM, and will work in a multi-disciplinary environment.

A candidate should have a Ph. D. degree in structural biology, molecular biology, chemical biology, biochemistry, or a related subject. Strong background in molecular cloning, protein expression systems, and protein purification is essential. Structural studies by X-ray crystallography and/or single particle cryo-EM experience is desirable. A qualified person should be a team player, and should have strong writing and verbal communication skills.

The lab is equipped with Akta Pure, Wyatt miniDAWN TREOS and DynoPro NanoStar, GelDoc EZ, TTP mosquito crystallization robot with LCP dispenser and humidity chamber, JANSi UVEX microscope + cytomat II for robotic screening of crystallization plates under UV and bright field, Leica EM GP, GPU workstations etc.
Rega Institute/KU Leuven provides a unique multi-disciplinary translational research platform, expertise and cutting-edge research facilities for drug discovery.
Interested candidates are encouraged to email their resume, list of publications, and names and addresses of three referees to Kalyan Das (E-mail: kalyan.das@kuleuven.be), Professor, Division of Virology and Chemotherapy, Rega Institute.


[Post Date: April 22, 2018]

Title: Postdoc University of Chicago

Description:
Postdoctoral Position in Cellular Communication

Applications are invited for an immediate opening at the Cellular Communication Group with Dr. Demet Araç, at the Department of Biochemistry and Molecular Biology, University of Chicago (http://arac.uchicago.edu).

We are interested in understanding how cellular communication in the nervous system is mediated by adhesion molecules on cell surfaces and how cell-cell interactions regulate cellular signaling at the molecular level. The following papers describe the current direction of our research program:

· Structural basis for teneurin function in circuit-wiring: A toxin motif at the synapse. Li, Shalev-Benami, Sando,…, Südhof, Skiniotis, Araç. Cell (2018)
· Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region. Salzman, Zhang, …, Koide, Araç. PNAS (2017)
· Structural basis for regulation of GPR56/ADGRG1 by its alternatively spliced extracellular domains. Salzman, Ackerman , … , Koide, Araç. Neuron (2016)
· Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Lu, Nazarko, … , Südhof, Araç. Structure (2015)

Applications from a range of backgrounds including biochemistry, molecular biology, and cell biology are invited. Required skills include cell culture, molecular cloning and protein biochemistry. Experience in protein expression/purification, structure determination, and GPCR signaling pathways are a plus.

Our laboratory is located at the University of Chicago, and is affiliated with the Department of Biochemistry and Molecular biology (http://bmb.uchospitals.edu/) and the Grossman Institute for Neuroscience, Quantitative Biology and Human Behavior (http://neuroscience.uchicago.edu/grossman-institute/). The researcher recruited through this project will have the opportunity to visit and collaborate with interdisciplinary scientists on campus (https://www.uchicago.edu/).

Highly motivated candidates with a strong track record of publications should send an application package with research interests, full CV with experimental skills listed in detail, names and contact information of 3 references to Demet Araç (arac AT uchicago.edu).

The University of Chicago is an Affirmative Action/Equal Opportunity/Disabled/Veterans Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran status or status as an individual with disability.


[Post Date: April 20, 2018]

Title: Postdoc University of California, Irvine

Description:
One postdoctoral position is available in Dr. Rongsheng Jin’s laboratory at the Department of Physiology and Biophysics, University of California Irvine (Irvine, California, USA). The new postdoctoral fellow is expected to participate in NIH-supported projects focusing on the mechanism of action of bacterial virulence factors in their cellular context (Science 2012, PLOS Pathogens 2013, Science 2014, NSMB 2016, Science 2018). Our laboratory employs a multidisciplinary approach that combines X-ray crystallography, SAXS, electron microscopy with the more traditional approaches of biochemistry and biophysics. We have also built long-standing collaborative relationships in the areas of cell biology, electrophysiology, toxicology, and animal studies. The successful candidates should have a Ph.D. degree, high motivation, and strong background in one or more of the following research areas: biochemistry, biophysics, molecular biology and structural biology. Applicants please send their curriculum vitae and names of three referees to r.jin@uci.edu.

[Post Date: April 19, 2018]
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