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Crystallography related career opportunities, post docs and related positions in the crystallography community. If you wish to place your job opportunity on the Hampton Research website, submit the details to tech@hrmail.com.

Title: Research Technician

Description:
Applications are invited for a full-time Research Technician position at the Membrane Protein Laboratory (MPL) located at the Diamond Light Source and at the Research Complex (Oxfordshire).

The MPL is Wellcome Trust funded facility created to allow scientists to determine medically relevant membrane protein structures more efficiently by combining recently developed high throughput technologies for protein production, crystallization, XFEL and EM. The MPL is located in laboratories around the ring at Diamond and also at the Research Complex at Harwell and equipped with state-of-the-art equipment.

The successful applicant will report directly to Dr Isabel Moraes, the MPL Group Leader. In the group he/she would assist in all aspects of the lab work, in particular repair and maintenance of crystallisation robots, assisting with training users in crystallisation with robots; production and crystallisation of membrane proteins. The technician will also be responsible for the general running of the laboratory, including placing orders, maintaining stocks of chemicals, preparing solutions, maintaining all the equipment and general laboratory maintenance. The applicant will also have a role in maintaining safety standards and documentation and have excellent communication skills.

For further details about the position and how to apply please visit http://www.diamond.ac.uk/Careers/Vacancies/All/028_17_CH.html


Informal enquiries may be made to Dr Isabel Moraes, the MPL group leader Isabel.de-moraes@diamond.ac.uk


[Post Date: April 21, 2017]

Title: Research Assistant

Description:
Applications are invited for a full-time Research Assistant position at the Membrane Protein Laboratory (MPL) located at the Diamond Light Source and at the Research Complex (Oxfordshire).

The MPL is Wellcome Trust funded facility created to allow scientists to determine medically relevant membrane protein structures more efficiently by combining recently developed high throughput technologies for protein production, crystallization, XFEL and EM. The MPL is located in laboratories around the ring at Diamond and also at the Research Complex at Harwell and equipped with state-of-the-art equipment.

The successful applicant will report directly to Dr Isabel Moraes, the MPL Group Leader. In the group he/she will primarily assist the MPL users with molecular biology (cloning), expression in insect cell and mammalian, protein purification and/or crystallisation. In addition, the post holder should be familiar with all the facility equipment and also be involved in the in the day-to-day running of the laboratory, including equipment maintenance, ordering and health and safety procedures (Risk Assessments, GM forms and COOSH). The person will also be involved in sample preparation for EM and XFEL applications.

The successful candidate should have a Masters degree in biological sciences, or the equivalent in professional qualifications. In addition to good English verbal and written communication skills, methodical approaches to work and the ability to pay close attention to details is also desired. You will also have good interpersonal and organisational skills as well as the ability to work as part of a team.

For further details about the position and how to apply please visit http://www.diamond.ac.uk/Careers/Vacancies/All/027_17_CH.html


Informal enquiries may be made to Dr Isabel Moraes, the MPL group leader Isabel.de-moraes@diamond.ac.uk


[Post Date: April 21, 2017]

Title: Postdoc UC Riverside

Description:
A post-doctoral position is immediately available for highly motivated, hard-working candidates to join Dr. Jikui Song’s group in the Department of Biochemistry at University of California, Riverside. Dr. Song’s research group employs collaborative and multidisciplinary approaches to investigate mechanistic basis of cancer epigenetics, in particular chromatin modifications that are essential for gene regulation and cell development. The project will involve structural and dynamic characterization of macromolecular complexes involved in epigenetic programming, using combined biochemical approaches, including X-ray crystallography, Cryo-electron microscopy, Single-molecule FRET and NMR spectroscopy. Applicants should hold a recent PhD degree and have significant experience in molecular cloning, protein production and protein biochemistry. Additional background in X-ray crystallography, NMR spectroscopy or enzymatic assay is considered a plus but not essential. Interested applicants should send curriculum vitae and contact information of 2-3 references to Jikui Song, Ph.D. Department of Biochemistry, University of California, Riverside, CA 92521 (Email: jikui.song@ucr.edu).

As one of the prestigious public universities in US, UC Riverside is located at the sunny southern California, near to big cities such as Los Angeles, San Diego and Las Vegas. Such an environment allows one to have a good balance of life and science here.

More information can be found in http://biochemistry.ucr.edu/faculty/song/song.html.


[Post Date: April 20, 2017]

Title: Postdoc CSHL

Description:
Postdoctoral position in membrane protein structural biology and electrophysiology

The laboratory of Hiro Furukawa at Cold Spring Harbor Laboratory (CSHL) is seeking an enthusiastic postdoc (NIH funded) with dynamic interests in solving questions in neuropharmacology using biochemical and biophysical techniques. We conduct structural biology (cryo-EM and x-ray crystallography) on transmembrane proteins to understand basic mechanisms of ion and substrate transport and on fragments of water soluble domains to answer specific pharmacological questions. We use diverse techniques to address protein functions including electrophysiology (two-electrode voltage clamp/patch-clamp/bilayer), imaging, calorimetry, and phage-display. We also attempt to understand critical protein-protein interactions in signal transduction cascades in neurons using a combination of proteomics, cryo-EM, and x-ray crystallography. CSHL will be equipped with Titan-Krios/K2 detector this summer. Importantly, it offers a unique scientific environment to interact with scientists within the institute as well as from outside at the prestigious CSHL courses and meetings (including the famous 2-week course, “X-ray Methods in Structural Biology” and the newly installed cryo-EM course). A desired candidate should hold or soon expected to hold (within ~0.5yr) Ph.D. in the area of cryo-EM, x-ray crystallography, or electrophysiology (biophysics). Please visit and see the lab website (http://furukawalab.labsites.cshl.edu/) before you apply and send CV with a brief research statement as well as 2-3 contacts for references to furukawa@cshl.edu.


[Post Date: April 20, 2017]

Title: Postdoc Oulu, Finland

Description:
We have an opening for a post-doctoral scientist in my research group at the Faculty of Biochemistry and Molecular Medicine, University of Oulu, Finland. The project focuses on structural analyses of myelin membrane proteins and the formation of proteolipid multilayers.

For more details about the position and the environment, please see the full advert:
https://rekry.saima.fi/certiahome/open_job_view.html?did=5600&jc=1&id=00003654&lang=en

Applications must be submitted through the online system, and applications sent by email will NOT be considered.


[Post Date: April 20, 2017]

Title: Postdoc EMBL Heidelberg

Description:
We are seeking to recruit a postdoctoral fellow for the structural and biochemical characterization of eukaryotic transcription complexes by X-ray crystallography or electron microscopy (single-particle cryo-EM and/or cryo-electron tomography). The successful candidate will join the group of Christoph Müller, Structural and Computational Biology Unit, at EMBL Heidelberg. EMBL is a leading international research organization with a collaborative and interdisciplinary atmosphere (see www.embl.de).

The cryo-EM facilities at EMBL are outstanding and soon house two FEI Titan Krios, a Talos Arctica and Polara equipped with state-of-the-art direct electron detectors. The Müller group studies molecular mechanisms of eukaryotic transcriptional regulation as also described at http://www.embl.de/research/units/scb/mueller_christoph/index.html.

The successful candidate holds a Ph.D. in structural biology or biochemistry. The position is particular suitable for an experienced protein crystallographer who is interested in moving into cryo-EM or an electron microscopist with experience in single-particle cryo-EM and/or cryo-ET. The position requires exceptional motivation and commitment, the ability to work independently as well as in a team and excellent technical, organizational and management skills. Further details regarding work in the laboratory and details of the projects can be directly obtained from Christoph W. Müller (cmueller@embl.de). EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation.

Closing date: 14 May 2017. Please apply online through http://www.embl.org/jobs


[Post Date: April 20, 2017]

Title: Experimental & Computational Postdocs

Description:
Experimental and Computational Postdoctoral Research Fellow Positions at Institute of Glycomics, Griffith University, Gold Coast, Australia

Prof Yaoqi Zhou’s group (http://sparks-lab.org ) is building up a strong term for his molecular biology laboratory to interact with his computational structural biology laboratory at the Institute for Glycomics, Griffith University, Gold Coast, Australia. Initial exciting discovery in protein expression optimisation, antibiotic and cancer inhibitor discovery and protein design leads to the current expansion of the team. We are seeking highly qualified and motivated Postdoctoral Research Fellows (One computational and one experimental) who share a passion for scientific discovery to work in the area of RNA/protein structure/function prediction and novel techniques for protein expression optimisation in various host cells, and novel anti-cancer, anti-bacterial and anti-viral inhibitor discovery based on in-house designed proteins and peptides.

More details and one-line applicattion can be found at:
https://ps-jobs.griffith.edu.au/psp/CAREERS/EMPLOYEE/HRMS/c/HRS_HRAM.HRS_APP_SCHJOB.GBL?Page=HRS_APP_SCHJOB&Action=U&FOCUS=Applicant&SiteId=100

Job ID is 105066 for experimental and 105077 for computational.


[Post Date: April 20, 2017]

Title: Postdoc Rice University

Description:
An NIH-funded postdoctoral opening is immediately available in the laboratory of Dr. Yizhi Jane Tao at Rice University, Houston, TX, USA. The project is to study RNA virus structure and function using X-ray crystallography, electron microscopy, and other biochemical/biophysical methods. Successful applicants are expected to be highly motivated individuals with a Ph.D. in biochemistry or structural biology.

Our laboratory is equipped with excellent biochemistry and molecular biology facilities. There is a in-house X-ray diffraction facility together with two crystal screening robots. We have regular access to synchrotron radiation at the APS, and there are several electron microscopes on campus for shared use.

Rice University is a private institution located right next to the Texas Medical Center, the home of 47 institutions including Texas Children’s Hospital, MD Anderson Cancer Center and the Baylor College of Medicine. There is a large structural biology community in Houston that is both intellectually stimulating and supportive.
Please send inquiries and applications to ytao@rice.edu. I will be happy to discuss with you about the details of the projects.


[Post Date: April 19, 2017]

Title: Postdoc MRC Laboratory of Molecular Biology

Description:
Postdoctoral Research Position in Structural Biology of Phosphoinositide Signaling

The mechanistic Target of Rapamycin (mTOR) is involved in sensing amino-acid availability, oxygen, ATP levels and growth-factor signalling. Its activity coordinates mRNA translation, lipid metabolism, mitochondrial functions, ribosome biogenesis and autophagy. The Ragulator and Rhebulator complexes control mTORC1 through two types of small GTPases, the Rags and Rheb. The three-year Cancer Research UK funded position focuses on the structural biology of mTORC1 assembled with its regulators on lysosomal membranes.

The research group of Roger Williams in the MRC Laboratory of Molecular Biology has an opening for a Postdoctoral Scientist to carry out structural and functional studies of mTOR-containing complexes. The programme involves cryo-electron microscopy, X-ray crystallography, H/D exchange mass spectrometry, as well as other biophysical and biochemical approaches.

Applicants should have a PhD in a relevant subject (e.g., biology, chemistry, biochemistry, or physics) or, exceptionally, equivalent experience. Applicants should also have a strong interest in structure-function studies of protein complexes. Experience in electron microscopy, crystallography or mass spectrometry is desirable.

The successful applicant will be awarded a 3 year Career Development Fellowship/MRC Postdoctoral Training Scheme. The fellowship is a training and development position for a Postdoctoral Scientist who has recently completed their doctoral studies, or is moving into a new research discipline.
Working for the MRC provides a whole host of benefits including a final salary pension scheme, Benenden Healthcare membership and excellent holiday entitlement. You will also have access to employee shopping/travel discounts, on site sport and social facilities, as well as salary sacrifice cycle to work schemes and childcare vouchers.

The MRC Laboratory of Molecular Biology is one of the birthplaces of molecular biology and is an internationally renowned centre for fundamental biomedical research. The LMB has an excellent record of innovative basic research leading to applications in medicine. Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.

For further information of the research undertaken at the LMB, please visit:
http://www2.mrc-lmb.cam.ac.uk or write to Roger Williams (rlw@mrc-lmb.cam.ac.uk)
To apply and access full details of the vacancy please visit our job board at https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/573. If you are unable to apply online please contact us at hradmin@mrc-lmb.cam.ac.uk .

Closing date: 7th May 2017

Final appointments will be subject to a pre-employment screening.

The Medical Research Council is an Equal Opportunities Employer who participates in the Disability Confident scheme


[Post Date: April 18, 2017]

Title: Postdoc Pfizer Research Laboratories

Description:
Applications are invited for post-doctoral positions in my group at Pfizer’s Research Laboratories in Groton CT. Please see the advertisements posted on LinkedIn:

https://www.linkedin.com/jobs/view/295904458/ and

https://www.linkedin.com/jobs/view/290461069/

Positions are available for highly motivated, outstanding applicants with a recent Ph.D and experience in protein crystallography, biochemistry and molecular biology, and an interest in working in a drug discovery group. You will work as part of a highly interdisciplinary structural biology and biophysics group with expertise in protein crystallography, protein NMR, cryo-electron microscopy, advanced biophysical and biochemical techniques and molecular biology, all working towards the goal of discovering new human therapeutics.

Groton is located on the Connecticut shoreline, almost exactly midway between New York and Boston.

Please send your resume through the links to the company website provided in the advertisements.


[Post Date: April 14, 2017]

Title: Postdoc Brookhaven National Laboratory

Description:
The Quantitative Plant Science Initiative at Brookhaven National Laboratory in New York is seeking exceptional candidates for two post-doctorate associate positions with strong backgrounds in structural biology. The successful candidates will join a multi-disciplinary team dedicated to closing knowledge gaps in plant protein function while leveraging state-of-the-art capabilities at NSLS-II, the world’s brightest source of synchrotron light.

Potential projects range from metal ion transport and trafficking to photosynthesis to proteins of unknown function.

Please see Job ID #: 992 at the BNL career portal https://www.bnl.gov/hr/careers/jobs/index.php?q=1 for more information and to apply.


[Post Date: April 12, 2017]

Title: Postdoc University of Bristol
Website: http://tinyurl.com/kbxnhzm

Description:
Up to two Research Associate positions in cellular structural biology of transcription factors are available immediately in the Berger lab, University of Bristol UK, funded by the Wellcome Trust.

As part of a dynamic interdisciplinary team, the Research Associates will perform international leading basic research with the objective of unlocking the structure, function and cellular assembly of key eukaryotic transcription factor complexes, applying and integrating recombinant multiprotein expression tools, structural biology (X-ray, EM), biophysics, proteomics, cell biology and biochemistry techniques. Experience with recombinant expression of multiprotein complexes, structural biology methods (X-ray, EM) and cell biology techniques are highly desirable.Experience with complex multicomponent human transcription factors is a plus.

Applicants should hold, or expect to hold shortly, a PhD in biochemistry, molecular biology, structural biology (X-ray, EM) or a related subject.
The Research Associates will benefit from the cutting-edge Bristol Biosuite for structural biology and the Synthetic Biology centre (BrisSynbio, www.bristol.ac.uk/brissynbio/) and synergize with our internationally leading academic collaborators (Laszlo Tora, IGBMC; Patrick Schultz, IGBMC; Marc Timmers, Utrecht; Christiane Schaffitzel, Bristol; and Juri Rappsilber, Berlin).

For informal enquires please contact: Prof. Imre Berger 0044 117 39 41857, imre.berger@bristol.ac.uk

Closing date for applications is midnight Monday 1 May 2017.

For details follow link:
http://www.bristol.ac.uk/jobs/find/details.html?nPostingID=5805&nPostingTargetID=22027&option=28&sort=DESC&respnr=1&ID=Q50FK026203F3VBQBV7V77V83&JobNum=ACAD102543&Resultsperpage=10&lg=UK&mask=uobex


[Post Date: April 12, 2017]

Title: Project Manager in Crystallography

Description:
Start of contract: July 1, 2017

Type of contract: Permanent

Employer: NovAliX is a French contract research organization of 120+ employees providing expert driven innovative outsourcing and insourcing research services for drug discovery. NovAliX offers to the pharmaceutical industry a complete range of services spanning Biophysics, structural Biology, Chemistry & Drug Discovery. The position is based in Saclay, Essonne (South of Paris-France).

Job Description: You will join our 5-membered structural biology insourced team located on the Synchrotron SOLEIL to manage projects for our client in the field of structural biology. Your work will consist in:
- Conducting crystallographic projects from bibliographic work to structure determination, as well as project follow-up, clients reporting, drafting procedures and/or reports.
- Managing and supervising a team of research associates.
You will be in charge of protein production and purification from different expression systems, X-ray diffraction data collection & processing, structure determination of proteins of interest and of protein-ligand complexes.

Profile: You should have a PhD in crystallography with ca. 4-6 years of experience in modern Crystallography techniques (preferentially experienced in the life science industry) during which you have deepened and widened your practical and theoretical knowledge in the field of construct design, protein biochemistry and crystallography. A good knowledge of software packages employed in protein crystallography is a must. Additional experience in molecular biology and/or insect cells culture and characterization of protein/ligand complexes would be an asset.

We are seeking a person who speaks fluently English and French, who is passionate about structural biology and who has a keen sense of responsibility as well as being a committed team player. The candidate will have a rigorous and organized attitude to work with excellent supervisory and reporting skills.

Please send your questions/application in English (CV, research work, references) only by email to: poste15@novalix-pharma.com

NovAliX, BioParc, Boulevard Sébastien Brant, BP30170, F-67405 Illkirch CEDEX
Tel : +33 (0) 368 330 200 - Fax : +33 (0) 368 330 201 - Email : info@novalix-pharma.com


[Post Date: April 12, 2017]

Title: Postdoc University of Sussex

Description:
Two post-doctoral positions are available in the laboratories of Dr Antony Oliver and Dr Jo Murray, at the Genome Damage and Stability Centre, University of Sussex, UK.
Both positions are MRC-funded for a period of 3 years, and will study how interactions of the Smc5/6 complex with DNA governs its roles in replication and recombination.

The first post would someone with a strong structural biology background, whilst the second someone with extensive experience in biochemistry/biophysics/cell biology.

More details (including how to apply and eligibility conditions) can be found at the following URLs:
http://www.sussex.ac.uk/about/jobs/research-fellow-1990 (Structural Biology)
http://www.sussex.ac.uk/about/jobs/research-fellow-1991 (Biochemistry)

CLOSING DATE = 19 May 2017

Additional information may also be found at:
http://www.sussex.ac.uk/gdsc/researchgroups
http://www.sussex.ac.uk/gdsc/
http://www.sussex.ac.uk/lifesci/


[Post Date: April 12, 2017]

Title: Postdoc RNA-Protein Interactions

Description:
We are looking for a researcher to explore the druggability of RNA-protein interactions with small molecule compounds. The successful candidate will identify and characterize novel, disease-implicated RNA-protein interactions, establishing and conducting assays to target those interactions pharmacologically.

This project is a collaboration between Cellzome-GSK and two leading research groups in the field of RNA-protein interaction: the group of Matthias Hentze (EMBL-Heidelberg) and the group of Marco Marcia (EMBL Grenoble).

This project offers the opportunity to work in multi-disciplinary, international teams in Heidelberg-Germany (Cellzome and EMBL) and in Grenoble, France (EMBL) and to explore modern drug discovery approaches (GSK).

The ideal candidate will possess a PhD-level background in RNA biochemistry and an outstanding scientific track record, proven by high impact publications in peer-reviewed international journals. Experience in genomics or proteomics will be of advantage.

Applicants should send their CV summarizing qualifications and experience, including the names and addresses of two referees to:

Dr. Marco Marcia
mmarcia@embl.fr


[Post Date: April 10, 2017]

Title: Postdoc
Website: https://globaljobs.pfizer.com/pages/job-details.aspx

Description:
Post-doc Fellow position in membrane protein structural biology at Pfizer Inc. Job id #: 1051468. To apply, visit the following link:

https://www.linkedin.com/jobs/view/290461069?trk=jobs-home-jobsfe-redirect).

For people without Linkedin account, please apply using link below with Job id #1051468
https://globaljobs.pfizer.com/pages/job-details.aspx

Postdoctoral Fellow position at Pfizer focused on membrane protein structure-function studies

We are seeking a highly qualified and energetic PhD scientist to join us as a postdoctoral researcher focused on elucidating the three dimensional structures of membrane proteins that serve as important drug transporters. The incumbent will be trained in the state-of-the-art science of membrane protein structural biology, be exposed to the drug discovery and development process, and will learn the application of structure information in drug design. At our disposal, we have extensive in-house experience and resources supporting protein expression, purification, crystallization, structure determination of both soluble and membrane-bound proteins. Presently, Pfizer scientists have regular access to all the major X-ray synchrotron beam lines in the world, in house Cryo-EM facilities, and rich collection of small molecular ligands to enable protein stabilization and crystallization. Ideal candidates should have experience in protein expression, protein purification and crystallography, and preferably less than 4 years postdoctoral experience.

Pfizer Inc
Founded in 1849, Pfizer is the world's premier biopharmaceutical company. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support.

Job Focus
The postdoctoral fellow will join the Structural and Molecular Sciences group based in Groton CT, a multidisciplinary group that is well-established and recognized for its leadership in structural biology of both soluble and membrane proteins.

In this exciting and cross-disciplinary project, we aim to elucidate three dimensional structures of membrane proteins involved in drug transportation. Specifically, this research determines three dimensional structures of drug transporters and addresses the need of understanding structure-function relationship.

The incumbent is expected to work closely with fellow scientists across many other disciplines, deliver the results internally and externally via meeting presentations and publications.

Responsibilities
Optimize membrane protein constructs for functional expression and protein stability.
Purification of functional membrane proteins for structural determinations.
Protein crystallization and data collection. Sample preparation for Cryo-EM and data collection. Data analysis and structure determination. Structure analysis to understand structure-function relationship.
Interface with scientists across lines/discipline and show strong initiative in developing ideas to assist in the design of exploratory experiments.
Collect up-to-date information and keep abreast of the relevant literature, data acquisition and analysis, manuscript preparation, presentation of study results in oral and poster formats.

Qualifications
Ph.D. in structural biology with extensive knowledge in molecular biology, protein chemistry and wet lab protein structural biology skills.
Previous experience with protein construct design, expression and purification is required.
Previous experience with membrane protein is a plus.
Previous experience in structure determination is a plus.
Demonstrated track record of publishing in peer-reviewed scientific journals.
Excellent communication skills and ability to work independently are essential.


[Post Date: April 06, 2017]

Title: Postdoc Karolinska Institute

Description:
A two-year post-doctoral position is available at the Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institutet, Stockholm. The project deals primarily with over-expression, purification, crystallisation and structure determination of human membrane proteins involved in the generation of lipid mediators of inflammation. The successful candidate will join a multi-disciplinary research team and the position represents an opportunity for a postdoctoral scientist to develop their expertise as well as broaden their experience. The major interests of the lab are in membrane protein structure and function. We combine structural techniques such as macromolecular crystallography with biophysical, biochemical and computational methods to investigate the structural basis of catalysis. The lab has all necessary equipment and access to facilities needed for the project, including a core facility for protein science. We have periodic access to beamlines at ESRF (France), Diamond (UK), BESSY and DESY (Germany).

Qualifications:
The candidate should hold a PhD conferred within the previous two years (or expect conferral in the near future), be motivated to independently solve problems and a have a strong background in biochemistry or structural biology. Experience with protein expression, purification and biochemical characterisation is required. Prior experience in membrane protein biochemistry and computational skills such as a familiarity with the LINUX operating system will be added advantages.

The application should contain a single PDF document including:
• Letter of intention stating the scientific interests, technical skills, and previous experience of the candidate.
• CV including date and field of (expected) graduation and list of publications, with the contact information of at least two references.

This should be sent to joseph.brock@ki.se and Jesper.Haeggstrom@ki.se.

The deadline for application is the 28th of April, 2016.


[Post Date: April 05, 2017]

Title: Postdoc Sydney, Australia
Website: http://tinyurl.com/m7gybj3

Description:
We are seeking a recent PhD graduate for a postdoctoral position in structural biology. Applicants with experience in protein crystallography as well as mammalian cell culture, computational biology or RNA biology are particularly encouraged to apply. Please see link below for details.

https://www.seek.com.au/job/33144629?type=standout&tier=no_tier&pos=1&whereid=3000&userqueryid=cb3b40391f3562f29cc32f0db5fc087f-7329868&ref=beta


[Post Date: April 05, 2017]

Title: Two Postdoc Positions

Description:
Two post-doctoral positions are available in our laboratory to work on cutting edge projects related to GPCR biology (structural studies using X-ray and EM, discovering new signaling pathways, and generating synthetic tools to modulate receptor signaling).

We are looking for candidates with relevant experience (protein biochemistry, cell signaling, X-ray crystallography and Electron Microscopy).

Please refer to Nature Communications, 2016 Nov 9;7:13416; Cell, 2016 Aug 11;166(4):907-19; Nat Rev Mol Cell Biol, 2015 Feb;16(2):69-81; Cell, 2014 Dec 18;159(7):1712; Trends Biochem Sci, 2014 Dec;39(12):594-602; Nature, 2014 Aug 14;512(7513):218-22; Nature, 2013 May 2;497(7447):137-41 for a general overview of the research direction and experimental approaches.

These positions are supported by the Wellcome Trust DBT India Alliance, Department of Science & Technology (DST, India), and Department of Biotechnology (DBT, India).

Interested applicants are requested to send their CV and the name of three referees to arshukla@iitk.ac.in.


[Post Date: April 03, 2017]

Title: Postdoc

Description:
A postdoc position is available to study the mechanisms of regulation of the DNA replication/repair proteins using cross-disciplinary approaches in the Kelch Lab at UMass Medical School. Successful candidates will use biochemistry, computational biology, genetics, and structural biology to study the loading/unloading and function of the sliding clamp PCNA.

For more information on the Kelch Lab, please see our website:

http://labs.umassmed.edu/kelchlab/Lab_Website

Many resources are available for these studies, including a newly established high resolution cryoEM facility with Titan Krios and Talos Arctica EMs (both equipped with direct electron detectors) and a state-of-the-art x-ray diffraction facility adjacent to the Kelch lab. See http://www.umassmed.edu/research/cores/cryo-em-core-facility/ or http://www.umassmed.edu/research/cores/crystallography/ for more details. Numerous biochemical and biophysical instrumentation are available within the lab or Department of Biochemistry & Molecular Pharmacology. For career and professional development of the postdoc candidate, UMass Med has recently established the Center for Biomedical Career Development, a world-leader in innovative techniques for planning and enacting your career goals. See http://www.umassmed.edu/gsbs/career/ for more details.

Solid background in basic molecular biology, biochemistry and a demonstrated record of productivity is required. Candidates with strong quantitative skills and structural biology backgrounds are highly desired. Salary is based on NIH NRSA scale. Candidates are also encouraged to apply for independent fellowship to aid in their career/professional development.

Send a CV and a cover letter (~1 page) outlining your research experience and career goals.
Also, please names and contacts of three to four references to:
Brian.Kelch@umassmed.edu


[Post Date: April 03, 2017]

Title: Research Associate Novartis
Website: https://sjobs.brassring.com/tgwebhost/jobdetails.aspx?jobId=2477209&partnerid=13617&siteid=5260

Description:
Job ID 210144BR
Posting Title Scientist - Structural and Biophysical Chemistry
Division Novartis Institutes for BioMedical Research (NIBR)
Business Unit Global Discovery Chemistry
Country USA
Work Location Emeryville, CA
Company/Legal Entity USA Novartis Institutes for BioMedical Research, Inc., Cambridge, MA
Functional Area Research & Development
Job Type Full Time
Employment Type Regular

Job Description At Novartis Institutes for BioMedical Research (NIBR), the global research organization of Novartis, we are committed to discovering innovative medicines to cure disease and improve human health. By hiring the best academic, biotech, and pharmaceutical trained scientists, we have fostered an atmosphere for drug discovery where innovation is rewarded. It is ultimately the talent of the individual that determines our success, while our state-of-the-art technologies and resources enable these ideas to be realized.

NIBR has sites in Cambridge, Massachusetts; Emeryville, CA; Basel, Switzerland; San Diego, CA; and Shanghai, China. Our Emeryville location focuses on early drug discovery efforts for the Oncology and Infectious Disease Areas and offers a variety of positions in Biology, Chemistry, and functions such as Technology, Patents, Research Sciences and other areas that support our scientific resources.

About the Structural and Biophysical Chemistry Group:
The NIBR Emeryville Structural and Biophysical Chemistry group is responsible for generating the structures of macromolecular drug targets either in the apo form or in complex with lead compounds to help guide structure-based drug design. The group also provides biophysics and NMR solution studies support for hit finding campaigns in drug discovery projects.

Position Description
The ideal candidate will provide both crystallography and biophysics support to expedite various drug discovery and biologics projects at the NIBR Emeryville campus. The main responsibilities of this position include purification and biophysical characterization of proteins and protein-small molecule complexes (e.g. SPR, ITC, thermal shift, etc), crystallization screening, crystallographic data collection. The candidate should have the ability to work both independently and in a highly collaborative, cross-functional team.

EEO Statement The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status.

Minimum requirements Qualifications
Qualified candidates will have a B.S. or M.S. degree in chemistry, biochemistry, molecular biology, or a related field with at least 1-2 years of relevant work experience. Pharmaceutical and/or biotech industry experience is a plus. Experience with crystallization of novel proteins or protein complexes, crystallization robotics, imaging technologies and X-ray data collection is required. Hands-on experience with SPR, ITC, and thermal shift is also desirable. Experience in supporting fragment-based lead discovery is an asset. Candidates should have effective communication, presentation, and collaboration skills and be capable of handling multiple projects in a fast-paced, priority-driven environment.


[Post Date: April 03, 2017]

Title: Postdoc NE-CAT

Description:
Postdoctoral position in macromolecular crystallographic computing at NE-CAT, Cornell University

The Northeastern Collaborative Access Team (NE-CAT) at the Advanced Photon Source, Argonne National Laboratory is seeking applicants for a Postdoctoral Research Associate to work on the development, dissemination and support of RAPD, a software package developed at NE-CAT for real time analysis of macromolecular crystallographic (MX) data. The initial appointment is for two years with possibility of extension. The starting salary will be $70,000. The primary responsibilities will be to participate in the development of RAPD and to support the dissemination of RAPD to new sites including other MX beamlines and home laboratories. NE-CAT has developed RAPD, which provides indexing, strategy calculation, integration, data analysis, data set merging, and structure solution. We are currently in the process of extending the software and making it available to the MX community.

Knowledge, Skills, and Experience Requirements

Applicants should have a PhD in biochemistry or related field, with prior experience in the use of MX software for the analysis of synchrotron data. The applicant should have a strong interest in computer programming, and a working knowledge of programming languages such as Python, C, and JavaScript. Applicants must have strong interpersonal, organizational, and communication skills and be able to work well in a fast-paced environment. Applicants should submit a CV and arrange for three letters of reference of to be provided to Dr. Frank Murphy, fmurphy@anl.gov. Additional information about NE-CAT can be found at http://necat.chem.cornell.edu/.


[Post Date: April 03, 2017]

Title: Postdoc

Description:
UNIVERSITY OF OXFORD
DEPARTMENT OF BIOCHEMISTRY

Postdoctoral position – Towards deciphering mechanisms of transcriptional and post-transcriptional gene regulation in eukaryotic cells

We are looking for highly motivated postdoctoral scientist with an interest in gene regulation. The proposed projects will utilize state-of-the-art biochemistry and structural approaches combined with the functional genome-wide analysis to understand how transcription factors and chromatin modifiers regulate transcription of protein-coding and non-coding genes in yeast and mammalian cells. The structural study will be done as a part of existing productive collaboration with Jonathan Grimes laboratory at STRUBi (Oxford) (Wittmann et al., 2017 Nature Communication, in press). Candidates trained in protein purification, RNA analysis, and mammalian cell culture are encouraged to apply. Basic knowledge of bioinformatics is beneficial. Applicants should have or will shortly obtain a PhD and are expected to be highly motivated, have at least one first authorship publication, show excellent critical thinking and good communication skills and have the ability to work as part of a team.

Interested applicant should contact Dr Lidia Vasiljeva directly:

Dr. Lidia Vasiljeva: lidia.vasilieva@bioch.ox.ac.uk
Lab web site: http://www.bioch.ox.ac.uk/aspsite/index.asp?pageid=675
phone:(+44)-1865613352



[Post Date: March 23, 2017]

Title: Postdoc

Description:
A three-year postdoctoral position for a biochemist/structural biologist is available in the Department of Biochemistry, University of Cambridge, England. The Department has state-of-the-art equipment and facilities, including crystallization robots, NMR, cryo-EM, biophysics, metabolomics, and easy access to synchrotron beamlines and confocal microscopy. The postdoctoral position is available immediately with Dr Monique Gangloff following a New Investigator Research Grant award to study mosquito vector innate immunity.

We are looking for a highly motivated postdoctoral Fellow with a strong interest in Structural Biology, Signalling and Vector Biology. The project investigates the structure and function of mosquito immune receptors that have diverged and undergone gene duplication under the influence of selective pressure by pathogenic parasites and viruses, potentially acquiring new functions relating to host-pathogen homeostasis.

You will gain in-depth experience in Structural Biology by determining receptor-ligand complex structures using either X-ray crystallography or complementary techniques such as Small Angle X-ray Scattering (SAXS) and high-resolution cryo-EM. You will establish cell-based assays to verify predicted structure-function relationships. It is expected that you present your results at scientific conferences and write/publish scientific papers in high-quality, peer-reviewed journals.

Essential requirements:
• PhD in biochemistry, molecular and cellular biology, or related disciplines
• Strong background in construct design, molecular biology and protein purification
• Significant experience with biophysical and structural techniques
• Strong organizational and interpersonal skills
• A proven record of work published in reputable scientific journals.
Desirable requirements:
• Experience of protein expression methods using prokaryotic and eukaryotic in particular insect cell expression systems
• Proficiency in cell-based signaling assays to establish novel luciferase reporter assays in mosquito cell lines
• Knowledge in ligand fishing experiments using Mass Spectrometry
• Experience of working with Protein Crystallization, X-ray crystallography, SAXS, cryo-EM, Isothermal Titration Calorimetry and Surface Plasmon Resonance.

To apply online for this vacancy, please visit http://www.jobs.cam.ac.uk/job/13256/ then click on the 'Apply' button. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form.

The application should include a cover letter describing the candidate's research interests and motivation to apply, the CV and list of publications, and contact details of three referees.

Any enquires regarding the application process can be directed to Adriana Dote (personnel@bioc.cam.ac.uk).

Informal enquiries are welcome and can be made to Dr. Monique Gangloff (mg308@cam.ac.uk).

Please quote reference PH11763 on your application and in any correspondence about this vacancy.

The University values diversity and is committed to equality of opportunity.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.


[Post Date: March 23, 2017]
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